Benzodiazepines in the treatment of premenstrual and menopausal syndromes
Objective. To provide an update-based assessment of the relationship between genetic disorders of the receptor system and somatic and autonomic dysfunctions developing in the framework of premenstrual syndrome and premenstrual dysphoric disorder. The results of new trials of the efficacy of tofisopam (grandaxin) were also analyzed.Tikhomirov A.L., Sarsania S.I., Tuskaev K.S., Kazenashev V.V., Manukhin I.B.
Material and methods. Publications available in the international science citation databases were sought and analyzed.
Results. Tofisopam (grandaxin) is an anxiolytic drug but without muscle relaxant effects; and it can therefore be used in patients who continue to perform their professional duties. Tofisopam has the greatest autonomic stabilizing effect. Tofisopam has been shown to be particularly effective against autonomic disorders accompanying anxiety.
Conclusion. Tofisopam remains one of the best drugs in the safety and efficacy ratio today.
Keywords
premenstrual syndrome
premenstrual dysphoric disorder
depressive syndrome in pregnant women
postpartum depressions
climacteric and postovariectomic syndrome
daytime anxiolytic grandaxin
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Received 21.04.2017
Accepted 28.04.2017
About the Authors
Tikhomirov Alexander Leonidovich, Doctor of Medical Sciences, Professor of the Department of Obstetrics and Gynecology, Faculty of General Medicine, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia.127473, Russia, Moscow, Delegatskaya str. 20, bld. 1. Tel.: +74951782831. Email: pacificoff@mail.ru
Sarsania Svetlana Inorovna, doctor of the Federal Center for reproduction „Santa Maria”. 127051, Russia, Moscow, Tsvetnoy Boulevard str. 25, bld. 5. Tel.: +74959898981
Tuskaev Kazbek Serafilovich, doctor of the Federal Center for reproduction “Santa Maria”. 127051, Russia, Moscow, Tsvetnoy Boulevard str. 25, bld. 5. Tel.: +74959898981
Kazenashev Viktor Viktorovich, Candidate of Medical Sciences, Assistant of the Department of Obstetrics and Gynecology, Faculty of General Medicine,
A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia. 127473, Russia, Moscow, Delegatskaya str. 20, bld. 1. Tel.: +74951782831
Manukhin Igor Borisovich, MD, Professor, Head of the Department of Obstetrics and Gynecology, Faculty of General Medicine, A.I. Yevdokimov
Moscow State University of Medicine and Dentistry, Ministry of Health of Russia. 127473, Russia, Moscow, Delegatskaya str. 20, bld. 1. Tel.: +74991782831
For citations: Tikhomirov A.L., Sarsania S.I., Tuskaev K.S., Kazenashev V.V., Manukhin I.B. Benzodiazepines in the treatment of premenstrual and menopausal syndromes.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (5): 132-7. (in Russian)
http://dx.doi.org/10.18565/aig.2017.5.132-7
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