Predictors of spontaneous puberty and premature ovarian insufficiency in girls with turner syndrome

In the presence of preserved ovarian function, sexual development in girls with TS occurs concurrently with that in the general population and is unaffected by karyotype variants. The risk of premature ovarian insufficiency (POI) in TS increases with a monosomic karyotype up to the age of 18 years and decreases in the presence of the 46,XX cell lineage in peripheral blood lymphocytes. A decline in ovarian function in most girls with TS was observed before the age of 15 years, with half of the cases occurring before the age of spontaneous puberty. This decline occurs earlier in X monosomy cases than in other karyotypic variants. An ultrasound ovarian volume of less than 1.29 cm³ is a predictor of POI in girls with TS during puberty. Therefore, it is essential to evaluate ovarian function in girls with TS by the age of 10 years, the age of expected SP, and to monitor it dynamically. This evaluation should consider the combined determination of POI markers significant for this condition: FSH levels, presence of AMH, and ovarian volume based on ultrasound data.

Turchinets A.I., Uvarova E.V., Kumykova Z.Kh., Mamedova F.Sh. Predictors of spontaneous puberty and premature ovarian insufficiency in girls with Turner syndrome.