Endometrial hyperplastic processes: etiopathogenesis, risk factors, polymorphism of candidate genes

DOI

https://dx.doi.org/10.18565/aig.2019.1.13-18

Ponomarenko I.V., Polonikov A.V., Churnosov M.I.
1 Belgorod State National Research University, Belgorod, Russia 2 Kursk State Medical University, Ministry of Health of Russia, Kursk, Russia

Objective. To carry out a systems analysis of the data available in the current literature on the etiopathogenesis, risk factors, and genetic determinants of endometrial hyperplastic processes.
Materials and methods. The review includes the updates of foreign and Russian articles found in Pubmed on this topic.
Results. The paper presents the basic etiopathogenetic mechanisms of endometrial hyperplasia, their risk factors, and genetic determinants.
Conclusion. According to modern concepts, endometrial hyperplastic processes are a multifactorial disease, the development of which involves the processes of hormone-dependent and hormone-independent endometrial cell proliferation, chronic inflammation, as well as genetic and epigenetic mechanisms.

endometrial hyperplasia

etiology

pathogenesis

risk factors

polymorphism of candidate genes

Full text (in Russian)

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Received 12.03.2018

Accepted 20.04.2018

Ponomarenko, Irina V., MD, associate professor of the Department of Biomedical Disciplines of the Medical Institute, Belgorod State National Research University.
308015, Russia, Belgorod, Pobedy str. 85. Tel.: +74722301383. E-mail: ponomarenko_i@bsu.edu.ru. https://orcid.org/0000-0002-5652-0166
Polonikov, Alexey V., MD, professor, head of the Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Ministry of Health of Russia.
305041, Russia, Kursk, K. Marx str. 3. Tel.: +74712588147. E-mail: polonikovav@kursksmu.net.
Churnosov Mikhail Ivanovich, MD, professor, head of the Department of Biomedical Disciplines Medical Faculty, Belgorod State National Research University.
308015, Russia, Belgorod, Pobedy str. 85. Tel.: +74722301383. E-mail: churnosov@bsu.edu.ru. http://orcid.org/0000-0003- 1254-6134

For citations: Ponomarenko I.V., Polonikov A.V., Churnosov M.I. Endometrial hyperplastic processes: etiopathogenesis, risk factors, polymorphism of candidate genes. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (1): 13-8. (in Russian)
http://dx.doi.org/10.18565/aig.2019.1.13-18

Endometrial hyperplastic processes: etiopathogenesis, risk factors, polymorphism of candidate genes

Ponomarenko I.V., Polonikov A.V., Churnosov M.I.

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