Interferon inducers in the combination therapy of uterine cervical diseases in persistent human papillomavirus infection
Background. Despite the ability to visualize the type of precancer and its long period and sufficiently sensitive, specific, and inexpensive screening tests (cytology testing and determination of human papillomavirus ((HPV) with the possibility of combining them in liquid technology), the incidence of invasive cancer increases and the neglect of the latter is not reduced.Radzinsky V.E., Ordiyants I.M., Buyanova N.V., Zykov E.V.
Objective. To improve therapy for a treatment outcome for uterine cervical diseases with persistent HPV infection.
Subjects and methods. To solve the set tasks, the investigators examined 50 patients with cervical diseases and persistent HPV infection (retrospective medical history data, Pap test, HPV testing, extended colposcopy, cervicoscopy, radiosurgical conization of the cervix with subsequent morphological examination).
Results. The proposed package of measures, based on antiviral therapy with allokin-alpha and on a differentiated approach to choosing a surgical treatment, could obtain the maximum positive treatment result. The complete and incomplete effects after combination treatment were observed in 94 and 6% of the women, respectively.
Conclusion. Thus, the proposed package of measures, based on antiviral therapy with allokin-alpha and a differentiated approach to choosing a surgical treatment, could obtain the maximum positive treatment result.
Keywords
uterine cervical diseases
human papillomavirus infection
interferon inductors
Supplementary Materials
- Table. The index of HPV (Digene-test)
- Fig. 1. Typing - HPV results
- Fig. 2. Completion of epithelialization
- Fig. 3. HPV test scores DNA after treatment
References
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Received 01.12.2017
Accepted 22.12.2017
About the Authors
Radzinsky Victor Ye., Corresponding Member. RAMS, MD, professor, head of the department of Obstetrics and Gynecology with the course of perinatology, Peoples’ Friendship University of Russia. 117198, Russia, Moscow, Miklukho-Maklaya str. 6. Tel.: +79037232212. E-mail: radzinsky@mail.ruOrdiyants Irina M., Professor of the Department of Obstetrics and Gynecology with the course of Perinatology, Peoples’ Friendship University of Russia.
117198, Russia, Moscow, Miklukho-Maklaya str. 6. Tel.: +79268005036. E-mail: ordiyantc@mail.ru
Zykov Evgeniy V., post-graduate student of the Department of Obstetrics and Gynecology with the course of perinatology, Peoples’ Friendship University of Russia.
117198, Russia, Moscow, Miklukho-Maklaya str. 6. Tel.: +79161113741. E-mail: yevgeny_zykov@hotmail.com
Buyanova Natalia Vladimirovna, the competitor of the Department of Obstetrics and Gynecology with the course of Perinatology, Peoples’ Friendship University of Russia. 117198, Russia, Moscow, Miklukho-Maklaya str. 6. E-mail: bnv.doc@mail.ru
For citations: Radzinsky V.E., Ordiyants I.M., Buyanova N.V., Zykov E.V. Interferon inducers in the combination therapy of uterine cervical diseases in persistent human papillomavirus infection. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (1): 121-6. (in Russian)
https://dx.doi.org/10.18565/aig.2018.1.121-126
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