Optimization of the postembolization period in patients with uterine myoma
Objective. To investigate the efficacy of a venous protector in the complex relief of postembolization syndrome in patients with uterine myoma after uterine artery embolization (UAE).Yudina T.A., Manukhin I.B., Tikhomirov A.L.
Subjects and methods. 30 patients with uterine myoma and signs of venous/lymphatic insufficiency in the legs (Group 1) were given a venous protector (hesperidin 50 mg, diosmin 450 mg) as one tablet (500 mg) twice daily for one month on the first day following UAE. A control group (Group 2) consisted of 30 patients with post-UAE uterine myoma and without signs of venous/lymphatic insufficiency in the legs, who were not treated with a venous protector. The patients of the analyzed groups were matched for age, the location, size, and number of myomatous nodes. The time course of changes in the regression of myomatous nodes was assessed from ultrasonographic findings at 3 months after UAE. The degree of post-UAE pain syndrome was estimated using a 10-point scale.
Results. All the patients described the nature of pain syndrome in the first week after UAE equally; however, the 10-point scale intensity was much more pronounced in Group 2. Regression of myomatous nodes was more pronounced in Group 1 patients (36.5% versus 20.3%).
Conclusion. The findings may suggest that venous protective therapy can be used in patients undergoing UAE as a technique to optimize X-ray endovascular treatment and to reduce the severity of postembolization syndrome especially in patients with uterine myoma and venous/lymphatic insufficiency in the lower limbs.
Keywords
uterine artery embolization
uterine myoma
postembolization syndrome
venous/lymphatic insufficiency
venous protectors
Supplementary Materials
References
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Received 08.09.2017
Accepted 22.09.2017
About the Authors
Yudina Tatiana Alexandrovna, gynecologist of the multi-profile medical holding SM-Clinic. Russia, Moscow, Klary Tsetkinoi str. 33/28. Tel.: +74957774849Manukhin Igor Borisovich, MD, professor, head of the Department of Obstetrics and Gynecology, Medical Faculty, A.I. Evdokimov Moscow State University of Medicine and Dentistry. 127473, Russia, Moscow, Delegatskaya str. 20, bld. 1. Tel.: +74991782831
Tikhomirov Alexander Leonidovich, MD, Professor of the Department of Obstetrics and Gynecology, Medical Faculty, A.I. Evdokimov Moscow State University of Medicine and Dentistry. 127473, Russia, Moscow, Delegatskaya str. 20, bld. 1. Tel.: +74991782831. E-mail: pacificoff@mail.ru
For citations: Yudina T.A., Manukhin I.B., Tikhomirov A.L. Optimization of the postembolization period in patients with uterine myoma. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (12): 110-4. (in Russian)
https://dx.doi.org/10.18565/aig.2017.12.110-114
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