Drug treatment for endometriosis-related pain

Dubrovina S.O., Berlim Yu.D.

Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia
Endometriosis remains one of the most pressing problems in gynecology. Despite a large number of studies, there is no ideal pathogenetically substantiated therapy for endometriosis today. Hormone therapy remains a mainstay of medical treatment for the disease. Despite that there are no indications for the treatment of endometriosis and pelvic pain, combined oral contraceptives (COCs) are commonly prescribed as before. However, due to data on the progression of the disease to a more invasive type in women who have taken COCs for primary dysmenorrhea, foreign and Russian guidelines are increasingly giving preference to gestagens in the treatment of endometriosis with pain syndrome, and, in case of their resistance, gonadotropin-releasing hormone agonists are chosen. Among the gestagens, dyirogesterone occupies a special place due to its high selectivity and good safety profile, which makes it currently the drug of choice in the treatment of endometriosis.


combined oral contraceptives
gonadotropin-releasing hormone antagonists


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Received 15.02.2019

Accepted 22.02.2019

About the Authors

Dubrovina, Svetlana O., MD, professor, chief researcher, Rostov Scientific Research Institute of Obstetrics and Pediatrics, Rostov State Medical University.
344022, Russia, Rostov-on-Don, per. Nakhichevansky str. 29. Tel.: +79185585113. Е-mail: s.dubrovina@gmail.com
Berlim, Yuliya D., PhD, head of the advisory outpatient department, Rostov State Medical University.
344022, Russia, Rostov-on-Don, per. Nakhichevansky str. 29. Tel.: +79185002356. Е-mail: juliaberlim@yandex.ru.

For citations: Dubrovina S.O., Berlim Yu.D. Drug treatment for endometriosis-related pain. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (2): 34-40. (in Russian)

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