Current trends in the management of bacterial vaginosis

Apolikhina I.A., Afendieva Z.N.

1) V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia
Despite the fact that ICD-10 does not encode bacterial vaginosis (BV) as a separate disease; today it is an unresolved reproductive health problem in women and along with other vulvovaginal infections remains one of the most common reasons for visiting a gynecologist. The paper reviews the data available in world and Russian literature on the efficacy and safety of dequalinium chloride used to treat BV. It discusses the mechanisms for the emergence of resistance of microorganisms to standard therapy regimens and the benefits of alternative treatments. The paper provides the 2018 clinical recommendations of the International Union Against Sexually Transmitted Infections (IUSTI)/World Health Organization (WHO) for the management of patients with pathological vaginal discharge. By taking into account a wide range of actions, evidence-based therapy effective against anaerobic and aerobic bacteria, fungi, and protozoa, the lack of resistance in microorganisms, and the possibility of use in all trimesters of pregnancy and during lactation, dequalinium chloride can be recommended as the drug of choice for the therapy of bacterial vaginosis caused by pathogens, including A. vaginae resistant to standard treatment regimens.


bacterial vaginosis
vulvovaginal infections
antibiotic resistance
dequalinium chloride


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Received 11.11.2019

Accepted 29.11.2010

About the Authors

Inna A. Apolikhina, MD, Head of the Department of Aesthetic Gynecology and Rehabilitation of National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. Professor of the Depertment of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Professional Education of the I.M. Sechenov First MSMU of Ministry of Health of Russia (Sechenov University). E-mail:
117997, Russia, Moscow, Ac. Oparina str. 4.
Zulphiya N. Efendieva, postgraduate student at the Depertment of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Professional Education
of the I.M. Sechenov First MSMU of Ministry of Health of Russia (Sechenov University). E-mail:
Address: 119991, Russia, Moscow, ul. Bolshaya Pirogovskaya, 2/ 4.

For citation: Apolikhina I.A., Efendieva Z.N. Current trends in the management of bacterial vaginosis.
Akusherstvo i Ginekologiya / Obstetrics and gynecology. 2019; 12: 193-6.(In Russian).

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