Biological markers for the effects of reproductive toxicants in working women

Marinkin I.O., Shpagina L.A., Kotova O.S., Panacheva L.A., Khayatova Z.B., Evchenko V.V.

1) Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia; 2) City Clinical Hospital Two, Novosibirsk, Russia
The paper analyzes the results of recent studies of the influence of a chemical factor in the working environment on the female reproductive health. The review includes the authors’ own investigations and the results of a search in the e.LYBRARY, PubMed, and Embase databases. The health risks to working women are still high in the conditions of modern production. The most significant adverse factors are reproductive toxicants that affect the health not only of the woman herself, but also her subsequent generations. The possible consequences of exposure are disorders of the ovarian-menstrual cycle, infertility, complications of pregnancy and childbirth, cancer, endometriosis, and others. The timely detection of maladaption to chemical exposure is particularly important for occupational health risk management, which determines the relevance of biomarker studies.

Keywords

reproductive health
pregnancy and labor complications due to occupational exposures
cancers related to occupational exposures
biological markers

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Received 01.04.2019

Accepted 19.04.2019

About the Authors

Igor O. Marinkin, MD, PhD, Professor, Honored Doctor of the Russian Federation, Rector of Novosibirsk State Medical University, Head of the Department of Obstetrics and Gynecology of Novosibirsk State Medical University. Phone +7 (383) 2223204 e-mail mkb-2@yandex.ru
Address 52, Krasny Prospect, Novosibirsk, Russian Federation 630091
Lyubov A. Shpagina, MD, PhD, Professor, Honored Doctor of the Russian Federation, Head of the Department of Internal medicine and medical rehabilitation of Novosibirsk State Medical University. Head doctor of Novosibirsk City Hospital №2. ORCID ID: https://orcid.org/0000-0003-0871-7551 Phone. +7(383)2799945,
e-mail: mkb-2@yandex.ru
Address 21, Polzunova street, Novosibirsk, Russian Federation 630051;
Olga S. Kotova, MD, PhD assistant professor of the Department of Internal medicine and medical rehabilitation of Novosibirsk State Medical University; therapist of Novosibirsk City Hospital №2. ORCID ID: https://orcid.org/0000-0003-0724-1539 Phone. +7(383)2799945, e-mail: ok526@yandex.ru
Address 21, Polzunova street, Novosibirsk, Russian Federation 630051.
Lyudmila A. Panacheva MD, PhD, Professor of the Department of Internal medicine and medical rehabilitation of Novosibirsk State Medical University; therapist of Novosibirsk City Hospital №2.
Address 21, Polzunova street, Novosibirsk, Russian Federation 630051.
Zulfiya B. Hayatova MD, PhD, Professor of the Department of Obstetrics and Gynecology of Novosibirsk State Medical University. Phone +7 (383) 2223204
e-mail mkb-2@yandex.ru
Address 52, Krasny Prospect, Novosibirsk, Russian Federation 630091
Valentina V. Evchenko gynaecologist of Novosibirsk City Hospital №2. Phone. +7(383)2799945, e-mail: mkb-2@yandex.ru
Address 21, Polzunova street, Novosibirsk, Russian Federation 630051.

For citation: Marinkin I.O., Shpagina L.A., Kotova O.S., Panacheva L.A., Khayatova Z.B., Evchenko V.V. Biological markers for the effects of reproductive toxicants in working women.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (10): 43-50. (in Russian).
http://dx.doi.org/10.18565/aig.2019.10.43-50

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