New approaches to the treatment of post-cesarean endometritis
21.05.2025
16:48
Russian researchers conducted a study aimed to enhance treatment outcomes for patients with postpartum endometritis using molded carbon polyvinylpyrrolidone-modified sorbent VNIITU-1 PVP, in conjunction with irrigation of the uterine cavity using antiseptic solutions cavitated by low-frequency ultrasound.
Patients in group A (n=48) received injections of molded carbon polyvinylpyrrolidone-modified sorbent (VNIITU-1 PVP) into the uterine cavity. The patients in group B (n=61) received traditional antibacterial therapy. Patients in group C (n=15) underwent combined irrigation of the uterine cavity with an antiseptic solution cavitated using low-frequency ultrasound, followed by intrauterine administration of the modified sorbent.
A comprehensive approach using the modified sorbent VNIITU-1 PVP resulted in a 5.9-fold reduction in TNF-α levels and a 5.6-fold reduction in IL-1β levels in the endometrial aspirate (p<0.05) in group A, which was more effective than that in group B. In group A, hysterectomy was performed in 1 case compared to 14 cases in group B (2=3.904, p<0.05). In group C, ultrasound results indicated that by the 5th day, the involutional processes of the uterus were more pronounced than those in group A.
Solutions cavitated with low-frequency ultrasound enhanced the contractile ability of the uterus and created optimal conditions for the effective sorption of pathogenic microorganisms, toxins, and their decay products by the modified molded sorbent VNIITU-1 PVP.
