The capabilities of 3D neurosonography in assessing the postnatal formation of the cerebral cortex in very preterm infants
Objective. To determine the stages of formation of the cerebral cortex and the terms of initial echographic visualization of its furrows in very preterm infants to reach a post-conceptual age of 40 weeks, by applying 3D neurosonography.Chugunova L.A., Narogan M.V., Ryumina I.I., Kirtbaya A.R., Gus A.I.
Material and methods. Archival 3D files of weekly brain scans from 39 very preterm infants were analyzed in the framework of a prospective study.
Results. In-depth analysis of serial sections by 3D neurosonography revealed a certain sequence of appearance of furrows in the image during the postnatal development of the cerebral cortex. The examination revealed no clear differences in the timing of initial echographic imaging of fissures in babies born from singleton and multiple pregnancies.
Conclusion. 3D neurosonography is a priority method for monitoring the postnatal development of the cerebral cortex in very preterm infants.
The results of this investigation can be used to assess the postnatal structural development of the cerebral cortex in very preterm infants, by using ultrasound imaging techniques.
Keywords
three-dimensional (3D NSG)
very preterm infant
cerebral cortex
Supplementary Materials
- Figure 1. Modes of 3D NSG А) - surface rendering; B) - tomographic ultrasound imaging; C) and D) – multiplanar view
- Figure 2. Images of the parieto-occipital and calcarine fissures at various post-conceptual age in very preterm infants identified with 3D NSG in the sagittal projection
- Figure 3. Stages of the cingulate and frontal fissures formation in very preterm infants according to the ultrasound (description in the text)
- Figure 4. Stages of insula and the superior temporal fissure formation in very preterm infants according to the 3D NSG
- Table 1. The timing of the initial detection of the cortex fissures in fetuses, newborns and very preterm infants according to ultrasound
References
1. Keshishyan E.S. Premature child: medical-social and psychological-pedagogical unresolved issues. Rossiyskiy vestnik perinatologii i pediatrii. 2015; 60(6): 5-9. (in Russian)
2. Sakharova E.S., Keshishyan E.S., Alyamovskaya G.A. Dynamics of morbidity and outcomes of development to 3 years of life in premature infants, observed in a specialized center. Rossiyskiy vestnik perinatologii i pediatrii. 2015; 60(3): 108-12. (in Russian)
3. Palchik A.B., Fedorova L.A., Ponyatishin A.E. Neurology of premature infants. Мoscow: MEDpress-inform; 2010. 342p. (in Russian)
4. Zavadenko N.N., Efimov M.S., Zavadenko A.N., Shchederkina I.O., Davydova L.A., Doronicheva М.М. Disorders of neuropsychic development in premature infants with low and extremely low birth weight. Pediatriya. Zhurnal im. G.N. Speranskogo. 2015; 94(5): 142-8. (in Russian)
5. Nosarti C., Murray R.M., Hack M., eds. Neurodevelopmental outcomes of preterm birth from childhood to adult life. Cambridge University Press; 2010. 277p.
6. Van Hus J.W., Potharst E.S., Jeukens-Visser M., Kok J.H., Van Wassenaer-Leemhuis A.G. Motor impairment in very preterm-born children: links with other developmental deficits at 5 years of age. Dev. Med. Child. Neurol. 2014; 56(6): 587-94.
7. van Dommelen P., Verkerk P.H., van Straaten H.L.; Dutch Neonatal Intensive Care Unit Neonatal Hearing Screening Working Group. Hearing loss by week of gestation and birth weight invery preterm neonates. J. Pediatr. 2015; 166(4): 840-3. e1.
8. Kurpershoek T., Potharst-Sirag E.S., Aarnoudse-Moens C.S., van Wassenaer-Leemhuis A.G. Minor neurological dysfunction in five year old very preterm children is associated with lower processing speed. Early Hum. Dev. 2016; 103: 55-60.
9. Slaughter L., Eliana Bonfante-Mejia A., Hintz S. R., Dvorchik I., Parikh N.A. Early conventional MRI for prediction of neurodevelopmental impairment in extremely-low-birth-weight infants. Neonatology. 2016; 110: 47-54.
10. Guarini A., Sansavini A., Fabbri C., Alessandroni R., Faldella G., Karmiloff-Smith A. Reconsidering the impact of preterm birth on language outcome. Early Hum. Dev. 2009; 85(10): 639-45.
11. Mulder H., Pitchford N.J., Hagger M.S., Marlow N. Development of executive function and attention in preterm children: A systematic review. Dev. Neuropsychol. 2009; 34(4): 393-421.
