Possibilities of predicting the outcomes of assisted reproductive technology programs in patients with ovarian endometrioid cysts on the basis of the metabolic profile of follicular fluid
At present, the problem of restoring fertility in patients with ovarian endometrioid cysts is the focus of attention for physicians around the world. Despite intensive research, the search for biomarkers that affect the effectiveness of in vitro fertilization programs in this patient group is not progressing well enough. Follicular fluid is a biological medium that has a direct impact on oocyte growth and maturation, and subsequently on the process of fertilization. The search for biomarkers that can be further used as prognostic factors for embryo development and outcomes of in vitro fertilization programs is an extremely important area. This literature review presents data on changes in the metabolomic profile of follicular fluid in patients with ovarian endometrioid cysts and discusses the current potentials of metabolomics in order to enhance the efficiency of infertility treatment and to optimize the embryological stage in women with endometriomas.Nikolenko I.G., Smolnikova V.Yu., Chagovets V.V.
Conclusion. Based on the findings, further investigations to study the metabolomic profile of follicular fluid is relevant and may lead to the development of new prognostic strategies, as well as to the elaboration of algorithms for the management of patients with this pathology in the assisted reproductive technology programs.
Keywords
infertility
endometriosis
ovarian endometrioid cysts
in vitro fertilization
oocyte
metabolome
follicular fluid
embryo implantation
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Received 15.04.2020
Accepted 12.10.2020
About the Authors
Inna G. Nikolenko, Postdoc of IVF Department, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russia.Tel.: +7(925)537-95-03. E-mail: nikolenkoinna@mail.ru. 117997, Russia, Moscow, Academica Oparina str., 4.
Veronika Yu. Smolnikova, PhD, leading researcher, Department of Assistive Technologies in Infertility Treatment, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
Тел.: +7(495)438-49-77. E-mail: veronika.smolnikova@mail.ru. 117997, Russia, Moscow, Academica Oparina str., 4.
Vitaliy V. Chagovets, Ph.D. in Physical and Mathematical Sciences, Senior researcher of the Laboratory of Proteomics and Metobolomics of the Human Reproduction,
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
Tel.: +7(916)919-14-66. E-mail: vvchagovets@gmail.com. 117997, Russia, Moscow, Academica Oparina str., 4.
For citation: Nikolenko I.G., Smolnikova V.Yu., Chagovets V.V. Possibilities of predicting the outcomes of assisted reproductive technology programs in patients with ovarian endometrioid cysts on the basis of the metabolic profile of follicular fluid.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 11: 44-48 (in Russian).
https://dx.doi.org/10.18565/aig.2020.11.44-48
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