Optimization of endometrial preparation prior to assisted reproductive technology programs for HIV-infected women with tuboperitoneal factor infertility
Objective. To assess the possibility of enhancing the efficiency of assisted reproductive technologies (ART) in HIV-infected patients with infertility after therapeutic and diagnostic hysteroscopy (TDH).Medvedeva V.V., Malygina G.B.
Subjects and methods. A prospective study was conducted in 121 HIV-infected women with infertility in preparation for ART. Of them, 63 patients underwent TDH (a study group) and 58 patients did not (a control group); randomization was performed by an envelope method. The investigation methods included histology and ultrasonography (USG).
Results. Endometrial pathology was detected in 79.5% of the study group and in 51% of the control group where only USG was carried out (p < 0.05). After TDH conducted before IVF, the pregnancy rate was higher (40.7 versus 14.2%; p < 0.05); the frequency of miscarriage with a small duration of gestation was lower (14.8 versus 50%; p < 0.05).
Conclusion. TDH in HIV-infected patients with infertility enhances the efficiency of IVF and reduces the risk of miscarriage.
Keywords
infertility
assisted reproductive technologies
human immunodeficiency virus
therapeutic and diagnostic hysteroscopy
histological examination
Supplementary Materials
- Table 1. Peculiarities of anamnesis in HIV-infected patients with infertility who applied for carrying out ART
- Table 2. The results of the ultrasound study patients of the main and control groups
- Figure 1. The structure of the pathology of the endometrium in infertile patients with HIV according to histological findings (%)
- Figure 2. Reproductive outcomes of assisted reproduction in women of the main and control groups (%) ( p<0.05)
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Received 15.05.2017
Accepted 23.06.2017
About the Authors
Medvedeva Valentina Vladimirovna, MD, aspirant, Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia; Family Medicine Center.620043, Russia, Yekaterinburg, N. Vasilieva str. 1/3. Е-mail: Medvedeva-V-V@mail.ru
Malgina Galina Borisovna, doctor of medical Sciences, Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia.
620028, Russia, Yekaterinburg, Repina str. 1. Tel.: +73433714293. E-mail : galinamalgina@mail.ru. ORCID ID 0000-0002-5500-6296
For citations: Medvedeva V.V., Malygina G.B. Optimization of endometrial preparation prior to assisted reproductive technology programs for HIV-infected women with tuboperitoneal factor infertility. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (2): 96-101. (in Russian)
https://dx.doi.org/10.18565/aig.2018.2.96-101
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