Combined oral contraceptives: Benefits and risks

Dubrovina S.O.

Research Institute of Obstetrics and Pediatrics, Rostov State Medical University, Ministry of Health of Russia, Rostov on Don 344012, Mechnikova str. 43, Russia
Objective. To carry out a systematic analysis of the data available in the current literature on the benefits and possible risks of combined oral contraceptive (COC) use.
Material and methods. The review included the data of foreign articles published in the past 10 years and found in PubMed on this topic.
Results. This paper disproves the myths that exist about COCs and sets out their benefits and the rules of switching from COCs to hormone replacement therapy. It presents data on the effect of COCs on cancers at different sites. The possible risks of COCs are assessed.
Conclusion. COCs are not only a reliable means of contraception, but also have a number of significant benefits, including for reducing the risk of cancers at different sites. To avoid possible side effects, all possible benefits and risks of COCs should be weighed before their prescription.




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Received 16.06.2017

Accepted 23.06.2017

About the Authors

Dubrovina Svetlana, professor, PhD, MD, the main scientistic researcher of Scientific Research Institute of Obstetrics and Pediatrics of Rostov State Medical University. 344012, Russia, Rostov on Don, Mechnikova str. 43. Tel.: +78632504200. E-mail:

For citations: Dubrovina S.O. Combined oral contraceptives: Benefits and risks. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (9): 132-7. (in Russian)

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