Magnesium deficiency in the students of the Republic of Bashkortostan: prevalence, impact on reproductive health, and effectiveness of correction
Mingareeva K.N., Yashchuk A.G., Yashchuk K.N.
Rationale. Magnesium is known as a cofactor for over 600 enzymatic reactions and plays a key role in maintaining women's reproductive health. Magnesium deficiency is associated with dysmenorrhea, premenstrual syndrome (PMS), menstrual irregularities, and, in the long run, with pregnancy complications (preeclampsia, premature birth, fetal growth restriction). Despite its clinical significance, there is a lack of studies on the prevalence of magnesium deficiency among youth in the Republic of Bashkortostan. Given that pregravid preparation is a key period for preventing reproductive losses, timely detection and correction of magnesium deficiency in girls of early reproductive age are of primary importance.
Objective. To assess the prevalence of magnesium deficiency among students of the Republic of Bashkortostan, analyze its link with nutritional status and reproductive health indicators in girls (menstrual cycle regularity, severity of dysmenorrhea and premenstrual syndrome), and show the laboratory and clinical trends during three months of magnesium citrate therapy in patients with verified magnesium deficiency.
Materials and methods. A total of 606 students (480 girls, 126 boys) aged 15–19 were examined. Serum magnesium levels were identified (reference values 0.77–1.03 mmol/L). Menstrual cycle regularity, dysmenorrhea intensity using a visual analog scale (VAS, 0–10 points), and PMS severity using a total score (10 symptoms, 0–30 points) were assessed. Magnesium citrate (Solgar) at a dose of 400 mg of elemental magnesium per day per os was prescribed to 135 girls with hypomagnesemia (<0.77 mmol/L) for 3 months.
Results. Magnesium deficiency (<0.77 mmol/L) was detected in 240/480 (50.0%) girls and 55/126 (43.7%) boys aged 15–19. The frequency of deficiency did not differ between the age subgroups of 15–17 and 18–19 years. The median magnesium level in girls with deficiency was significantly lower than in boys: 0.64 [0.50; 0.71] versus 0.70 [0.58; 0.75] mmol/L (p<0.05). The highest frequency of magnesium deficiency was associated with regular fast food consumption (35.9%) and low intake of fruits and vegetables (27.6%).
During three months of therapy with magnesium citrate (400 mg/day) in 135 girls with hypomagnesemia, normalization of magnesium levels was achieved in 129 (95.5%) patients. The median magnesium level increased from 0.65 [0.52; 0.70] to 0.85 [0.78; 0.93] mmol/l. The intensity of dysmenorrhea according to VAS scale decreased from 7 [5; 8] to 3 [2; 5] points. The total score of PMS symptoms decreased from 18 [15; 22] to 8 [5; 12]. The proportion of girls with a regular menstrual cycle increased from 68.8% (93/135) to 95.5% (129/135)
Conclusion. Magnesium deficiency is common situation among students of the Republic of Bashkortostan and is associated with menstrual irregularities, dysmenorrhea, and PMS. Three months of magnesium citrate therapy (400 mg/day) effectively corrects the deficiency and improves indicators of reproductive health in girls aged 15–19, justifying the need for magnesium status screening as part of preconception care.
Authors’ contributions. Mingareeva K.N., Yashchuk A.G., Yashchuk K.N. – study concept and design, material collection and processing, article writing, article editing.
Conflicts of interest. The authors declare no conflicts of interests.
Funding. No external funding was received.
Ethical Approval. The study was carried out in accordance with the Declaration of Helsinki and approved by the Local Ethics Committee of the Bashkir State Medical University of the Ministry of Health of Russia (Protocol No. 1 as of January 21, 2026).
Generative Artificial Intelligence. While working on the manuscript, the authors used AI tool for editing and improving the style of the text to improve the clarity of presentation; assistance in structuring individual sections of the manuscript; assistance in formatting the bibliography.
Patient Consent for Publication. All study participants signed written informed consent for the publication of their data.
