Cerebral hemodynamic changes in different forms of hypertension in the third trimester of pregnancy

Khramchenko N.V., Voevodin S.M., Andronova N.V.

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia
Objective. To investigate cerebral hemodynamics in pregnant women with hypertension.
Subjects and methods. Cerebral hemodynamic parameters in the middle cerebral artery (MCA) and Rosenthal veins were investigated in 100 women with manifestations of hypertension occurring during pregnancy: in those with severe preeclampsia (PE) (n = 20), moderate PE (n = 35), and gestational hypertension (GH) (n = 45), or physiological pregnancy (n = 74). Regression analysis revealed the critical values of MCA pulsatility index (PI), which corresponded to severe PE.
Results. The values of MCA мaximum blood flow velocity were higher in all the groups of pregnant women with hypertension than those in the control group: 170.5±19.4 cm/sec in the pregnant women with GH,
140.8±19.4 cm/sec in those with severe PE, and 121.4± 23.4 cm/sec in those with moderate PE.
The distinguishing characteristic of both moderate and severe PE from GH was the values of MCA PI: lower PI values in PE (0.68±0.09 and 0.61±0.07, respectively) and higher PI values in GH (0.98±0.14).
Conclusion. Transcranial Doppler ultrasonography allows identification of patients with critical cerebrovascular events.

Keywords

preeclampsia
gestational hypertension
cerebral arteries
Rosenthal vein
Doppler study
pregnancy

References

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Received 26.08.2016

Accepted 02.09.2016

About the Authors

Natalia V. Khramchenko, head of the Department of Echography and Prenatal Diagnostics, Research Center of Obstetrics, Gynecology, and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79104402274. E-mail: n_khramchenko@oparina4.ru
Sergey M. Voevodin, Head of the Visual Diagnostics Department, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: v_voevodin@oparina4.ru
Natalia V. Andronova, a geneticist, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: andronowa@mail.ru

For citations: Khramchenko N.V., Voevodin S.M., Andronova N.V. Cerebral hemodynamic changes in different forms of hypertension in the third trimester of pregnancy. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (4): 81-6. (in Russian)
http://dx.doi.org/10.18565/aig.2017.4.81-6

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