Correction of mastalgia and hyperprolactinaemia in women in perimenopause
Objective. To evaluate the efficacy of mastodynon in eliminating complaints of mastalgia and in reducing hyperprolactinemia.Lazareva G.A.
Subjects and methods. After informed consent was obtained, 66 perimenopausal patients with complaints of breast pain and engorgement were divided into two groups: 1) 45 patients took mastodynon; 2) 21 patients received diclofenac rectal suppositories. During a follow-up, the patients kept diaries (indicating the severity of mastalgia, possible side effects of therapy). All the patients underwent clinical examination, breast ultrasound and mammography. Serum prolactin levels were measured before and 3 and 6 months after treatment.
Resu1ts. Mastodynon treatment showed a positive clinical effect that was characterized by a reduction in pain syndrome and normalization of the hormone to the average value. Prolactin levels in the control group remained unchanged during the study.
Conclusion. The data of the investigation have confirmed the possibility of effectively using mastodynon in perimenopausal women. The drug is safe and well tolerated.
Keywords
mastalgia
prolactin
mastopathy
mastodynon
References
1. Jatoi Ismail, Kaufmann M. eds. Management of breast diseases. New York: Springer; 2009. 671р.
2. Ognerubov N.A., Kushlinskiy N.E., Tkacheva I.A. Clinical and endocrinological studies in mastopathy and breast cancer. Voronezh: Istoki; 1998. 176p. (in Russian)
3. Smetnik V.P., Tumilovich L.G. Non-operative gynecology. Moscow: MIA; 2001. (in Russian)
4. Semiglazov V.F., Vesnin A.G., Moiseenko V.M. Minimal breast cancer (prevention, detection, treatment). St. Petersburg: Hippocrates; 2009. 240p. (in Russian)
5. Letyagin V.P. Mastopathy. Russian medical journal. 2000; 8(11): 468-73. (in Russian)
Received 07.02.2017
Accepted 17.02.2017
About the Authors
Lazareva Galina Anatolyevna, MD, professor of the Obstetrics and Gynecology Department of the Kursk State Medical University,Ministry of Health of Russia; doctor of the medical center „Zhivitsa”. 305004, Russia, Kursk, Lysaya Gora str. 11. Tel.: +79103104503. E-mail: galinal2007@yandex.ru
For citations: Lazareva G.A. Correction of mastalgia and hyperprolactinemia in perimenopausal women. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (4): 144-8. (in Russian)
http://dx.doi.org/10.18565/aig.2017.4.144-8
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