Use of menopausal hormone therapy in the correction of cognitive impairment in menopausal women
Objective. To assess changes in cognitive function and quality-of-life indicators in menopausal women receiving different types of menopausal hormone therapy (MHT).Gasparyan S.A., Drosova L.D., Karpov S.M., Khripunova A.A.
Subjects and methods. Eighty postmenopausal women with neurovegetative and psychoemotional symptoms were divided into 4 groups: 1) 17-ß estradiol 1 mg, drospirenone 2 mg; 2) transdermal 17-ß estradiol 0.06% gel, oral micronized progesterone 200 mg; 3) monotherapy with transdermal 17-ß estradiol 0.06% gel; 4) no MHT. The Kupperman index, NGF, MoCA test, SF-36 scale, and Beck Depression Inventory were applied to examined the women’s status.
Results. NGF levels were significantly increased and the neurovegetative, psychoemotional status improved in Group 1 versus Group 2. Changes were absent in Group 3; cognitive impairment progressed in Group 4.
Conclusion. The systemic administration of 17-ß estradiol 1 mg, drospirenone 2 mg versus transdermal 17-ß estradiol 0.06% gel, oral micronized progesterone 200 mg or estrogen monotherapy is effective in restoring cognitive functions and quality of life in early postmenopause.
Keywords
combined hormone therapy
anjeliq
cognitive impairment
menopause
nerve growth factor
quality of life
References
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Received 30.10.2018
Accepted 07.12.2018
About the Authors
Gasparyan, Susanna A., MD, professor, Department of Obstetrics and Gynecology, Stavropol State Medical University.355017, Russia, Stavropol, Mira str. 310. E-mail: Prof-Gasp55@yandex.ru
Drosova, Larisa D., postgraduate student of the Department of Obstetrics and Gynecology, Faculty of Postgraduate and Further Education, Stavropol State Medical University. 355017, Russia, Stavropol, Mira str. 310. Tel.: +79280130600. E-mail: azrunc@bk.ru
Karpov, Sergey M., MD, Professor head of the Department of neurology, neurosurgery and medical genetics Stavropol State Medical University.
355017, Russia, Stavropol, Mira str. 310. E-mail: karpov25@rambler.ru
Khripunova, Alesya A., Ph.D., Associate Professor, Department of Public Health, Public Health Service and Medical Informatics, Stavropol State Medical University.
355017, Russia, Stavropol, Mira str. 310. E-mail: fktcz2007@yandex.ru
For citations: Gasparyan S.A., Drosova L.D., Karpov S.M., Khripunova A.A. Use of menopausal hormone therapy in the correction of cognitive impairment in menopausal women. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (12): 157-62. (in Russian)
http://dx.doi.org/10.18565/aig.2018.12.157-162
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