Anesthetic management of open fetal surgery to correct spina bifida
Background. Today, open fetal surgery is a rare intervention, the main goal of which is to correct intrauterine fetal malformations. Studies have provided evidence that intrauterine correction of spina bifida reduces the incidence and severity of neurological disorders, compared with the standard surgical treatment for newborns. Anesthetic management of open fetal surgery is complex and differs from the standard anesthesia management during pregnancy.Ostrik K.A., Pyregov A.V., Gladkova K.A., Kostyukov K.V., Shmakov R.G.
Case report. The paper describes two clinical cases of anesthesia of an open fetal surgical intervention for congenital malformation – myelomeningocele (spina bifida). The surgery was performed in the second trimester of pregnancy. Pregnant women underwent combined anesthesia with high doses of an inhalation anesthetic. This clinical case demonstrates the features of anesthesia and the approach to choosing the tactics for anesthetic management of open fetal surgery. It shows that such operations cannot be performed without well-coordinated work of a large multidisciplinary team of professionals.
Conclusion. Fetal surgery is a rapidly growing field of medicine. Anesthetic management of fetal surgery is developing together with progress in surgical techniques. Anesthetic management is based on knowledge of the physiology and pathophysiology of the mother and fetus. Open fetal surgery cannot be performed without the multidisciplinary teamwork of professionals, who include obstetricians/gynecologists, neurosurgeons, anesthesiologists/resuscitators, neonatologists, fetal medicine specialists, operating nurses, anesthetic nurses, and midwives; operating rooms prepared with appropriate equipment are also needed.
Keywords
open fetal surgery
general anesthesia
fetal anesthesia
fetal medicine
multidisciplinary interaction
References
- Adzick N.S., Thom E.A., Spong C.Y., Brock J.W., Burrows P.K., Johnson M.P. et al. A randomized trial of prenatal vs postnatal repair of myelomeningocele. N. Engl. J. Med. 2011; 364(11): 993-1004. https://dx.doi.org/10.1056/NEJMoa1014379.
- Committee on Obstetric Practice, Society for Maternal–Fetal Medicine. Committee Opinion No. 720: Maternal-Fetal Surgery for Myelomeningocele. Obstet. Gynecol. 2017; 130(3): e164-7. 10.1097/AOG.0000000000002303.
- Johnson M.P., Bennett K.A., Rand L., Burrows P.K.., Thom E.A., Howell L.J. et al. The Management of Myelomeningocele Study: obstetrical outcomes and risk factors for obstetrical complications following prenatal surgery. Am. J. Obstet. Gynecol. 2016; 215(6): 778. e9. https://dx.doi.org 10.1016/j.ajog.2016.07.052.
- Luo D., Wu L., Wu X, Juan V., Juan H. Anesthetic management of a newborn receiving prenatal restoration of gastroschisis. Int. J. Clin. Exp. Med. 2015; 8(5): 8234-7.
- Braden A., Maani S., Nagy S. Anesthetic management of an ex utero intrapartum treatment procedure: a novel balanced approach. J. Clin. Anesth. 2016; 31: 60-3. https://dx.doi.org/10.1016/j.jclinane.2015.12.010.
- Marquez M.V., Carneiro J., Adriano M., Lance F. Anesthesia for ex utero intrapartum treatment: renewed insight on a rare procedure. Rev. Bras. Anestesiol. 2015; 65(6): 525-8. https://dx.doi.org/10.1016/j.bjan.2013.12.002.
- Helfer D.K., Clivatti J., Yamashita A.M., Moron A.F. Anesthesia for ex utero intrapartum treatment (EXIT procedure) in fetus with prenatal diagnosis of oral and cervical malformations: case reports. Rev. Bras. Anestesiol. 2012; 62(3): 411-23. https://dx.doi.org/10.1016/S0034-7094(12)70141-1.
- Oliveira E., Pereira P., Retros S., Martires E. Anesthesia for EXIT procedure (ex utero intrapartum treatment) in congenital cervical malformation--a challenge to the anesthesiologist. Braz. J. Anesthesiol. 2015; 65(6): 529-33. https://dx.doi.org/10.1016/j.bjane.2013.07.020.
- Гурьянов В.А., Пырегов А.В., Гельфанд Б.Р., Куликов А.В. Анестезия в акушерстве. В кн.: Бунятян А.А., ред. Анестезиология. Национальное руководство. Краткое издание. М.: ГЭОТАР-Медиа; 2015: 444-63. [Guryanov V.A.,Pyregov A.V., Gelfand B.R., Kulikov A.V. Anesthesia in obstetrics. In the book: Anesthesiology Bunatyan A.A., Vashchinskaya T.V., Gelfand B.R., Guryanov V.A., Dementieva I.I., Dolbneva E.L., Dolina O.A., Evdokimov E.A.,Zaitsev A.Yu., Kozlov S.P., Kulikov A.V., Likhvantsev V.V., Lubnin A.Yu., Matveeva O.B., Mizikov V.M., Neymark M.I., Never V.V., Osipova N.A., Osipova N.A., Polushin Yu.S. et al. National leadership. Brief Edition. Moscow. 2015: 444-63. (in Russian].
