Changes in the indicators of cytokine status and autoimmunity in female patients with latent forms of human papillomavirus infection

DOI

https://dx.doi.org/10.18565/aig.2020.9.225-232

Tkachenko L.V., Sviridova N.I., Shishimorova S.G., Deleske I.A.
Volgograd State Medical University, Ministry of Health of Russia, Volgograd, Russia

Objective. To study the impact of immunostimulating therapy on changes in the indicators of local cytokine status and autoimmunity in female patients with latent forms of human papillomavirus infection (PVI).
Materials and methods. Clinical and laboratory examinations were made in 96 patients aged 18 to 45 years with the latent forms of PVI. A study group consisted of 48 patients who underwent follow-up and a differentiated approach to using the immunostimulating and antiviral drug Inosine pronabex 1000 mg thrice daily for 28 days. A comparison group included 48 women who underwent co-testing at 12 months after the start of the follow-up.
Results. Analyzing the outcomes of latent forms of PVI following 12 months showed that in the study group, there was a complete elimination of human papillomavirus (HPV) and a clinically insignificant viral load in 95.8% of cases, which was 1.5 times more often than in the comparison group. Moreover, in the latter group, every three (35.5%) patients had a "significant" high-risk HPV concentration.
Conclusion. Immunostimulating and antiviral therapy with Groprinosin-Richter in patients with latent forms of PVI leads to elimination of the initial imbalance of cytokines and to normalization of autoantibody levels, which suggests that the local inflammatory changes in the cervical epithelium are eliminated, and, as a result, the reproductive potential is preserved.

latent forms of papillomavirus infection

human papillomavirus

inosine pranobex

Full text (in Russian)

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Received 22.05.2020

Accepted 08.09.2020

Lyudmila V. Tkachenko, Doctor of Medical Sciences, Professor, Head Department of Obstetrics and Gynecology, Faculty of Advanced Medical Studies,
Volgograd State Medical University, Ministry of Health of Russia. Теl.: +7(8442)34-11-05. E-mail: tkachenko.fuv@mail.ru.
400131, Russia, Volgograd, pl. Fallen fighters, 1.
Natalia I. Sviridova, Doctor of Medical Sciences, Associate Professor, Professor of the Department of Obstetrics and Gynecology,
Faculty of Advanced Training of Doctors, Volgograd State Medical University, Ministry of Health of Russia. Теl.: +7(8442)34-11-05. E-mail: n.i.sviridova@yandex.ru.
400131, Russia, Volgograd, pl. Fallen fighters, 1.
Svetlana G. Shishimorova, a graduate student in the Department of Obstetrics and Gynecology at the Faculty of Advanced Training of Doctors
of Volgograd State Medical University, Ministry of Health of Russia. Теl.: +7(8442)34-11-05. E-mail: trigerz@mail.ru.
400131, Russia, Volgograd, pl. Fallen fighters, 1.
Inna A. Deleske, a graduate student in the Department of Obstetrics and Gynecology, Institute of Continuing Medical and Pharmaceutical Education,
Volgograd State Medical University, Ministry of Health of Russia. Теl.: +7(8442)34-11-05. E-mail: deleske25@mail.ru.
400131, Russia, Volgograd, pl. Fallen fighters, 1.

For citation: Tkachenko L.V., Sviridova N.I., Shishimorova S.G., Deleske I.A. Changes in the indicators of cytokine status and autoimmunity in female patients with latent forms of human papillomavirus infection.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 9: 225-232 (in Russian)
https://dx.doi.org/10.18565/aig.2020.9.225-232

Changes in the indicators of cytokine status and autoimmunity in female patients with latent forms of human papillomavirus infection

Tkachenko L.V., Sviridova N.I., Shishimorova S.G., Deleske I.A.

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