Efficacy of indole carbinol in patients with simple endometrial hyperplasia without atypia in perimenopause

Artymuk N.V., Kharenkova E.L., Tachkova O.A.

1) Kemerovo State Medical University, Ministry of Health of Russia, Kemerovo, Russia; 2) S.V. Belyaev Kemerovo Regional Hospital, Kemerovo, Russia
Objective. To assess whether indole carbinol can be used to treat perimenopausal patients with simple endometrial hyperplasia without atypia.
Subjects and methods. A study group (Group 1) included 34 perimenopausal women with simple endometrial hyperplasia without atypia; a comparison group (Group 2) consisted of 34 patients without proliferative endometrial diseases. Group 1 (twenty patients) was treated with indole carbinol at a dose of 300 mg/day for 3 months. Pelvic ultrasonography and hysteroscopy with endometrial biopsy were performed and the urinary levels of 2-hydroxyestrone (2-OHE1) and 16α-hydroxyestrone (16α-OHE1) were measured by enzyme immunoassay using the Estramet 2/16 Elisa kit (USA) according to the standard procedure in the patients of both groups before treatment and in those of Group 1 after treatment. The results obtained were statistically processed using the Excel, Statistica 6.0, and SISA programs (http://home.clara.net/sisa/).
Results. The histological study of endometrial aspiration after a 3-month indole carbinol treatment cycle showed the absence of endometrial hyperplasia in 100%. After indole carbinol treatment, there was a significant increase in the 2OHE1/16αOHE1 ratio relative to its initial value. There was a statistically significant decrease in 16α-OHE1 levels from 35.58±14.84 ng/mg before treatment to 20.05±3.5 ng/mg after treatment (p = 0.0001).
Conclusion. In perimenopausal women, the use of indole carbinol is accompanied by a decrease in the level of 16α-OHE1 metabolite and by an increase in the 2-OHE1/16α-OHE1 ratio and can be an effective treatment for simple endometrial hyperplasia without atypia.

Keywords

perimenopause
endometrial hyperplasia
indole carbinol
metabolites of estrogens

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Received 16.01.2020

Accepted 07.02.2020

About the Authors

Natalya V. Artymuk, MD, PhD, Professor, the Head of the Department of Obstetrics and Gynecology named after Professor G.A. Ushakova of the Kemerovo State Medical University of the Ministry of Health of Russia. Tel.: +7(960)9233355. E-mail: artymuk@gmail.com; ORCID 0000-0001-7014-6492
Address: 650029, Russia, Kemerovo, Voroshilov Str, 22a.
Ekaterina L. Kharenkova, MD, PhD, Gynecological Department No. 2 of the Kemerovo Region Clinical Hospital named after S.V. Belyaev. Tel.: + 7(344)2396533.
E-mail: Caty-20@rambler.ru
650066, Russia, Kemerovo, 22A Oktyabrsky Ave.
Olga A. Tachkova, MD, PhD, Associate Professor at the Department of Hospital Therapy and Clinical Pharmacology, Kemerovo State Medical University, Ministry of Health of the Russian Federation, Kemerovo, Russia. Tel.:+ 7(909)5174932. E-mail: ol.an.t@yandex.ru, ORCID 0000-0002-6537-3460
Address: 650029, Russia, Kemerovo, Voroshilov Str, 22a.

For citation: Artymuk N.V., Kharenkova E.L., Tachkova O.A. Efficacy of indole carbinol in patients with simple endometrial hyperplasia without atypia in perimenopause.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 2: 154-9. (In Russian).
https://dx.doi.org/10.18565/aig.2020.2.154-159

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