Evaluation of the medicinal properties of a contraceptive containing ethinylestradiol and chlormadinone acetate
Objective. To evaluate the medicinal properties of an agent containing ethinylestradiol (EE) and chlormadinone acetate (CMA) in contraceptive-needing patients within the framework of the pharmacological epidemiological observational project.Podzolkova N.M., Koloda Yu.A., Korennaya V.V., Aksenenko V.A., Bakirova N.E., Vorontsova A.V., Enkova E.V., Karakhalis L.Yu., Katkova N.Yu., Minkina G.N., Misharina E.V., Olina A.A., Sotnikova L.S., Spiridonova N.V., Tkachenko L.V., Khachaturyan A.R.
Subjects and methods. The investigation enrolled 161 contraception-needing patients. All the patients had no contraindications to combined oral contraceptives (COCs) and conditions in which COCs should be used with caution. All the women took EE in combination with CMA in a 21/7 cyclic regimen for contraception. To evaluate the medicinal properties of the agent, the investigators studied its effects on the nature of menstruation and related symptoms (tenderness, frequency of breast pain prior to menstruation, abundant discharge), and the skin (acne frequency and severity, skin oiliness).
Results. During the investigation, there were pronounced changes associated with a decrease in complaints related to painful menstruation, their abundance, premenstrual breast pain; acne severity and higher skin fat content reduced.
Conclusion. The findings may consider COC with EE/CMA as an agent having an anti-androgenic effect that can reduce the frequency and degree of manifestation of acne, have a positive effect on the nature of menstruation.
Keywords
ethinylestradiol
chlormadinone acetate
medicinal properties
painful menstruation
Supplementary Materials
- Table 1. Change character menses at group I and II on background admission COOK fromethinyl estradiol ohm / chloromadinone acetate
- Table 2 . Numeric meanings dermatological index
- Fig . 1. The number of patients I and II groups with no complaints at 3 and 6 months. after application of COC with EE / HMA
- Fig . 2. A - degree of acne in the opinion of patients from II groups before and during EE / CMA intake; B - degree of acne in the opinion of patients from I group before and during the reception ofEE / HMA
- Fig . 3. A - number of patients with increased skin fatigue from I groups before and during EE / CMA intake; B - number of patients with increased fat content of skin from II group before and during the reception of EE / HMA
- Fig . 4 . Dynamics of the degree of acne A. In the group of practically healthy women ( I group) on the background of taking COC with XMA. B. Patients in Group II before and during the administration of COC with XMA.
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Received 08.12.2017
Accepted 22.12.2017
About the Authors
Podzolkova Nataliya Mikhaylovna, Doctor of Medicine, Professor, Department of Obstetrics and Gynecology, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia. 125993, Russia, Moscow, Barrikadnaya str. 2/1. Tel.: +74992522104. E-mail: podzolkova@gmail.comKoloda Yuliya Alekseevna, PhD, Assistant Professor, Department of Obstetrics and Gynecology, Russian Medical Academy of Continuing Professional Education,
Ministry of Health of Russia. 125993, Russia, Moscow, Barrikadnaya str. 2/1. Tel.: +74992522104. E-mail: julkol@yandex.ru
Korennaya Vera Vyacheslavovna, PhD, Assistant Professor, Department of Obstetrics and Gynecology, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia. 125993, Russia, Moscow, Barrikadnaya str. 2/1. Tel.: +74992522104. E-mail: drkorennaya@mail.ru
Aksenenko Viktor Alekseevich, chief obstetrician-gynecologist, Ministry of health of the Stavropol territory, Doctor of Medicine, Professor, Head of the department
