The features of the course and outcome of pregnancy in a patient with
Background: A decreased glomerular filtration rate in patients with chronic kidney diseases with the development of renal failure leads not only to infertility and amenorrhea, but also to a high risk for the unfavorable course and outcomes of pregnancy. More than half of babies whose mothers require renal replacement therapy are born prematurely and are underweight. An increasing number of hemodialysis hours minimize the risk of antenatal fetal death because of the improved monitoring of urea nitrogen clearance.Strizhakov A.N., Ignatko I.V., Bogomazova I.M., Timokhina E.V., Belousova V.S., Muravina E.L., Samoylova Yu.A., Rasskazova T.V.
Case report: This clinical observation gives the history data of a 34-year- old patient with the absence of both kidneys after bilateral nephrectomy as part of a one-stage donor kidney transplantation and then transplantatectomy for end-stage renal failure in the presence of rapidly progressive glomerulonephritis and allograft rejection, as well as the features of the course of her pregnancy and perinatal outcomes. The patient received renal replacement therapy for a year before and throughout the pregnancy.
Conclusion: Timely correction of hemodialysis parameters and metabolic disorders could prolong pregnancy to the period that was prognostically favorable from the perinatal points of view.
Keywords
renal replacement therapy
absence of both kidneys
renal failure
program hemodialysis
chronic kidney diseases
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Received 01.09.2021
Accepted 17.11.2021
About the Authors
Alexander N. Strizhakov, Dr. Med. Sci., Academician of the RAS, Professor, Head of the Department of Obstetrics, Gynecology and Perinatology of the N.V. SklifosovskyInstitute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University),
+7(499)782-30-45, kafedra-agp@mail.ru, 119991, Russian Federation, Moscow, Trubetskaya str., 8-2.
Irina V. Ignatko, Dr. Med. Sci., Corresponding Member of the RAS, Professor of the RAS, Professor, Professor of the Department of Obstetrics, Gynecology and Perinatology
of the N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
(Sechenov University), +7(499)782-30-45, kafedra-agp@mail.ru, 119991, Russian Federation, Moscow, Trubetskaya str., 8-2.
Irina M. Bogomazova, PhD., Associate Professor of the Department of Obstetrics, Gynecology and Perinatology of the N.V. Sklifosovsky Institute of Clinical Medicine,
I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University),
+7(926)305-04-03, Irinka.bogomazova@mail.ru, https://orcid.org/0000-0003-1156-7726, 119991, Russian Federation, Moscow, Trubetskaya str., 8-2.
Elena V. Timokhina, Dr. Med. Sci., Associate Professor, Professor of the Department of Obstetrics, Gynecology and Perinatology of the N.V. Sklifosovsky Institute of Clinical
Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University),
+7(499)782-30-45, kafedra-agp@mail.ru, 119991, Russian Federation, Moscow, Trubetskaya str., 8-2.
Vera S. Belousova, PhD., Associate Professor, Associate Professor of the Department of Obstetrics, Gynecology and Perinatology of the N.V. Sklifosovsky Institute of Clinical
Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), +7(499)782-30-45,
kafedra-agp@mail.ru, 119991, Russian Federation, Moscow, Trubetskaya str., 8-2.
Elena L. Muravina, PhD., Deputy Chief Physician for Obstetrics and Gynecology, S.S. Yudin City Clinical Hospital of Moscow Healthcare Department, +7(499)782-30-64,
gkb-yudina@zdrav.mos.ru, 115446, Russian Federation, Moscow, Kolomensky proezd, 4.
Yulia A. Samoylova, PhD., Head of the Department of Pregnancy Pathology No. 1 of the maternity hospital, S.S. Yudin City Clinical Hospital of Moscow Healthcare
Department, +7(499)782-30-64, gkb-yudina@zdrav.mos.ru, 115446, Russian Federation, Moscow, Kolomensky proezd, 4.
Tatyana V. Rasskazova, obstetrician-gynecologist of the Department of Pregnancy Pathology No. 1 of the maternity hospital, S.S. Yudin City Clinical Hospital of Moscow
Healthcare Department, +7(499)782-30-64, gkb-yudina@zdrav.mos.ru, 115446, Russian Federation, Moscow, Kolomensky proezd, 4.
Corresponding author: Irina M. Bogomazova, Irinka.bogomazova@mail.ru
Authors’ contributions: Strizhakov A.N., Ignatko I.V., Bogomazova I.M., Timokhina E.V., Belousova V.S. - concept and design of the investigation; Bogomazova I.M., Muravina E.L., Samoylova Yu.A., Rasskazova T.V. - material collection and processing; Ignatko I.V., Bogomazova I.M. - statistical data processing; Bogomazova I.M. - writing the text; Strizhakov A.N., Ignatko I.V., Timokhina E.V., Belousova V.S. - editing.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The authors declare that there is no funding.
Patient Consent for Publication: The patient provided informed consent for the publication of her data.
For citation: Strizhakov A.N., Ignatko I.V., Bogomazova I.M., Timokhina E.V., Belousova V.S., Muravina E.L., Samoylova Yu.A., Rasskazova T.V. The features of the course and outcome of pregnancy in a patient with the absence of both kidneys. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 1:148-152 (in Russian)
https://dx.doi.org/10.18565/aig.2022.1.148-152
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