Favorable maternal and perinatal outcomes of pregnancy in a COVID-19 patient with total lung damage
Background: The course and prognosis of the novel coronavirus infection (SARS-CoV-2) in pregnant women are unpredictable; at the same time, the clinical presentation can be vague and non-specific; a critical condition can suddenly develop in the presence of the stable course of the disease. In the literature, there are data on survival rates with 100% lung damage caused by SARS-CoV-2 delta variant; however, the experience of managing pregnant women with total lung damage is not presented.Tezikov Yu.V., Tezikova T.A., Lipatov I.S., Nechayeva M.V., Yakusheva A.O., Tyutyunnik V.L., Kan N.E.
Case report: A female patient was admitted to the hospital at 33 weeks of gestation on day 7 of the novel coronavirus infection (SARS-CoV-2). On the 4th day of inpatient treatment, there was a progressive deterioration in the condition of the pregnant woman with a complication as severe bilateral polysegmental interstitial pneumonia. She received combined antibacterial, glucocorticoid, hepatoprotective, infusion, anticoagulant therapy and non-invasive ventilation with the postpartum transition to mechanical ventilation. Taking into consideration the signs of progressive fetal hypoxia, her baby was delivered by cesarean section. The boy was alive premature who had signs of morphofunctional immaturity. After 88 days of inpatient treatment (49 days after 100% lung disease), the female patient was discharged with respiratory support with humidified O2 using a portable concentrator. The patient had been in the intensive care unit for 65 days, of which 46 days on mechanical ventilation. The newborn was discharged home in a satisfactory condition. The clinical case demonstrates favorable gestational and perinatal outcomes with 100% lung involvement, as evidenced by computed tomography. Management of a near-miss pregnant or puerperant woman required an interdisciplinary approach. Specialists used the possibilities of telemedicine for consulting the patients.
Conclusion: The accumulation of knowledge and clinical experience in the management of pregnant and puerperant women with SARS-CoV-2 and total lung tissue damage will undoubtedly be able to optimize medical strategies and to prevent maternal and perinatal critical conditions and deaths.
Keywords
pregnancy
coronavirus infection
SARS-CoV-2
total lung involvement
postpartum endometritis
gestational and perinatal outcomes
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Received 17.02.2022
Accepted 20.04.2022
About the Authors
Yurii V. Tezikov, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine, Samara State Medical University,Ministry of Healthcare of Russian Federation, +7(927)685-44-85, yra.75@inbox.ru, ORCID ID: 0000-0002-8946-501X, Researcher ID: С-6187-2018, SPIN-код: 2896-6986, Author ID: 161372, Scopus Author ID: 6603787595, 443099, Russia, Samara, Chapaevskaya str., 89.
Tatiana A. Tezikova, Deputy Chief Physician for Obstetrics and Gynecology, Perinatal Center of Samara Regional Clinical Hospital named after V.D. Seredavin,
+7(927-263-39-94, t-tezikova@mail.ru, ORCID ID: 0000-0001-9747-9588, 443095, Russia, Samara, Tashkentskaya str., 159.
Igor S. Lipatov, Dr. Med. Sci., Professor; Professor at the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine, Samara State Medical University,
Ministry of Healthcare of Russian Federation, +7(927)262-92-70, i.lipatoff2012@yandex.ru, ORCID ID: 0000-0001-7277-7431, Researcher ID: С-5060-2018,
SPIN-код: 9625-2947, Author ID: 161371, Scopus Author ID: 6603787595, 443099, Russia, Samara, Chapaevskaya str., 89.
Marina V. Nechaeva, Head of the Reception Department, Perinatal Center of Samara Regional Clinical Hospital named after V.D. Serdavin, +7(927)740-64-31,
m.v.necevaha@samsmu.ru, 443095, Russia, Samara, Tashkentskaya str., 159.
Anastasia O. Yakusheva, Resident of the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine, Samara State Medical University, Ministry of Healthcare of Russian Federation, +7(846)958-24-18, yakusheva.nastya1996@gmail.com, ORCID ID: 0000-0001-7246-1146, 443099, Russia, Samara, Chapaevskaya str., 89.
Victor L. Tyutyunnik, Dr. Med. Sci., Professor, Leading Researcher of Research and Development Service, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, +7(903)969-50-41, tioutiounnik@mail.ru, Researcher ID: B-2364-2015,
SPIN-код: 1963-1359, Authors ID: 213217, Scopus Author ID: 56190621500, ORCID ID: 0000-0002-5830-5099, 117997, Russia, Moscow, Ac. Oparina str., 4.
Natalia E. Kan, Dr. Med. Sci., Professor, Deputy Director of Science, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, +7(926)220-86-55, kan-med@mail.ru, Researcher ID: B-2370-2015, SPIN-код: 5378-8437,
Authors ID: 624900, Scopus Author ID: 57008835600, ORCID ID: 0000-0001-5087-5946, 117997, Russia, Moscow, Ac. Oparina str., 4.
Authors' contributions: Tezikov Yu.V., Tezikova T.A., Nechaeva M.V. – material collection and processing; Lipatov I.S., Nechaeva M.V., Yakusheva A.O. – collection of publications on the topic of the article, writing the text of the article; Tezikov Yu.V., Tyutyunnik V.L., Kan N.E. – the concept and design of the article, editing.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has not been sponsored.
Ethical Approval: The investigation has been approved by the Ethics Committee, Samara State Medical University, Ministry of Health of Russia.
Patient Consent for Publication: The patient provided informed consent for the publication of her data.
For citation: Tezikov Yu.V., Tezikova T.A., Lipatov I.S., Nechayeva M.V., Yakusheva A.O., Tyutyunnik V.L., Kan N.E. Favorable maternal and perinatal outcomes of pregnancy in a COVID-19 patient with total lung damage.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 5: 171-178 (in Russian)
https://dx.doi.org/10.18565/aig.2022.5.171-178
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