Optimization of treatment for vulvovaginitis in patients with persistent herpesvirus infection
Objective. To optimize treatment and intimate hygiene for mixed and Candida vulvovaginitis in patients with persistent herpesvirus infection.Kononova I.N., Dobrokhotova Yu.E., Kareva E.N., Shmakova N.A., Kotelnikova A.E., Graban I.V., Ovchinnikova L.E.
Materials and methods. Eighty-three patients with mixed vulvovaginitis and 81 patients with vulvovaginal candidiasis that had developed in the presence of persistent herpesvirus infections were examined and treated. In mixed vulvovaginitis, standard local antibacterial therapy + Panavir as one suppository once daily was prescribed for 10 days. In Candida vulvovaginitis, antimycotics + Panavir as one suppository once daily was used for 10 days. At the second stage, both groups underwent comparative characterization of the feminine intimate sprays Panavir intima and Panavir Intima Normaflor used once daily for 14 days, followed by their application once every 3 days for another 2 weeks.
Results. Including the antiviral drug Panavir and the spray Panavir Intimate Normaflor along with antibacterial drugs in the therapy of mixed vulvovaginitis showed a 6.4-fold reduction in disease recurrence. Incorporating the antiviral drug Panavir as suppositories along with antimycotics, as well as the spray Panavir Intima at the second stage displayed a 9.1-fold decrease in the recurring process.
Conclusion. To optimize therapy for vulvovaginitis in the presence of herpesvirus infections, it is advisable to take the antiviral drug Panavir with a subsequent recommendation to use the feminine intimate sprays Panavir Intima Normaflor and Panavir Intima for mixed vulvovaginitis and candida vulvovaginitis, respectively.
Keywords
vulvovaginitis
herpesvirus infections
Panavir
Panavir Intim
Panavir Intim Normaflor
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Received 16.06.2021
Accepted 21.06.2021
About the Authors
Irina N. Kononova, Dr. Med. Sci., Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia. E-mail: irkonmed@mail.ru. ORCID: 0000-0003-3483-9464. 117997, Russia, Moscow, Ostrovityanova str., 1.Yuliya E. Dobrokhotova, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Faculty of Medicine, N.I. Pirogov Russian National Research
Medical University, Ministry of Health of Russia. E-mail: pr.dobrohotova@mail.ru. ORCID: 0000-0003-2786-6181. 117997, Russia, Moscow, Ostrovityanova str., 1.
Elena N. Kareva, D. Med. Sci., Professor of the P.V. Sergeyev Department of Molecular Pharmacology and Radiobiology, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; Professor, Department of Pharmacology, Faculty of Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University). E-mail: elenakareva@mail.ru. 117997, Russia, Moscow, Ostrovityanova str., 1.
Nadezhda A. Shmakova, obstetrician-gynecologist of the 1st category, MC «Angioline», Yekaterinburg. Тел.: +7(902)277-37-12. E-mail: naschmakova@yandex.ru.
ORCID: 0000-0002-4797-3876. 620027, Russia, Россия, Yekaterinburg, Eremina str., 3.
Alina E. Kotelnikova, obstetrician-gynecologist of the highest category, Head of Women’s Health Clinic, Berezovsky Central City Hospital, Berezovsky, Sverdlovsk region.
E-mail: kossnya23@gmail.com. 623701, Russia, Sverdlovsk region, Berezovsky, Shilovskaya str., 28.
Irina V. Graban, obstetrician-gynecologist of the highest category, MC "Edelweiss", Yekaterinburg. E-mail: а9229@yandex.ru.
620142, Russia, Yekaterinburg, March 8 str., 127.
Liudmila E. Ovchinnikova, obstetrician-gynecologist of the 1st category, Central City Clinical Hospital No. 6, Women’s Health Clinic No. 1, Yekaterinburg.
E-mail: e180oo@yandex.ru. 620144, Russia, Yekaterinburg, March 8 str., 126.
For citation: Kononova I.N., Dobrokhotova Yu.E., Kareva E.N., Shmakova N.A., Kotelnikova A.E., Graban I.V., Ovchinnikova L.E. Optimization of treatment for vulvovaginitis in patients with persistent herpesvirus infection.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 6: 146-154 (in Russian)
https://dx.doi.org/10.18565/aig.2021.6.146-154
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