Analysis of genetic risk factors for endometrial hyperplasia in overweight and obese women
08.07.2025
09:35
Russian researchers from Belgorod State National Research University studied the association between single nucleotide variants (SNVs) related to body sex hormone levels and the occurrence of endometrial hyperplasia (EH) in overweight and obese women.
An association was found between SNV rs11031002 T>A in FSHB and EH across the three genetic models (p=0.001 and pperm=0.001): OR=0.45, 95% CI 0.31–0.66 (allelic model); OR=0.44, 95% CI 0.30–0.64 (additive model); OR=0.45, 95% CI 0.30–0.66 (dominant model). The minor allele A of SNV rs11031002 T>A in FSHB demonstrated a protective effect against disease development (OR<1). Additionally, SNV rs11031002 T>A in FSHB and five polymorphic loci (rs11031005, rs11031006, rs11031010, rs74485684, rs10835638) in linkage disequilibrium with it exhibit significant functionality, influencing the interaction of the FSHB gene promoter with 38 transcription factors and affecting the transcription level of the ARL14EP gene in subcutaneous adipose tissue.
Thus, SNV rs11031002 T>A in FSHB is associated with EH risk in overweight and obese women.
