Efficiency of metabolic therapy in the mother-fetus system and offspring in hypoxic states in the experiment
Objective. To carry out experiments to study of eltacin as an agent to prevent and protect a mother rat, its fetus and offspring from hypoxic damages.Sheveleva G.A., Fedorova T.A., Chirkova E.M., Nartsissov Ya.R., Podoprigora G.I.
Material and methods. Experiments were carried out in 66 pregnant outbred albino rats, their fetuses and offspring; to model various hypoxic states, the female rats were given an aqueous solution of eltacin at a dose of 6 mg/kg per os at 16 to 20 days of pregnancy.
Results. Models of the perfused rat heart, acute and chronic hemic hypoxia, resistance to acute hypoxia in female rats and their offspring when increasing altitude, and anoxia of an isolated fetus have shown that eltacin has pronounced antihypoxic properties in the mother rat, its fetus and offspring in case of oxygen deficiency.
Conclusion. The experiments have demonstrated that eltacin as part of combination therapy is a promising energizing antihypoxant in obstetric practice.
Keywords
eltacin
hypoxia
pregnancy
fetus
offspring
Supplementary Materials
- Тable 1. Eltacine’ influence on the functional-methabolic status of the perfused heart of the rat in hypoxic condition during 16 till 20 gestation’ day using dose 6 mg/kg
- Table 2. Correcting properties of Eltacine relating to embryo in condition of chronical hemic hypoxia and anoxia.
- Table 3. Individual hypoxia’ resistance of the rat’ offspring after Eltacine’ introduction 6 (mg/кg) during the fetal period of pregnancy.
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Received 08.11.2016
Accepted 11.11.2016
About the Authors
Sheveleva Galina A., Sc.D., Consultant, Department of Immunology and Transfusion blood harvesting, Research Center of Obstetrics, Gynecology, and Perinatology,Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79165180678. E-mail: shewelewa.gal@yandex.ru
Fedorova Tatyana A., Doctor of Medical Sciences, Professor, Head of the Department of Transfusion and extracorporeal blood correction, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954387135. E-mail: tfedorova 1@mail.ru
Chirkova Elena M., PhD, Senior Researcher, Research Institute of Cytochemistry and Molecular Biology.
115404, Russia, Moscow, 6th Radialnaya str. bld. 24-14. Tel.: +74956887037
Narzissov Yaroslav R., Candidate of Physical and Mathematical Sciences, associate professor, head of the department of mathematical modeling and statistical analysis, Research Institute of Cytochemistry and Molecular Biology. 115404, Russia, Moscow, 6th Radialnaya str. bld. 24-14. Tel.: +79852335004. E-meil: yarosl@biotic.dol.ru
Podoprigora Gennady I., Doctor of Medical Sciences, professor, member of RAMTS, director of the Research Institute of Cytochemistry and Molecular Biology.
115404, Russia, Moscow, 6th Radialnaya str. bld. 24-14. Tel.: +79165572028. E-mail: gipodoprigora@yandex.ru
For citations: Sheveleva G.A., Fedorova T.A., Chirkova E.M., Narzissov Ya.R., Podoprigora G.I. Efficiency of metabolic therapy in the mother-fetus system and offspring in hypoxic states in the experiment. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (2): 46-50. (in Russian)
http://dx.doi.org/10.18565/aig.2017.2.46-50
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