Antiphosphatidylserine/prothrombin complex antibodies in patients with healthy pregnancies

A study of serum aPS/PT IgG and IgM levels was conducted in 50 pregnant women with normal pregnancies during the first, second, and third trimesters of gestation.

The median level of aPS/PT IgG in pregnant women during the first trimester was 3.77 (2.67; 5.72) U/ml; in the second trimester, it was 3.48 (2.93; 5.39) U/ml; and in the third trimester, it was 3.72 (3.02; 4.79) U/ml. The median level of aPS/PT IgM in these patients was 3.6 (2.61; 5.09) U/ml in the first trimester; 4.1 (2.65; 5.4) U/ml in the second trimester; and 5.0 (3.41; 6.38) U/ml in the third trimester. Statistically significant changes were observed only in the third trimester (p=0.018).

The scientific community recognizes aPS/PT among non-criterial phospholipid antibodies as a promising diagnostic marker that may enhance the effectiveness of antiphospholipid syndrome diagnosis. Further studies involving patients with complicated pregnancies are needed to determine the significance of aPS/PT and confirm their potential use in the clinical practice of obstetricians and gynecologists.

V.V. ISCHUK, S.B. KERCHELAEVA, E.N. ALEKSANDROVA, A.A. NOVIKOV, I.Z. KHASHUKOEVA ANTIPHOSPHATIDYLSERINE/PROTHROMBIN COMPLEX ANTIBODIES IN PATIENTS WITH HEALTHY PREGNANCIES