Rationale for using clinical indicators to stratify pregnant women according to risk of preeclampsia severity
17.02.2025
17:14
Russian researchers conduct the study aimed to evaluate the feasibility of using clinical indicators to stratify pregnant women based on preeclampsia severity.
A comparative analysis of high-risk factors for preeclampsia, timing of preeclampsia manifestation, concomitant pregnancy complications, and diagnostic criteria for preeclampsia revealed a lack of predictive capability of the indicators regarding the severity of this pregnancy complication. Analysis of the examination findings using descriptive statistics, univariate and multivariate logistic regression, ROC analysis, and clinical epidemiology tests enabled the development of a prognostic risk stratification model for identifying pregnant women at a high risk of developing severe preeclampsia. The most effective variables were the pathological types of 24h blood pressure and quantitative assessment of nocturia. Calculation of the main performance characteristics of clinical epidemiology showed a higher prognostic significance of the model compared to individual clinical criteria (Se=85.3%, Sp=79.2%, p<0.001).
A comprehensive clinical approach to predicting severe preeclampsia using the calculation of an integral indicator, has proven its validity and potential for timely diagnosis of early clinical manifestations of the pathological process. This ensures a rational choice of obstetric strategies and addresses the critical issue of preventing life-threatening obstetric complications.
