Neonatal outcomes in patients with placenta ingrowth

DOI

https://dx.doi.org/10.18565/aig.2025.266

Kayumova A.V., Semenov Yu.A., Melkozerova O.A., Kinzhalova S.V., Gaeva A.I., Shakirova K.P., Makarov R.A.
Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia, Yekaterinburg, Russia

Objective: To study the characteristics of newborns’ adaptation, neonatal complications and outcomes depending on the time of delivery in patients with and without pathological placental invasion.
Materials and methods: The study comprised 69 birth and neonatal records to evaluate the early neonatal period in terms of perioperative management, blood loss volume, and neonatal intensive care, depending on the gestational age and indications for delivery: 43 cases with placenta increta and 26 cases without this pathology. Statistical analysis was based on Fisher's exact test for categorical variables and the Mann–Whitney test for quantitative variables.
Results: No statistically significant differences were found between the subgroups of patients with placenta ingrowth depending on the gestational age for the parameters studied: Apgar score at 1, 5, and 10 minutes; need for and duration of respiratory therapy; duration of antibacterial therapy; length of stay in the neonatal intensive care unit (p>0.05).
Infants born to mothers with pathological placental invasion are substantially more likely to develop severe respiratory distress syndrome, requiring mechanical ventilation and surfactant administration. No statistically significant differences in the use of antibacterial therapy were found between the study groups.
Conclusion: The delivery time in patients with placenta ingrowth depends on maternal safety management. Early elective delivery at 34 weeks of gestation (if possible), is justified, given the nature of life-threatening complications for both mother and fetus that occur with emergency delivery.

Authors’ contributions: Kayumova A.V. – study concept and design; Kayumova A.V., Gaeva A.I., Shakirova K.P. – collection and processing of material; Kayumova A.V., Kinzhalova S.V., Makarov R.A. – manuscript composition; Semenov Yu.A., Melkozerova O.A. – manuscript editing.
Conflicts of interest: The authors declare no conflicts of interest.
Funding: The study had no sponsorship support.
Ethical Approval: The study was approved by the local bioethics committee of the Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia.
Patient Consent for Publication: The patients signed informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Kayumova A.V., Semenov Yu.A., Melkozerova O.A., Kinzhalova S.V., Gaeva A.I.,
Shakirova K.P., Makarov R.A. Neonatal outcomes in patients with placenta ingrowth.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (1): 55-61 (in Russian)
https://dx.doi.org/10.18565/aig.2025.266

pathological invasion of the placenta

placenta ingrowth

neonatal complications

respiratory support

Full text (in Russian)