Authors' Data Sharing Statement. The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Mingareeva K.N., Yashchuk A.G., Yashchuk K.N. Magnesium deficiency in the students of the Republic
of Bashkortostan: prevalence, impact on reproductive health, and effectiveness of correction.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (6): 210-216 (in Russian)
https://dx.doi.org/10.18565/aig.2026.147
Keywords
reproductive health
magnesium
hypomagnesemia
students
dysmenorrhea
premenstrual syndrome
menstrual cycle
correction of magnesium deficiency
pregravid preparation
youth
magnesium citrate
References
- Fiorentini D., Cappadone C., Farruggia G., Prata C. Magnesium: biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency. Nutrients. 2021; 13(4): 1136. https://dx.doi.org/10.3390/nu13041136
- DiNicolantonio J.J., O’Keefe J.H., Wilson W. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart. 2018; 5(1): e000668. https://dx.doi.org/10.1136/openhrt-2017-000668
- Gröber U. Magnesium and drugs. Int. J. Mol. Sci. 2019; 20(9): 2094. https://dx.doi.org/10.3390/ijms20092094
- Maier J.A.M., Locatelli L., Fedele G., Cazzaniga A., Mazur A. Magnesium and the brain: a focus on neuroinflammation and neurodegeneration. Int. J. Mol. Sci. 2022; 24(1): 223. https://dx.doi.org/10.3390/ijms24010223
- Fritzen R., Davies A., Veenhuizen M., Campbell M., Pitt S.J., Ajjan R.A., Stewart A.J. Magnesium deficiency and cardiometabolic disease. Nutrients. 2023; 15(10): 2355. https://dx.doi.org/10.3390/nu15102355
- Майлян Д.Э., Коломиец В.В., Резниченко Н.А., Мишин В.В. Факторы риска и клинические проявления дефицита магния у женщин постменопаузального возраста с артериальной гипертензией и хронической сердечной недостаточностью. Актуальные проблемы медицины. 2021; 44(2): 162-73. https://dx.doi.org/10.52575/2687-0940-2021-44-2-162-173 [Mailyan D.E., Kolomiyets V.V., Reznichenko N.A., Mishin V.V. Risk factors and clinical manifestation of magnesium deficiency in postmenopausal women with hypertension and chronic heart failure. Challenges in modern medicine. 2021; 44(2): 162-73 (in Russian). https://dx.doi.org/10.52575/2687-0940-2021-44-2-162-173].
- Song B., Jiang M., Zhang Y., Xu Y., Wu C., Wu D. et al. Research hotpots and frontier trends of neuroprotective effects of magnesium from 1999 to 2023: a bibliometric analysis. CNS Neurosci. Therapeut. 2024; 30(2): e14597. https://dx.doi.org/10.1111/cns.14597
- Макацария А.Д., Бицадзе В.О., Солопова А.Г., Громова О.А., Корабельников Д.И., Блинов Д.В., Хизроева Д.Х., Макацария Н.А., Третьякова М.В., Акавова С.А., Ампилогова Д.М. Дефицит магния у женщин и его контроль: обзор современных представлений. Акушерство, гинекология и репродукция. 2024; 18(2): 218-30. https://dx.doi.org/10.17749/2313-7347/ob.gyn.rep.2024.512 [Makatsariya A.D.,Bitsadze V.O., Solopova A.G., Gromova O.A., Korabelnikov D.I., Blinov D.V., Khizroeva J.Kh., Makatsariya N.A., Tretyakova M.V.,Akavova S.A., Ampilogova D.M. Female magnesium deficiency and its management: review of current knowledge. Obstetrics, Gynecology and Reproduction. 2024; 18(2): 218-30 (in Russian). https://dx.doi.org/10.17749/2313-7347/ob.gyn.rep.2024.512].
- Bernardes M., Monteiro R., Martins M.J. Mineral-rich water consumption as a non-pharmacological intervention for early menopausal bone mineral density preservation and reduction of long-term fracture risk: comment on Billington et al. Osteoporos. Int. 2022; 33(2): 497-8. https://dx.doi.org/10.1007/s00198-021-06272-z
- Орлова С.В., Никитина Е.А., Балашова Н.В., Исаев А.Н., Ершов А.В., Пронина О.Е., Водолазкая А.Н., Прокопенко Е.В. Оценка скрытого дефицита магния у беременных. Медицинский совет. 2022; 16(5): 104-10. https://dx.doi.org/10.21518/2079-701X-2022-16-5-104-110 [Orlova S.V., Nikitina E.A., Balashova N.V., Isaev A.N., Ershov A.V., Pronina O.E., Vodolazkaya A.N., Prokopenko E.V. Assessment of subclinical magnesium deficiency in pregnant women. Medical Council. 2022; 16(5): 104-10 (in Russian). https://dx.doi.org/10.21518/2079-701X-2022-16-5-104-110].
