Molecular markers for endometrial receptivity in assisted reproductive technology programs

Gokhberg Ya.A., Timofeeva A.V., Kalinina E.A.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Despite the increasing effectiveness of assisted reproductive technology (ART) programs, the frequency of successful embryo implantations remains low. The lack of implantation may be associated with impaired endometrial receptivity during the implantation window. To determine the receptivity of the endometrium, various diagnostic methods, such as histological analysis, electron microscopy, immunohistochemical examination, and molecular genetic analysis, have been developed and used; however, many of them depend on contributing factors and are of ow functional significance in solving this problem. The search for an ideal marker is now ongoing to determine the best moment for embryo transfer into the uterine cavity for an in vitro fertilization (IVF) cycle. The use of omix technologies to study the embryo culture medium could predict not only the quality, but also implantation potential of the embryo itself, as well as optimize the selection of embryos for transfer to the uterine cavity. However, to enhance the effectiveness of ART programs, it is advisable not only to study the embryonic profile, but also to assess endometrial receptivity.
Conclusion: In this connection, analyzing the literature sources has shown that the study of the small non-coding RNA (sncRNA) in the endometrial samples is a promising and relevant analysis that will be able to personalize the approach to implementing ART programs.

Keywords

assisted reproductive technologies
pregnancy
embryo implantation
embryo culture medium
endometrial receptivity
infertility
small non-coding RNA (sncRNA)
miRNA
piRNA
omix technologies
ERA test

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Received 28.06.2021

Accepted 12.07.2021

About the Authors

Yael A. Gokhberg, postgraduate student at the B.V. Leonov Department of Assisted Technologies for the Treatment of Infertility, V.I. Kulakov NMRC for OG&P,
Ministry of Health of Russia, dr.yaelgokhberg@gmail.com, 4 Oparin str., 117997, Moscow, Russia.
Angelika V. Timofeeva, M.D., Ph.D., Head of Laboratory of applied transcriptomics, V.I. Kulakov NMRC OG&P, Ministry of Health of the Russian Federation,
avtimofeeva28@gmail.com, 4 Oparin str., 117997, Moscow, Russia.
Elena A. Kalinina, Dr. Med. Sci., Professor, Head of the B.V. Leonov Department of Assisted Technologies for the Treatment of Infertility, V.I. Kulakov NMRC for OG&P, Ministry of Health of the Russian Federation, e_kalinina@oparina4.ru, 4 Oparin str., 117997, Moscow, Russia.

Authors’ contributions: Gokhberg Ya.A. – literature data collection and analysis; processing of the source material and writing the article; Timofeeva A.V., Kalinina E.A. – editing the manuscript of the article and approval of the publication.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation has been conducted without additional funding from the third parties.
For citation: Gokhberg Ya.A., Timofeeva A.V., Kalinina E.A. Molecular markers for endometrial receptivity in assisted reproductive technology programs.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 11: 56-62 (in Russian)
https://dx.doi.org/10.18565/aig.2021.11.56-62

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