Immune antiviral drug therapy in patients with HPV-associated cervical intraepithelial neoplasia grade I
Objective. To improve quality of life in patients with cervical intraepithelial neoplasia grade I (CIN I) associated with human papillomavirus ((HPV) infection due to a medical treatment without destructive intervention.Epifanova O.V., Vinogradova O.P., Andreeva N.A.
Subjects and methods. The investigation of relevance to specialties was conducted at the Department of Obstetrics and Gynecology, Penza Institute for Postgraduate Training for Physicians. Examinations were made in 86 reproductive-aged women with cervical pathology and high-risk HPV (hr-HPV) who had attended outpatient clinics in Saransk.
Results. The investigation established the patterns of hr-HPV prevalence in women with CIN I, as well as its relationship to the functioning of the immune system. Dysregulation that was manifested in the predominance of anti-inflammatory cytokines over pro-inflammatory ones increased the probability of virus persistence in the body, which is likely to contribute to the development of neoplastic processes and more advanced intraepithelial lesions.
Conclusion. The data obtained from the conducted studies allow optimization of the management of patients with HPV-induced CIN I without destructive therapies.
Keywords
cervical intraepithelial neoplasia
human papillomavirus
cervical cancer
polymerase chain reaction
genotyping
high risk for cancer
viral load
gamma-interferon
allokin-alpha
interleukin-18
tumor necrosis factor-alpha
Alloferon
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Received 27.11.2019
Accepted 29.11.2019
About the Authors
Olga V. Epifanova, Assistant of the Department of Obstetrics and Gynecology, Penza Institute for the Advancement of Doctors - a branch of the Russian Medical Academyof Postgraduate Education of the Russian Ministry of Health.
Address: 440060 Russia, Penza, st. Stasova, 8A.
Olga P. Vinogradova, MD, professor of the Department of Obstetrics and Gynecology, Penza Institute for the Advancement of Doctors - a branch of the Russian Medical Academy of Postgraduate Education of the Russian Ministry of Health.
Address: 440060 Russia, Penza, st. Stasova, 8A.
Natalya A. Andreeva, candidate of medical sciences, associate professor of the Department of Obstetrics and Gynecology, National Research Mordovian State University named after N.P. Ogaryova.
Address: 430005 Russia, Saransk, Republic of Mordovia, ul. Bolshevik, d. 68.
For citation: Epifanova O.V., Vinogradova O.P., Andreeva N.A. Immune antiviral drug therapy in patients with HPV-associated cervical intraepithelial neoplasia grade I.
Akusherstvo i Ginekologiya/Obstetrics and gynecology. 2020;3: 174-80.(In Russian).
https://dx.doi.org/10.18565/aig.2020.3.174-180
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