- Вихарева О.Н., Баев О.Р., Михайлов А.В., Пырегов А.В., Шмаков Р.Г. Нитроглицерин для экстренного расслабления матки при затрудненном извлечении плода. В кн.: Клинические протоколы. Сборник статей. М.; 2015: 32-3. [Vikhareva O.N., Baev O.R., Mikhailov A.V., Pyregov A.V., Shmakov R.G. Nitroglycerin for emergency relaxation of the uterus with difficulty removing the fetus. In the collection: Clinical Protocols Moscow, 2015; P. 32-33. (in Russian)].
- Серов В.Н., Сухих Г.Т., Баранов И.И., Пырегов А.В., Тютюнник В.Л., Шмаков Р.Г. Неотложные состояния в акушерстве. Руководство для врачей. М.; 2013. [Serov V.N., Sukhikh G.T., Baranov I.I., Pyregov A.V., Tyutyunnik V.L., Shmakov R.G. Emergency conditions in obstetrics. A guide for doctors. М.; 2013. (in Russian)].
- Gin T., Chan M.T. Decreased minimum alveolar concentration of isoflurane in pregnant humans. Anesthesiology. 1994; 81(4): 829-32. https://dx.doi.org/10.1097/00000542-199410000-00009.
- George R.B., Melnick A.H., Rose E.C., Habib A.S. Case series: Combined spinal epidural anesthesia for Cesarean delivery and ex utero intrapartum treatment procedure. Can. J. Anaesth 2007; 54(3): 218-22. https://dx.doi.org/10.1007/BF03022643.
- Rosen M.A., Andreae M.H., Cameron A.G. Nitroglycerin for fetal surgery: fetoscopy and ex utero intrapartum treatment procedure with malignant hyperthermia precautions. Anesth. Analg. 2003; 96(3): 698-700, table of contents. https://dx.doi.org/10.1213/01.ane.0000049686.20464.3b.
- Boat A., Mahmoud M., Michelfelder E.C., Lin E., Ngamprasertwong P., Schnell B. et al. Supplementing desflurane with intravenous anesthesia reduces fetal cardiac dysfunction during open fetal surgery. Paediatr. Anaesth. 2010; 20(8): 748-56. https://dx.doi.org/10.1111/j.1460-9592.2010.03350.x.
- Laje P., Johnson M.P., Howell L.J., Bebbington M.W., Hedrick H.L., Flake A.W. et al. Ex utero intrapartum treatment in the management of giant cervical teratomas. J. Pediatr. Surg. 2012; 47(6): 1208-16. https://dx.doi.org/10.1016/j.jpedsurg.2012.03.027.
Received 02.06.2020
Accepted 06.06.2020
About the Authors
Kirill A. Ostrik, anesthesiologist-resuscitator, V.I. Kulakov NMRC for OG&P of the Ministry of Health of Russia. Tel.: +7(909)980-13-17. E-mail: Kirillplatonovich@yandex.ru.117997, Russia, Moscow, Academician Oparin str., 4.
Aleksey V. Pyregov, Doctor of Medical Sciences, Professor, Director of the Institute of Anesthesiology,
Intensive Care and Transfusiology, V.I. Kulakov NMRC for OG&P of the Ministry of Health of Russia.
Tel.: +7(916)140-65-49. E-mail: Pyregov@mail.ru. 117997, Russia, Moscow, Academician Oparin str., 4.
Kristina A. Gladkova, Ph.D., senior researcher, Department of Fetal Medicine, Institute of Obstetrics, Head of the 1st Obstetric Department of Pregnancy Pathology,
V.I. Kulakov NMRC for OG&P of the Ministry of Health of Russia. Tel.: +7(916)321-10-07. E-mail: oeluneke@gmail.com. 117997, Russia, Moscow, Academician Oparin str., 4.
Kirill V. Kostyukov, MD, PhD, senior researcher, Department of Fetal Medicine, Institute of Obstetrics, Physician, Department of Functional and Ultrasound Diagnostics, Department of Visual Diagnostics, V.I. Kulakov NMRC for OG&P of the Ministry of Health of Russia.
Tel.: +7(926)214-97-84. E-mail:kosrykov_k@yahoo.com. 117997, Russia, Moscow, Academician Oparin str., 4.
Roman G. Shmakov, Doctor of Medical Sciences, Professor of the Russian Academy of Sciences, Director of the Institute of Obstetrics,
V.I. Kulakov NMRC for OG&P of the Ministry of Health of Russia. E-mail: mdshmakov@mail.ru. 117997, Russia, Moscow, Academician Oparin str., 4
For citation: Ostrik K.A., Pyregov A.V., Gladkova K.A., Kostyukov K.V., Shmakov R.G. Anesthetic management of open fetal surgery to correct spina bifida.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 9: 255-261 (in Russian).
https://dx.doi.org/10.18565/aig.2020.9.255-261