of Obstetrics and Gynecology, Stavropol State Medical University. 355000, Russia, Stavropol, Mira str. 310. Tel.: +78652716536. E-mail: aksenenko_@mail.ru
Bakirova Nailya Edgarovna, Candidate of Medical Sciences, Senior Lecturer of Department of Surgery, Kazan (Volga) Federal University;
Head of the Department of gynecology, KORL LLC. 420059, Russia, Kazan, Daurskaya str. 12. Tel.: +78432778837. E-mail: nailyabak@yandex.ru
Vorontsova Anna Valeryevna, Candidate of Medicine, Associate Professor of the Department of Obstetrics and Gynecology, Ural State Medical University,
Ministry of Health of Russia. 620215, Russia, Yekaterinburg, Repina str. 1. Tel.: +73432979861. E-mail: a_valerevna@mail.ru
Enkova Elena Vladimirovna, Doctor of Medical Science, Professor of the Surgery, Obstetrics and Gynecology Department of the Institute of Additional Postgraduate Education, N.N. Burdenko Voronezh State Medical University. 394024, Russia, Voronezh, Studencheskaya str. 10. Tel.: +74732644418. E-mail: enkova@bk.ru
Karakhalis L.Y., MD, PhD, professor, the Department of Obstetrics, Gynecology, and Perinatology, Faculty of Postgraduate Education, Kuban State Medical University, Ministry of Health of Russia. 350063, Russia, Krasnodar, Sedina str., 4. Tel.: +78612220543. E-mail: lomela@mail.ru
Katkova Nadezhda Yuryevna, Department of Obstetrics and Gynecology, Postgraduate Education Faculty, Nizhny Novgorod State Medical Academy.
603005, Russia, Nizhny Novgorod, Minin and Pozharsky sq. 10/1. Tel.: +78314657575. E-mail: rector@gma.nnov.ru
Minkina Galina Nikolaevna, Doctor of Medicine, Professor of Department of Obstetrics and Gynecology, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia. 127473, Russia, Moscow, Delegatskaya str. 20/1. Tel.: +74991795971. E-mail: minkinagn@mail.ru
Misharina Elena V., PhD, senior researcher at the Department of Endocrinology, D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology.
199034, Russia, Saint Petersburg, Mendeleevskaya line 3. Tel.: +78123289820. E-mail: mishellena@gmail.com
Olina Anna Alexandrovna, Doctor of Medicine, Professor of Department of obstetrics and gynecology, Academician E.A. Vagner Perm State Medical University,
Ministry of Health of Russia. 614990, Russia, Perm, Petropavlovskaya str. 26. Tel.: +73422172020. E-mail: olina29@mail.ru
Sotnikova Larisa Stepanovna, Doctor of Medicine, Professor, Siberian State Medical University, Ministry of Health of Russia.
634050, Russia, Tomsk, Moscovsky trakt 2. Tel.: +73822468700. E-mail: profmed.tomsk@gmail.com
Spiridonova Natalia V., Doctor of Medicine, Professor, the Head of the Department of Obstetrics and Gynecology Obstetrics, Institution of Postgraduate Studies,
Samara State Medical University Samara. 443099, Russia, Samara, Chapayevskaya str. 8. E-mail: nvspiridonova@mail.ru
Tkachenko Ludmila Vladimirovna, Doctor of Medicine, Professor, Head of Department of obstetrics and gynecology, Faculty of advanced training of doctors,
Volgograd State Medical University. 400131, Russia, Volgograd, Pavshikh Bortsov Sq. 1. Tel.: +78442385005. E-mail: Tkachenko.fuv@mail.ru
Khachaturian Armine Robertovna, Associate Professor of the Department of Obstetrics, Gynecology and Reproductology, Saint Petersburg State University.
199034, Russia, St-Petersburg, University embankment, 7-9. Tel.: +78123289820. E-mail: armine2709@mail.ru
For citations: Podzolkova N.M., Koloda Yu.A., Korennaya V.V.,
Aksenenko V.A., Bakirova N.E., Vorontsova A.V., Enkova E.V., Karakhalis L.Yu.,
Katkova N.Yu., Minkina G.N., Misharina E.V., Olina A.A., Sotnikova L.S.,
Spiridonova N.V., Tkachenko L.V., Khachaturyan A.R.
Evaluation of the medicinal properties of a contraceptive containing
ethinylestradiol and chlormadinone acetate.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (3): 109-15. (in Russian)
https://dx.doi.org/10.18565/aig.2018.3.109-115
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