Plasma miRNA expression levels in women with preeclampsia and chronic arterial hypertension in the first trimester of pregnancy
11.12.2025
18:02
Russian researchers conducted a study aimed to investigate the expression of several miRNAs in the plasma of patients with chronic arterial hypertension (CAH) without preeclampsia and pregnant women with CAH-associated preeclampsia (CAP) during the first trimester of pregnancy.
The study included 100 patients: Group 1 (n=58) comprised pregnant women with CAH without preeclampsia, and Group 2 (n=42) included women with CAP. The plasma expression levels of 11 miRNAs were assessed in these patients at 12–14 weeks of gestation using quantitative real-time polymerase chain reaction.
Women with CAP exhibited contrasting changes in the expression of five out of 11 plasma miRNAs compared to the group without CAP. The expression levels of miRNA-20a (p<0.001) and miRNA-181a (p<0.001) were significantly decreased in the CAP group. Conversely, the expression levels of miRNA-221 (p<0.001), miRNA-146a (p=0.02), and miRNA-210 (p=0.041) were higher in this group than in women who did not develop preeclampsia.
Statistically significant changes in the expression levels of several miRNAs associated with cardiovascular pathology and placental dysfunction were identified in the first trimester of pregnancy in patients with CAH and CAP.