12. Ziborova M.I., Keshishyan E.S., Sakharova E.S. The role of pediatric post-neonatal monitoring of premature babies in optimizing their development, somatic health and social adaptation. Rossiyskiy vestnik perinatologii i pediatrii. 2015; 60(6): 10-4. (in Russian)
13. Ziborova M.I., Keshishyan E.S., Sakharova E.S. Long-term effect of prematurity on post-neonatal formation of neurohormonal regulation. Rossiyskiy vestnik perinatologii i pediatrii. 2016; 61(1): 27-31. (in Russian)
14. Gomella T.L., ed. Neonatology: management, procedures, on-call problems, diseases, and drugs. McGraw-Hill Education; 2013. 698p.
15. Rathbone R., Counsell S.J., Kapellou O., Dyet L., Kennea N., Hajnal J. et al. Perinatal cortical growth and childhood neurocognitive abilities. Neurology. 2011; 77(16): 1510-7.
16. Pistorius L.R., Stoutenbeek P., Groenendaal F., De Vries L., Manten G., Mulder E. et al. Grade and symmetry of normal fetal cortical development: a longitudinal twoand three-dimensional ultrasound study. Ultrasound Obstet. Gynecol. 2010; 36(6): 700-8.
17. Klebermass-Schrehof K., Moerth S., Vergesslich-Rothschild K., Fuiko R., Brandstetter S., Jilma B. et al. Regional cortical development in very low birth weight infants with normal neurodevelopmental outcome assessed by 3D-ultrasound. J. Perinatol. 2013; 33(7): 533-7.
18. Monteagudo A., Timor-Tritsch I.E. Development of fetal gyri, sulci and fissures: a transvaginal sonographic study. Ultrasound Obstet. Gynecol. 1997; 9(4): 222-8.
19. Cohen-Sacher B., Lerman-Sagie T., Lev D., Malinger G. Sonographic developmental milestones of the fetal cerebral cortex: a longitudinal study. Ultrasound Obstet. Gynecol. 2006; 27(5): 494-502.
20. Huang C.C., Yeh T.F. Assessment of gestational age in newborns by neurosonography. Early Hum. Dev. 1991; 25(3): 209-20.
21. Voevodin S.M., Ozerova O.E. Normal echographic anatomy of the brain in newborns of different gestational age. Akusherstvo i Ginekologiya/Obstetrics and gynecology. 1991; 6: 33-42. (in Russian)
22. Zubareva E.A., Ulezko E.A. Neurosonography in young children. Minsk: Paradox; 2004. 192p. (in Russian)
23. Levine D., Barnes P.D. Cortical maturation in normal and abnormal fetuses as assessed with prenatal MR imaging. Radiology. 1999; 210(3): 751-8.
24. Dubois J., Benders M., Borradori-Tolsa C., Cachia A. Primary cortical folding in the human newborn: an early marker of later functional development. Brain. 2008; 131(8): 2028-41.
Received 04.04.2017
Accepted 28.04.2017
About the Authors
Chugunova Liliyana Anatolievna, Ph.D., Senior researcher, Department of Functional and Ultrasound Diagnostics, Research Center of Obstetrics,Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: l_chugunova@oparina4.ru
Narogan Marina Viktorovna, MD, Ph.D. Department of pathology of newborns and premature infants, Research Center of Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia; Professor of the Department of Neonatology, I.M. Sechenov First Moscow State Medical University. 1
17997, Russia, Moscow, Ac. Oparina str. 4. E-mail: m_narogan@oparina4.ru
Ryumina Irina Ivanovna, MD, head of the department of pathology of newborns and premature infants, Research Center of Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia; Professor of the Department of Neonatology, I.M. Sechenov First Moscow State Medical University.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79037708048. E-mail: i_ryumina@oparina4.ru
Kirtbai Anna Revazievna, Ph.D., Head of Clinical Operations, Department of Intensive Care and Intensive Care of Newborns, Research Center of Obstetrics,
Gynecology and Perinatology, Ministry of Health of Russia; Associate Professor of the Department of Neonatology, I.M. Sechenov First Moscow State Medical University. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79166507802. E-mail: a_kirtbaya@oparina4.ru
Gus Alexander Iosifovich, MD, Professor, Head of the Department of Ultrasound and Functional Diagnostics of the Visual Diagnostics Department,
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381177. E-mail: a_gus@oparina4.ru
For citations: Chugunova L.A., Narogan M.V., Ryumina I.I.,
Kirtbaya A.R., Gus A.I. The capabilities of 3D neurosonography in assessing
the postnatal formation of the cerebral cortex in very preterm infants.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (7): 120-8. (in Russian)
http://dx.doi.org/10.18565/aig.2017.7.120-8
Similar Articles
