Iron deficiency states during pregnancy: prevention and treatment

Tyutyunnik V.L., Kan N.E., Khachatryan L.V., Baranov I.I.

1) Perinatal Center, European Medical Center, Moscow, Russia; 2) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia; 3) I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia
Objective. To investigate the efficacy of prolonged-release ferrous sulphate (Tardyferon) in the prevention and treatment of iron deficiency states during pregnancy.
Subjects and methods. A total of 159 singleton pregnant women with mild and moderate iron deficiency anemia (IDA) were followed up. All the patients were treated with a prolonged-release drug containing ferrous sulphate 247.325 mg, calculated in terms of iron 80 mg (Tardyferon).
Results. The main blood count indicators were lower in pregnant women treated with Tardyferon. After a treatment cycle, complaints of shortness of breath and weakness disappeared in all the patients. Moreover, a clinical effect was achieved after 2 weeks of therapy whereas hematological parameters became normal 4 weeks later. In addition, all the patients continued treatment with prophylactic doses during a month after delivery, as recommended in the instructions for Tardyferon use.
Conclusion. Prolonged-release ferrous sulphate (Tardyferon) is highly effective in preventing and treating IDA in pregnant women, leading to statistically significant normalization of ferrokinetic parameters and blood counts, improving the general condition of patients, and reducing obstetric and neonatal complications.


iron deficiency states
iron deficiency anemia


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Received 20.05.2020

Accepted 27.05.2020

About the Authors

Victor L. Tyutyunnik, PhD, MD, deputy head doctor of the Perinatal Center European Medical Center. Tel.: +7(903)969-50-41. E-mail:
Researcher ID B-2364-2015. ORCID ID 0000-0002-5830-5099.
125040, Moscow, Pravda str. 15/1, Russia.
Natalia E. Kan, PhD, MD, head doctor of the Perinatal Center European Medical Center; Professor of the Department of Obstetrics and Gynecology of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia.
Tel.: +7(926)220-86-55. E-mail:
Researcher ID B-2370-2015. ORCID ID 0000-0001-5087-5946.
125040, Moscow, Pravda str. 15/1, Russia; 117997, Moscow, Ac. Oparina str. 4, Russia.
Lia V. Khachtryan, student of Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University). Tel.: +7(963)977-88-94. E-mail:
119992, Moscow, Trubetskaya str. 8-2, Russia.
Igor I. Baranov, MD, professor, head of the organizational and methodological department of the scientific and organizational support service of the Obstetrics and Gynecology of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia, Scientific Secretary of the Russian Society of Obstetricians and Gynecologists. Tel.: +7(495)438-94-92. E-mail: ORCID ID: 0000-0002-9813-2823.
117997, Moscow, Ac. Oparina str. 4, Russia.

For reference: Tyutyunnik V.L., Kan N.E., Khachatryan L.V., Baranov I.I. Iron deficiency states during pregnancy: prevention and treatment. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 6: 89-96 (in Russian).

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