Impact of anemia in pregnant women on the health status of their premature babies with very low and extremely low birth weight
Sharafutdinova D.R., Balashova E.N., Ionov O.V., Kirtbaya A.R., Golubtsova Yu.M., Pavlovich S.V.
Objective. To evaluate the impact of anemia during pregnancy in women on the health status of their premature newborns with very low and extremely low birth weight (VLBW and ELBW).
Subjects and methods. A one-stage comparative study was conducted at the V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology in January 2017 to November 2018. It enrolled 105 women and their premature neonatal infants with VLBW and ELBW, who were divided into 2 groups: 1) VLBW and ELBW babies born to women who had anemia of varying severity during pregnancy (n = 38) and 2) those born to women without anemia during pregnancy (n = 67).
Results. The examined groups of newborns showed statistical differences in gestational age that was 1 week less in Group 1 than in Group 2 (p = 0.004). There were no statistically significant differences in birth weight and height; data on 1 and 5 minute Apgar scores were not obtained in both groups. The death rates were higher in Group 1 than in Group 2; however, there were no statistically significant differences (p = 0.093). The frequency of early transfusions of red blood cell and blood components (within the first week of life) was significantly higher in Group 1 babies (p = 0.01). The relative rate of bronchopulmonary dysplasia was higher in Group 1 than in Group 2; there was a tendency towards statistical significance of differences (p = 0.06). Comparison of outcomes, such as congenital infection, intraventricular hemorrhage, periventricular leukomalacia, retinopathy of prematurity, and other diseases, revealed no significant differences in Groups 1 and 2.
Conclusion. Anemia during pregnancy in women who have given birth to VLBW and ELBW babies is associated with a lower gestational age and with the course of the neonatal period of premature infants, in particular, those with a more frequent need for early blood transfusions.
Keywords
anemia in pregnancy
premature neonatal infants
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Received 22.02.2019
Accepted 19.04.2019
About the Authors
Diana R. Sharafutdinova, graduate student of the Neonatal Intensive Care Unit named by professor Antonov A.G. of the Institute of neonatology and pediatrics National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation.Phone: +7 (495) 438-22-77. E-mail: dikarush@gmail.com ID orcid.org/ 0000-0001-9626-5481 117997, Russia, Moscow, Oparina street, 4.
Ekaterina N. Balashova, PhD, Chief of clinicians of the Neonatal Intensive Care Unit named by professor Antonov A.G. of the Institute of neonatology and pediatrics National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, Associate Professor of Neonatology Department National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation Phone: +7(495) 438-2277. E-mail: e_balashova@oparina4.ru
ID orcid.org/0000-0002-3741-0770 117997, Russia, Moscow, Oparina street, 4.
Аnna R. Kirtbaya, PhD, Chief of clinicians of the Neonatal Intensive Care Unit named by professor Antonov A.G. of the Institute of neonatology and pediatrics National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, gynecology and perinatology Ministry of Health of the Russian Federation, Associate Professor of Neonatology Department at the Faculty of Pediatrics of I.M. Sechenov First Moscow State Medical University. Phone: +7 (495) 438-2277; E-mail: a_kirtbaya@oparina4.ru ID orcid.org/0000-0002-7628-8157
117997, Russia, Moscow, Oparina street, 4.
Oleg V. Ionov, Ph.D., Head of the of the Neonatal Intensive Care Unit named by professor Antonov A.G. of the Institute of neonatology and pediatrics National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, Associate Professor of Neonatology Department at the Faculty of Pediatrics of I.M. Sechenov First Moscow State Medical University. Phone: +7 (495) 438-22-77. E-mail: o_ionov@oparina4.ru
ID orcid.org/0000-0002-4153-133X 117997 Russia, Moscow, Oparina street, 4.
Julia M. Golubtsova, Ph.D., associate professor of the department, manager educational part of the Department of Neonatology Pediatric Faculty Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University) neonatologist scientific advisory pediatric unit pediatrics National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation; +7 (916)734-10-58; yugolubtsova@yandex.ru
119435 Russia, Moscow, st. Bolshaya Pirogovskaya, d.2, p.4, room. 106; 117997 Russia, Moscow, Oparina street, 4.
Stanislav V. Pavlovich, Ph.D., academic secretary, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, Associate Professor of the Department of Obstetrics, Gynecology, perinatology and reproductology I.M. Sechenov
First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenov University).
Phone: (495) 438-20-88. E-mail: s_pavlovich@oparina4.ru ID orcid.org/0000-0002-1313-7079 117997 Russia, Moscow, Oparina street, 4.
For citation: Sharafutdinova D.R., Balashova E.N., Ionov O.V., Kirtbaya A.R., Golubtsova Yu.M., Pavlovich S.V. Impact of anemia in pregnant women on the health status of their premature babies with very low and extremely low birth weight.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 9:111-7.(In Russian)
https://dx.doi.org/10.18565/aig.2019.9.111-117
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