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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2021№3
Endometriosis and cancer

Endometriosis and cancer

DOI
https://dx.doi.org/10.18565/aig.2021.3.12-17

Muftaydinova Sh.K., Buralkina N.A., Faizullin L.Z.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Based on the data of foreign and Russian articles, this review comparatively analyzes the pathogenesis of endometriosis and cancer. It has been established that endometriosis, especially its infiltrative forms, has many properties in common with cancer: uncontrolled growth and multifocal localizations of endometrioid implants, reduced apoptosis, metastasis to the lymph nodes and spread inside and outside the abdominal cavity, penetration into the surrounding tissues, stimulation of non-angiogenesis, as well as chronic inflammation and oxidative stress. The endometrioid implants show genetic and epigenetic mutations involved in oncogenic transformation. Enhanced angiogenesis required for cell growth is the most important sign of a malignant tumor. The same increased level of angiogenic factors is also found in the tissues of deep infiltrative endometriosis. Antiangiogenic therapy effectively suppresses endometrioid tissue growth and reduces pain. Women with endometriosis have an increased incidence of malignant neoplasms, which indicates the similarity of their pathogenesis and common environmental molecular and genetic risk factors.
Conclusion. When aggregating these data, it becomes possible to consider endometriosis in the context of oncogenesis, which opens up new possibilities of drug therapy.

Keywords

endometriosis
cancer
apoptosis
metastasis
Full text (in Russian)

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Received 19.11.2020

Accepted 12.01.2021

About the Authors

Shakhnoza K. Muftaydiniva, PhD student, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +7(967)133-42-08. E-mail: shaxnozka_87@mail.ru. 4, Oparina str., Moscow, 117997, Russia.
Natalia A. Buralkina, Dr. Med. Sci., senior researcher, Surgical Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +7(926)405-62-83. E-mail: n_buralkina@oparina4.ru. 4, Oparina str., Moscow, 117997, Russia.
Leonid Z. Faizullin, Cand. Bio. Sci., leading researcher, Laboratory of Molecular Genetic Methods, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +7(916)710-67-89. E-mail: l_faizullin@oparina 4. 4, Oparina str., Moscow, 117997, Russia.

For citation: Muftaydinova Sh.K., Buralkina N.A., Faizullin L.Z. Endometriosis and cancer.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 3: 12-17 (in Russian)
https://dx.doi.org/10.18565/aig.2021.3.12-17

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