ISSN 0300-9092 (Print)
ISSN 2412-5679 (Online)

The role of microRNAs that regulate oxidative stress genes in polycystic ovary syndrome

Lomteva S.V., Sagamonov A.S., Kharchenko E.Yu.

1) Southern Federal University, Rostov-on-Don, Russia; 2) Center for Human Reproduction and IVF, Rostov-on-Don, Russia; 3) Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia

Objective. To summarize the current data on microRNAs that regulate oxidative stress genes in polycystic ovary syndrome (PCOS) and to assess their diagnostic and therapeutic significance.
Materials and methods. A search was conducted for publications from 2016 to 2025 in PubMed, Scopus, Web of Science, eLIBRARY and Google Scholar, as well as in various databases including HMDD, PCOSKB and miRTargetLink 2.0, using the following keywords: PCOS, oxidative stress, antioxidants, hsa-miR, miRNA, microRNA.
Results. According to the literature and specialist databases, miR-145, miR-16, miR-323-3p and miR-324-3p are involved in the regulation of proliferation, apoptosis and steroidogenesis in the follicular complex cells in PCOS.
Conclusion. MicroRNAs associated with oxidative stress are promising candidates for the diagnostic and prognostic assessment of PCOS; however, their clinical applicability requires further validation in standardized prospective studies.

Authors’ contributions. Lomteva S.V. – developing the concept of the article and writing the text; Sagamonov A.S., 
Kharchenko E.Yu. – collecting and processing the material, writing the text. All authors approved the final version of the manuscript. The authors reviewed all the changes made and are responsible for the content, the interpretation of the data and the final conclusions.
Conflicts of interest. The authors declare that there are no conflicts of interest.
Funding. This research was carried out with the financial support from the Russian Science Foundation, 
RSF project No. 23–15-00464.
Generative Artificial Intelligence. An artificial intelligence tool was used during the preparation of the manuscript to edit the text and check the accuracy of the citations in the reference list.
For citation: Lomteva S.V., Sagamonov A.S., Kharchenko E.Yu. The role of microRNAs 
that regulate oxidative stress genes in polycystic ovary syndrome.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (7): 31-37 (in Russian)
https://dx.doi.org/10.18565/aig.2025.345

Keywords

polycystic ovary syndrome
microRNA
oxidative stress
antioxidant defense
biomarkers

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Received 28.11.2025

Accepted 26.06.2026

About the Authors

Svetlana V. Lomteva, PhD (Bio), Senior Researcher at the Laboratory of Developmental Biology and Genome Organization, Southern Federal University, 194/1 Stachki Ave., Rostov-on-Don, 344034, Russia; Embryologist, Center for Human Reproduction and IVF, 90 Bodraya str., Rostov-on-Don, 344068, Russia, +7(919)874-23-72,
embryolab61@gmail.com, https://orcid.org/0000-0002-8791-1936
Artur S. Sagamonov, PhD student, Department of Obstetrics and Gynecology No. 3, Rostov State Medical University, Ministry of Health of Russia, 29 Nakhichevansky Lane, Rostov-on-Don, 344022, Russia, +7(988)537-70-08, a.sagamonov@gmail.com, https://orcid.org/0009-0009-3668-3417
Evgenia Yu. Kharchenko, PhD student, Department of Genetics, Southern Federal University, 194/1 Stachki Ave., Rostov-on-Don, 344034, Russia, +7(928)604-31-50,
jenya.xarchenko@yandex.ru, https://orcid.org/0000-0002-4278-8575

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