Nieto-Calvache A., Palacios-Jaraquemada J., Hussein A., Jauniaux E., Milani Coutinho C., Rijken M. Management of placenta accreta spectrum in low- and middle-income countries. Best Pract. Res. Clin. Obstet. Gynaecol. 2024; 94: 102475. https://dx.doi.org/10.1016/j.bpobgyn.2024.102475
Zhong W., Zhu F., Li S., Chen J., He F., Xin J. et al. Maternal and neonatal outcomes after planned or emergency delivery for placenta accreta spectrum: a systematic review and meta-analysis. Front. Med. 2021; 28(8): 731412. https://dx.doi.org/10.3389/fmed.2021.731412
Bonanni G., Lopez-Giron M., Allen L., Fox K., Silver R.M., Hobson S.R. et al. Guidelines on placenta accreta spectrum disorders: a systematic review. JAMA Netw Open. 2025; 8(7): e2521909. https://dx.doi.org/10.1001/jamanetworkopen.2025.21909
Hobson S., Kingdom J., Murji A., Windrim R.C., Carvalho J.C.A., Singh S.S. et al. No. 383-screening, diagnosis, and management of placenta accreta spectrum disorders. J. Obstet. Gynaecol. Can. 2019; 41(7): 1035-49. https://dx.doi.org/10.1016/j.jogc.2018.12.004
Morlando M., Schwickert A., Stefanovic V., Gziri M.M., Pateisky P., Chalubinski K.M. et al. Maternal and neonatal outcomes of elective and emergency cesarean section in the placenta accreta spectrum: a multinational database study. Acta Obstet. Gyneco.l Scand. 2021; 100(S1): 41-9. https://dx.doi.org/10.1111/AOGS.14120
Jauniaux E., Alfirevic Z., Bhide A.G., Belfort M.A., Burton G.J., Collins S.L. et al.; Royal College of Obstetricians and Gynaecologists. Placenta praevia and placenta accreta: diagnosis and management: Green-top Guideline No. 27a. BJOG. 2019; 126(1): e1-e48. https://dx.doi.org/10.1111/1471-0528.15306
Bartels H.C., Walsh J.M., Ní Mhuircheartaigh R., Brophy D., Moriarty J., Geoghegan T. et al. National Clinical Practice Guideline: Diagnosis and management of placenta accreta spectrum. National Women and Infants Health Programme and the Institute of Obstetricians and Gynaecologists. December 2022. Available at: https://www.hse.ie/eng/about/who/acute-hospitals-division/woman-infants/clinical-guidelines
Salmanian B., Einerson B., Carusi D., Shainker S.A., Nieto-Calvache A.J., Shrivastava V.K. et al. Timing of delivery for placenta accreta spectrum: the Pan-American Society for the Placenta Accreta Spectrum experience. Am. J. Obstet. Gynecol. MFM. 2022; 4(6): 100718. https://dx.doi.org/10.1016/j.ajogmf.2022.100718
Allen L., Jauniaux E., Hobson S., Papillon-Smith J., Belfort M.A.; FIGO Placenta Accreta Diagnosis and Management Expert Consensus Panel. FIGO consensus guidelines on placenta accreta spectrum disorders: Nonconservative surgical management. Int. J. Gynaecol. Obstet. 2018; 140(3): 281-90. https://dx.doi.org/10.1002/ijgo.12409
Nieto-Calvache A.J., Sanín-Blair J.E., Buitrago-Leal H.M., Benavides-Serralde J.A., Maya-Castro J., Rozo-Rangel A.P. et al. Colombian Consensus on the Treatment of Placenta Accreta Spectrum (PAS). Rev. Colomb. Obstet. Ginecol. 2022; 73(3): 283-316. https://dx.doi.org/110.18597/rcog.3877
RANZCOG Women’s Health Committee. Placenta accreta spectrum (PAS) (C-Obs 20). 2024. Available at: https://ranzcog.edu.au/wp-content/uploads/Placenta-Accreta-Spectrum.pdf
Obstetric Care Consensus No. 7: Placenta accreta spectrum. Obstet. Gynecol. 2018; 132(6): 259-75. https://dx.doi.org/10.1097/AOG.0000000000002983
Белоусова Т.Н., Князева Н.Ю., Голосная Г.С., Куликов И.А., Новиков М.Ю., Холичев Д.А. Особенности течения неонатального периода при врастании плаценты. Эффективная фармакотерапия. 2023; 19(44): 20-4. [Belousova T.N., Knyazeva N.Yu., Golosnaya G.S., Kulikov I.A.,Novikov M.Yu., Kholichev D.A. Features of the course of the neonatal period with placenta accretion. Effective Pharmacotherapy. 2023; 19(44): 20-4 (in Russian)]. https://dx.doi.org/10.33978/2307-3586-2023-19-44-20-24
Макухина Т.Б., Пенжоян Г.А., Модель Г.Ю., Донцова М.В. Исходы беременностей высокого риска врастания плаценты в зависимости от порядка оказания помощи при родоразрешении. Женское здоровье и репродукция. 2023; 4(59): 1-9. [Makukhina T.B., Penzhoyan G.A., Model G.Yu., Dontsova M.V. Outcomes of high-risk pregnancies with placenta accreta, depending on the order of delivery. Women's Health and Reproduction. 2023; 4(59): 1-9 (in Russian)]. https://dx.doi.org/10.31550/2712-8598-ZhZiR-2023-4-1
Toussia-Cohen Sh., Castel E., Friedrich L., Mor N., Ohayon A., Levin G. et al. Neonatal outcomes in pregnancies complicated by placenta accreta- a matched cohort study. Arch. Gynecol. Obstet. 2024; 310(1): 269-75. https://dx.doi.org/10.1007/s00404-023-07353-6
Kasraeian M., Hashemi A., Hessami K., Alamdarloo S.M., Vahdani R., Vafaei H. et al. A 5-year experience on perinatal outcome of placenta accreta spectrum disorder managed by cesarean hysterectomy in southern Iranian women. BMC Womens Health. 2021; 21(1): 243. https://dx.doi.org/10.1186/S12905-021-01389-Z
Palacios-Jaraquemada J., Basanta N., Fiorillo A., Labrousse C., Martínez M. Neonatal outcome after conservative-reconstructive surgery for placenta accreta spectrum disorders. J. Matern Fetal. Neonatal. Med. 2022; 35(25): 4994-6. https://dx.doi.org/10.1080/14767058.2021.1873944
Bartal M., Papanna R., Zachariaset N., Soriano-Calderon N., Limas M., Blackwell S.C. et al. Planned versus unplanned delivery for placenta accreta spectrum. Am. J. Perinatol. 2022; 39(3): 252-8. https://dx.doi.org/10.1055/s-0040-1714676
Liang Y., Zhang L., Bi S., Chen J., Zeng S., Huang L. et al. Risk factors and pregnancy outcome in women with a history of cesarean section complicated by placenta accreta. Matern. Fetal Med. 2022; 4(3): 179-85. https://dx.doi.org/10.1097/fm9.0000000000000142
Huang Y.C., Yang C.C. Impact of planned versus emergency cesarean delivery on neonatal outcomes in pregnancies complicated by abnormal placentation: a systematic review and meta-analysis. Medicine (Baltimore). 2023; 102(32): e34498. https://dx.doi.org/10.1097/MD.0000000000034498

