Endometrial glycome in the menstrual cycle and endometrial receptivity

Ziganshina M.M., Abdurakhmanova N.F., Pavlovich S.V., Gvozdeva A.D., Bovin N.V. Sukhikh G.T.

1 Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia; 2 Academicians M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Miklukho-Maklaya str. 16/10, Russia; 3 M.V. Lomonosov Moscow State University, Moscow 119991, Leninskie Gory, 1, Russia; 4 Department of Obstetrics, Gynecology, Perinatology, and Reproductology, Institute of Professional Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Objective. To carry out a systematic analysis of the data available in the current literature on the cyclicity of endometrial glycomic changes and their impact on receptivity and implantation.
Material and methods. The review includes the data of 46 foreign and Russian articles published in the past 22 years and found in the Pubmed database on this topic.
Results. Endometrial glycomic changes are described in relation to the phase of the menstrual cycle. The maximum glycomic changes are shown to be observed during the implantation window. The changes in the expression of endometrial epithelium glycans are demonstrated to regulate both positively and negatively implantation.
Conclusion. The endometrial glycomic differences established in the proliferative and secretory phases of the cycle suggest that glycans are involved in implantation as determinants of receptivity. The data presented may contribute to increasing knowledge on the pathogenesis of infertility and indicate the need for further investigations aimed at identifying glycans as markers for endometrial receptivity in order to enhance the effectiveness of assisted reproductive technology programs.

Keywords

glycome
glycans
endometrial receptivity
assisted reproductive technologies
glycocalyx
lectins

Supplementary Materials

  1. Fig . 1. Endometrial pattern (ENP) of the proliferative and secretory phases of the menstrual cycle, reflecting the molecular changes in endometrial tissue between the phases of the cycle ( [10 ] , with changes )
  2. Fig . 2. Schematic representation of the pattern of glycosylation of contacting cells during implantation in mammals. A - complementary glycocode, successful adhesion; B - nekomplimentarny glikokod, adhesion is not carried out
  3. Fig . 3 The expression pattern of mucin MUC 1 in the non-receptive (A) and receptive (B) endometrium

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Received 14.04.2017

Accepted 28.04.2017

About the Authors

Ziganshina Marina Mikhailovna, Ph.D., Senior Researcher, Laboratory of Clinical Immunology, Research Center of Obstetrics, Gynecology, and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail: mmz@mail.ru
Abdurakhmanova Nigora Farukhovna, post-graduate student of the 1st year of the Department of Auxiliary Technologies in Infertility Treatment, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381341. E-mail: abd.nigora@yandex.ru
Pavlovich Stanislav Vladislavovich, Ph.D., Associate Professor, Scientific Secretary of the Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; Professor of the Department of Obstetrics, Gynecology, Perinatology, and Reproductology, Institute of Professional Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954382100. E-mail: st.pavlovich@mail.ru
Gvozdeva Anna Dmitrievna, 5th-year student of the Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University.
119991, Russia, Moscow, Leninskie Gory, 1. Tel.: +74959391000. E-mail: gvozdevaannalech@gmail.com
Bovin Nikolai Vladimirovich, Doctor of Chemical Sciences, Professor, Head of the Department of Laboratory of Carbohydrate Chemistry, Academicians M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
117997, Russia, Moscow, Miklukho-Maklaya str. 16/10. Tel.: +74953307138. E-mail: professorbovin@yandex.ru
Sukhikh Gennady Tikhonovich, Academician of the Russian Academy of Sciences, MD, Professor, Honored Scientist of the Russian Federation, Director of the Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; Professor of the Department of Obstetrics, Gynecology, Perinatology, and Reproductology, Institute of Professional Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail: gtsukhikh@mail.ru

For citations: Ziganshina M.M., Abdurakhmanova N.F., Pavlovich S.V., Gvozdeva A.D., Bovin N.V. Sukhikh G.T. Endometrial glycome in the menstrual cycle and endometrial receptivity. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (12): 17-24. (in Russian)
https://dx.doi.org/10.18565/aig.2017.12.17-24

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