- Никитина Е.А., Орлова С.В., Батышева Т.Т., Балашова Н.В., Алексеева М.В., Волкова Л.Ю., Водолазкая А.Н., Прокопенко Е.В. Фетальное программирование как тренд современной медицины: в фокусе дефицит магния. Медицинский алфавит. 2023; (29): 8-14. https://dx.doi.org/10.33667/2078-5631-2023-29-8-14 [Nikitina Е.А., Orlova S.V., Batysheva Т.Т., Balashova N.V., Alekseeva М.V., Volkova L.Yu., Vodolazkaya A.N., Prokopenko E.V. Fetal programming as a trend in modern medicine: Magnesium deficiency is the focus. Medical alphabet. 2023; (29): 8-14 (in Russian). https://dx.doi.org/10.33667/2078-5631-2023-29-8-14].
- Auwercx J., Rybarczyk P., Kischel P., Dhennin-Duthille I., Chatelain D., Sevestre H. et al. Mg2+ transporters in digestive cancers. Nutrients. 2021; 13(1): 210. https://dx.doi.org/10.3390/nu13010210
- Huang Y., Jin F., Funato Y., Xu Z., Zhu W., Wang J. et al. Structural basis for the Mg2+ recognition and regulation of the CorC Mg2+ transporter. Sci. Adv. 2021; 7(7): eabe6140. https://dx.doi.org/10.1126/sciadv.abe6140
- Тетруашвили Н.К., Громова О.А. Алгоритм диагностики и лечения дефицита магния у беременных. Акушерство и гинекология. 2021; 3 (Прил.): 3-8. [Tetruashvili N.K., Gromova O.A. Algorithm for the diagnosis and treatment of magnesium deficiency in pregnant women. Obstetrics and Gynecology. 2021; 3(Suppl.): 3-8 (in Russian)].
- Дижевская Е.В. Обмен научными данными и экспертными мнениями по фармакотерапии в течение беременности: традиционные и современные подходы. III Международный экспертный совет по проблемам дефицита магния в акушерстве и гинекологии. Акушерство, гинекология и репродукция. 2015; 9(4): 93-101. https://dx.doi.org/10.17749/2070-4968.2015.9.4.093-101 [Dizhevskaya E.V. Exchange of scientific data and expert opinions on pharmacotherapy during pregnancy: traditional and modern approaches. III International Expert Council on Magnesium Deficiency in Obstetrics and Gynecology. Obstetrics, Gynecology and Reproduction. 2015; 9(4): 93-101 (in Russian). https://dx.doi.org/10.17749/2070-4968.2015.9.4.093-101].
Received 29.04.2026
Accepted 19.06.2026
About the Authors
Karina N. Mingareeva, PhD, Associate Professor at the Department of Obstetrics and Gynecology No. 2, Bashkir State Medical University, Ministry of Health of Russia, 450008, Russia, Republic of Bashkortostan, Ufa, Lenin str., 3, +7(917)37-15-999, mkn1805@mail.ru, https://orcid.org/0000-0001-9125-2614Alfiya G. Yashchuk, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology No. 2, Bashkir State Medical University, Ministry of Health of Russia, 450008, Russia, Republic of Bashkortostan, Ufa, Lenin str., 3, +7(917)343-17-15, alfiya_galimovna@mail.ru, https://orcid.org/0000-0003-2645-1662
Kseniya N. Yaschuk, Teaching Assistant at the Department of Pediatrics, Bashkir State Medical University, Ministry of Health of Russia, 450008, Russia, Republic of Bashkortostan, Ufa, Lenin str., 3, +7(937)366-38-22, https://orcid.org/0000-0002-8550-910X
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