Role of HOX genes associated with infertility in female reproductive system diseases
Objective. To carry out a systematic analysis of the data available in the current literature on the role of HOX genes in realizing the reproductive potential in women.Knyazeva E.A., Kalinina E.A., Bystritsky A.A., Alieva K.U., Bairamova G.R.
Material and methods. The review includes the data of foreign and Russian articles published in the past 10 years and found in Pubmed on this topic. The search depth was 7 years.
Results. The paper gives data on the impaired work of individual genes of the HOX gene family in a number of reproductive system diseases: endometriosis, uterine fibroids, chronic endometritis, etc. It highlights that the НОХА10 and НОХА11 genes are important in the regulation of endometrial receptivity and describes that there may be a relationship between these genes and infertility.
Conclusion. The results of the performed investigations confirm the prospect and urgency of a study of the role of the НОХА10 and НОХА11 genes in the etiology of infertility, as well as methods for influencing the expression of the above genes.
Keywords
HOX genes
НОХА10
НОХА11
infertility
endometrial receptivity
implantation window
DNA methylation
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Received 10.01.2017
Accepted 17.02.2017
About the Authors
Knyazeva Ekaterina Andreevna, post-graduate student of the Department of Auxiliary Technologies in Infertility Treatment, Research Center of Obstetrics, Gynecology,and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954382501. E-mail: dr.knyazeva.ea@gmail.com
Kalinina Elena Anatolievna, MD, associate professor, head of the department of assistive technologies in infertility treatment, Research Center of Obstetrics, Gynecology,
and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381341. E-mail: e_kalinina@oparina4.ru
Andrey A. Bystritsky, Cand. Sc. (Biology), Leading Researcher of the Laboratory of Molecular Genetic Methods, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381341. E-mail: andrey.bystritskiy@yandex.ru
Alieva Kamila Ullubievna, Ph.D., doctor of the department of auxiliary technologies in infertility treatment, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381341. E-mail: kaya79@mail.ru
Bayramova Gyuldana Raufovna, MD, head of the department. on the clinical work of the scientific and polyclinic department, Research Center of Obstetrics, Gynecology,
and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79099947700. E-mail: bayramova@mail.ru
For citations: Knyazeva E.A., Kalinina E.A., Bystritsky A.A., Alieva K.U., Bairamova G.R. Role of HOX genes associated with infertility in female reproductive system diseases. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (11): 16-22. (in Russian)
https://dx.doi.org/10.18565/aig.2017.11.16-22
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