Innovative laser technologies in the diagnosis and treatment of the endometrium of concern in reproductive medicine

Zuev V.M., Kalinina E.A., Kukushkin V.I., Dzhibladze T.A., Zharov E.V., Montanino M.O.

1 ART-ECO Reproductive Health Clinic, Moscow, Russia; 2 I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia; 3 Institute of Solid State Physics, Russian Academy of Sciences, Chernogolovka, Russia; 4 Central Clinical Hospital, Russian Academy of Sciences, Moscow, Russia; 5 Department of Obstetrics, Gynecology, and Reproductive Medicine, Santo Spirito Hospital, Rome, Italy
Objective. To enhance the efficiency of diagnosis and treatment of endometrial pathology (EP) in assisted reproductive technology (ART) programs.
Patients and methods. A total of 449 patients aged 28 to 52 years were examined. All had several unsuccessful in vitro fertilization (IVF) attempts and EP. Optical spectroscopy was a special method for diagnosing the morphological and functional state of the endometrium. Laser phototherapy was a method for endometrial rehabilitation.
Results. The women with ineffective IVF and PE were found to have hypoxia and impairments in proliferation, structuredness, and metabolism in the endometrium. Laser phototherapy increased oxygenation up to the normal physiological level (in 34.2 and 38.5% of women in menstrual cycle phases I and II, respectively). Pregnancy occurred in 68.4% of women.
Conclusion. Integrated optical spectroscopy has shown to be highly effective in diagnosing the functional parameters of the endometrium, which determine its ability to implant. Laser phototherapy is a highly effective method for the rehabilitation of EP.

Keywords

endometrial pathology
infertility
impaired implantation
optical spectroscopy
oxygenation
laser phototherapy

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Received 17.01.2020

Accepted 07.02.2020

About the Authors

Vladimir M. Zuev, professor, Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University (Sechenov University).
Tel.: +7(499)248-6956. E-mail: vlzuev@bk.ru. ORCID: 0000-0001-8715-2020.
8 Trubetskaya str., Moscow, 119048, Russian Federation
Elena A. Kalinina, MD., the General Director of the clinic of reproductive health “ART-ECO”.Tel.: +7(495)665-79-09. E-mail: kalinina@art-ivf.ru.
23-1 Savvinskaya embankment, Moscow, 119435, Russian Federation
Vladimir I. Kukushkin, Institute of Solid State Physics RAS (Chernogolovka, Russia). Tel.: +7(496)522-19-82. E-mail: kukushvi@mail.ru. ORCID: 0000-0002-1329-5202.
2 Akad. Osip’yan str., Chernogolovka, 142432, Russian Federation
Tea A. Dzhibladze, Professor, Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University (Sechenov University).
Tel.: +7(499)248-6956. E-mail: djiba@bk.ru. ORCID: 0000-0003-1540-5628. 8 Trubetskaya str., Moscow, 119991, Russian Federation
Evgeny V. Zharov, Professor, Central Clinical Hospital of the Russian Academy of Sciences. Tel.: +7(499)400-47-33. E-mail: zharov@ ag-info.ru.
1A Litovsky bulvar, Moscow, 117593, Russian Federation.
Mario Montanino Oliva, PhD, Department of Obstetrics and Gynecology Santo Spirito Hospital (Rome, Italy). Tel.: +39-668352339ю
E-mail: mario.montanino@artemisia.itю ORCID:0000-0002-6250-1607. LungotevereinSaxia 1, 00193, Rome, Italy.

For citation: Zuev V.M., Kalinina E.A., Kukushkin V.I., Dzhibladze T.A., Zharov E.V., Montanino M.O. Innovative laser technologies in the diagnosis and treatment of the endometrium of concern in reproductive medicine.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 4: 157-165. (In Russian).
https://dx.doi.org/10.18565/aig.2020.4.157-165

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