Received 25.09.2025

Accepted 09.12.2025

Alena V. Kayumova, PhD, Associate Professor, Deputy Director in Obstetrics and Gynecology, Ural Research Institute of Maternity and Child Care,
Ministry of Health of Russia, 620028, Russia, Yekaterinburg, Repin str., 1, +7(982)62-32-047, kaum-doc@mail.ru, https://orcid.org/0000-0003-2685-4285
Yuri A. Semenov, Dr. Med. Sci., Associate Professor, Director, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia,
620028, Russia, Yekaterinburg, Repin str., 1, U-sirius@mail.ru, https://orcid.org/0000-0002-4109-714Х
Oksana A. Melkozerova, Dr. Med. Sci., Deputy Director for Science, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia,
620028, Russia, Yekaterinburg, Repin str., 1, abolmed1@mail.ru, https://orcid.org/0000-0002-4090-0578
Svetlana V. Kinzhalova, Dr. Med. Sci., Associate Professor, Head of the Department of Intensive Care and Reanimation, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia, 620028, Russia, Yekaterinburg, Repin str., 1, sveking@mail.ru, https://orcid.org/0000-0003-2576-6742
Alexandra I. Gaeva, Deputy Director for Pediatrics, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia,
620028, Russia, Yekaterinburg, Repin str., 1, gaeva_al@mail.ru, https://orcid.org/0009-0003-5690-0593
Ksenia P. Shakirova, PhD, Head of the Neonatal Intensive Care Department, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia,
620028, Russia, Yekaterinburg, Repin str., 1, ksushamova@gmail.com, https://orcid.org/0000-0001-8183-0089
Roman A. Makarov, PhD, Senior Researcher, Department of Intensive Care and Reanimation, Ural Research Institute of Maternity and Child Care,
Ministry of Health of Russia, 620028, Russia, Yekaterinburg, Repin str., 1, r_makarov_ekb@mail.ru, https://orcid.org/0000-0002-8067-5643;
Corresponding author: Alena V. Kayumova, kaum-doc@mail.ru

Neonatal outcomes in patients with placenta ingrowth

Kayumova A.V., Semenov Yu.A., Melkozerova O.A., Kinzhalova S.V., Gaeva A.I., Shakirova K.P., Makarov R.A.

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