Comorbid conditions in genital prolapse
Objective. To analyze genital prolapse in patients with comorbidity.Musin I.I., Yashchuk A.G.
Subjects and methods. This paper evaluates extragenital disease and previous surgical interventions in women operated on. A total of 718 patients with POP-Q grade II–IV were operated on; 62 patients underwent bone mineral density (BMD) estimation. Statistical processing was performed using SPSS17 Statistics 17.0 and StatSoft STATISTICA 10.0.
Results. The anamnesis contained predominantly cardiovascular disorders: grade I hypertensive disease (HD) in 30 (4.2%) women, grade II HD in 194 (27.0%) patients, grade III HD in 40 (5.6%), lower extremity varices in 40 (8.4%), and diabetes mellitus (DM) in 38 (5.3%). An ROC analysis could provide evidence for the hypothesis that HD had an impact on the increase in the incidence of genital prolapse (AUC = 0.643±0.03; p = 0.012).
Conclusion. The age-related combination of HD, DM, lower BMD, and POP-Q grade II–IV is an urgent problem. Additional studies of this group of diseases are required to determine the factors that influence the deterioration of the course of these interrelated conditions, to define criteria of inclusion into risk groups, and to improve methods for diagnosis and treatment of this comorbidity.
Keywords
pelvic organ prolapse
pelvic floor
quality of life
surgery
References
- Kerkhof M.H., Hendriks L., Brölmann H.A.M. Changes in connective tissue in patients with pelvic organ prolapse – a review of the current literature. Int. Urogynecol. J. Pelvic Floor Dysfunct. 2009; 20(4): 461-74. https://dx.doi.org/10.1007/s00192-008-0737-1.
- Cooper J., Annappa M., Dracocardos D., Cooper W., Muller S., Mallen C. Prevalence of genital prolapse symptoms in primary care: a cross-sectional survey. Int. Urogynecol. J. 2014; 26(4): 505-10. https://dx.doi.org/10.1007/s00192-014-2556-x.
- Swift S., Woodman P., O'Boyle A., Kahn M., Valley M., Bland D. et al. Pelvic organ support study (POSST): the distribution, clinical definition, and epidemiologic condition of pelvic organ support defects. Am. J. Obstet. Gynecol. 2005; 192(3): 795-806. https://dx.doi.org/10.1016/j.ajog.2004.10.602.
- Jackson S., James M., Abrams P. The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence. BJOG. 2002; 109(3): 339-44. https://dx.doi.org/10.1111/j.1471-0528.2002.01052.x.
- Cao Q., Chen Y.S., Ding J.X., Hu C.D., Feng W.W., Hu W.G., Hua K.Q. Long-term treatment outcomes of transvaginal mesh surgery versus anterior-posterior colporrhaphy for pelvic organ prolapse. Aust. N. Z. J. Obstet. Gynaecol. 2013; 53(1): 79-85. https://dx.doi.org/10.1111/ajo.12040.
- Whitcomb E.L., Rortveit G., Brown J.S., Creasman J.M., Thom D.H., Van Den Eeden S.K., Subak L.L. Racial differences in pelvic organ prolapse. Obstet. Gynecol. 2009; 114(6): 1271-7. https://dx.doi.org/10.1097/AOG.0b013e3181bf9cc8.
- World Health Organization. Use of glycated haemoglobin (HbA1c) in the diagnosis of diabetes mellitus: abbreviated report of a WHO consultation. Geneva: WHO; 2011.
- Bohoussou E., Adjoussou S.A., Letouzey V., Fatton B., de Tayrac R. Should we perform intra-operative endometrial biopsy during pelvic reconstructive surgery with uterine preservation? J. Gynecol. Obstet. Biol. Reprod. (Paris). 2014; 43: 40-5. https://dx.doi.org/10.1016/j.jgyn.2013.10.011.
- Isik H., Aynioglu O., Sahbaz A., Selimoglu R., Timur H., Harma M. Are hypertension and diabetes mellitus risk factors for pelvic organ prolapse? Eur. J. Obstet. Gynecol. Reprod. Biol. 2016; 197: 59-62. https://dx.doi.org/10.1016/j.ejogrb.2015.11.035.
- Weli H., Cooper J., Yang Y. New insight into glycation levels and pelvic organ prolapse - a combination of clinical and biochemical studies. Eur. J. Obstet. Gynecol. Reprod. Biol. 2018; 231: 129-35. https://dx.doi.org/10.1016/j.ejogrb.2018.10.010.
- Kanis J., Borgstrom F., Zethraeus N., Johnell O., Oden A., Jönsson B. Intervention thres holds for osteoporosis in the UK. Bone. 2005; 36(1): 22-32. https://dx.doi.org/10.1016/j.bone.2004.08.018.
- McLennan M.T., Harris J.K., Kariuki B., Meyer S. Family history as a risk factor for pelvic organ prolapse. Int. Urogynecol. J. Pelvic Floor Dysfunct. 2008; 19(8): 1063-9. https://dx.doi.org/10.1007/s00192-008-0591-1.
Received 27.04.2020
Accepted 03.07.2020
About the Authors
Il’nur I. Musin, Cand. Med. Sci., Associate Professor of the Department of Obstetrics and Gynecology with course ISPE of Bashkir State Medical University of the Ministry of Health of the Russian Federation. Tеl.: +7(917)467-10-64. E-mail: ilnur-musin@yandex.ru. 450008, Russia, Bashkortostan, Ufa, Lenin str., 3.Alfiya G. Yashchuk, Doc. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology with course ISPE of Bashkir State Medical University of the Ministry of Health of the Russian Federation. Tеl.: +7(3472)64-96-50. E-mail: alfiya_galimovna@mail.ru. 450008, Russia, Bashkortostan, Ufa, Lenin str., 3.
For citation: Musin I.I., Yashchuk A.G. Comorbid conditions in genital prolapse.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 8: 154-158 (in Russian).
https://dx.doi.org/10.18565/aig.2020.8.154-158
Similar Articles
