The cluster approach to assessment of the subgingivingual microbiome composition in women with adverse pregnancy outcomes
07.11.2025
15:42
Russian researchers conducted a study aimed to develop optimal approach to assessment of the clinical features of the gestational process and the role of associations of the members of the subgingival microbiome in the development of pregnancy complications associated with inflammatory changes in periodontium.
The study found relationship between systemic manifestations of periodontal diseases and preterm birth, low birth weight. There was statistically significant relationship between these complications and gingivitis.
The obtained results support the hypothesis that the microbiome of periodontal tissues plays one of the leading roles in the development of systemic effects in pregnant women.
The cluster approach to evaluate formation of different associations of periodontopathogens and concomitant microorganisms makes it possible to confirm their special pathogenic role in the development of systemic effects associated with periodontal diseases (gingivitis), as well as to suggest that two microbial associations (Tannerella forsythia + Prevotella intermedia and Tannerella forsythia + Treponema denticola + Candida albicans) have informative significance in involvement in the systemic reaction in the reproductive system of pregnant women.
The obtained results will be useful for obstetricians and gynecologists in managing pregnant women at risk for complications associated with periodontal diseases, and can be a perspective for further research in this area.
