Immune antiviral drug therapy in patients with HPV-associated cervical intraepithelial neoplasia grade I

Epifanova O.V., Vinogradova O.P., Andreeva N.A.

1) Penza Institute for Postgraduate Training of Physicians, Branch, Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia, Penza, Russia; 2) N.P. Ogarev Mordovia State University, Saransk, Russia
Objective. To improve quality of life in patients with cervical intraepithelial neoplasia grade I (CIN I) associated with human papillomavirus ((HPV) infection due to a medical treatment without destructive intervention.
Subjects and methods. The investigation of relevance to specialties was conducted at the Department of Obstetrics and Gynecology, Penza Institute for Postgraduate Training for Physicians. Examinations were made in 86 reproductive-aged women with cervical pathology and high-risk HPV (hr-HPV) who had attended outpatient clinics in Saransk.
Results. The investigation established the patterns of hr-HPV prevalence in women with CIN I, as well as its relationship to the functioning of the immune system. Dysregulation that was manifested in the predominance of anti-inflammatory cytokines over pro-inflammatory ones increased the probability of virus persistence in the body, which is likely to contribute to the development of neoplastic processes and more advanced intraepithelial lesions.
Conclusion. The data obtained from the conducted studies allow optimization of the management of patients with HPV-induced CIN I without destructive therapies.

Keywords

cervical intraepithelial neoplasia
human papillomavirus
cervical cancer
polymerase chain reaction
genotyping
high risk for cancer
viral load
gamma-interferon
allokin-alpha
interleukin-18
tumor necrosis factor-alpha
Alloferon

References

  1. Каприн А.Д., Старинский В.В., Петрова Г.В., ред. Злокачественные новообразования в России в 2017 году (заболеваемость и смертность). М., 2018. 250 с. [Kaprin A.D., Starinsky V.V., Petrova G.V., ed. Malignant neoplasms in Russia in 2017 (morbidity and mortality). Moscow, 2018. 250 p. (in Russian)].
  2. Середа Н.Б., Маркелова Е.В., Спорыхина Т.Д. и др. Патогенетическая роль вируса папилломы человека в патологии шейки матки. Российский аллергологический журнал. 2010; 1: 160–162. [Sereda N.B., Markelova E.V., Sporykhina T.D. et al. Pathogenetic role of human papillomavirus in the pathology of the cervix. Russian Allergy Journal. 2010; 1: 160–162. (in Russian)].
  3. Бебнева Т.Н., Муйжнек Е.Л., Роговская С.И., Киселев В.И., Ашрафян Л.А., Хамошина М.Б. Патогенетическое лечение неопластических процессов шейки матки: новые подходы. Доктор.Ру. 2016; 120(3): 9–14. [Bebneva T.N., Muizhnek E.L., Rogovskaya S.I., Kiselev V.I., Ashrafyan L.A., Khamoshina M.B. Cervical Neoplasia: New Approaches to Pathogenesis-Oriented Treatment. Doctor.Ru.. 2016; 120(3): 9–14. (in Russian)]
  4. Campos A.C., Murta E.F., Michelin M.A. et al. Evaluation of cytokines in endocervical secretion and vaginal pH from women with bacterial vaginosis or human papillomavirus. ISRN Obstet Gynecol. 2012; 2012: 342075. doi: 10.5402/2012/342075.
  5. Chan C.J., Smyth M.J., Martinet L. Molecular mechanisms of natural killer cell activation in response to cellular stress. Cell Death Differ.2014; 21(1): 5–14. doi: 10.1038/cdd.2013.26
  6. Origoni М., Salvatore S., Perino A., et al. Cervical Intraepithelial Neoplasia (CIN) in pregnancy: the state of the art. Eur. Rev. Med. Pharmacol. Sci. 2014; 18(6): 851–60. PMID: 24706310
  7. Schneider W.M., Chevillotte M.D., Rice C.M. Interferon-stimulated genes: a complex web of host defenses. Annu Rev Immunol. 2014; (32): 513–45. doi: 10.1146/annurev-immunol-032713-120231
  8. Ванденбуш К.Дж., Али С.З., Розенталь Д.Л.., Ванг Р. Цитологическое исследование цервикальных мазков. Атлас. М.: ГЭОТАР-Медиа, 2018. 206 с. [Vandenbush K.J., Ali S.Z., Rosenthal D.L., Wang R. Cytological examination of cervical smears. Atlas. M.: GEOTAR-Media, 2018. 206 p. (in Russian)].
  9. Белокриницкая Т.Е., Фролова Н.И., Туранова О.В., Шемякина К.Н., Плетнева В.А. и др. Результативность и приемлемость обследования на вирус папилломы человека при самостоятельном и врачебном заборе вагинального отделяемого. Акушерство и гинекология. 2017; 2: 97–105. [Belokrinitskaya T.E., Frolova N.I., Turanova O.V., Shemyakina K.N., Pletneva V.A., et al. The effectiveness and acceptability of screening for human papillomavirus in self- and medical sampling of vaginal discharge. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; 2: 97–105 (in Russian)] http://dx.doi.org/10.18565/aig.2017.2.97–105
  10. Keppler D., Lin A. Cervical cancer: methods and protocols. NY.: Humana Press, 2015; 1249: XIV, 413. doi: 10.1007/978-1-4939-2013-6
  11. Полонская Н.Ю., Юрасова И.В. Цитологическое исследование цервикальных мазков. Пап-тест. М.: ГЭОТАР-Медиа, 2018. 168 с. [Polonskaya N.Yu., Yurasova I.V. Cytological examination of cervical smears. Dad test. M.: GEOTAR-Media, 2018. 168 s. (in Russian)].
  12. Куценко И.И., Боровиков И.О., Дехтяренко Ю.В., Булгакова В.П. Комплексная терапия рецидивирующего генитального герпеса у женщин. Вестник РУДН. Серия: медицина. 2012; 5: 334–41. [Kutsenko I.I., Borovikov I.O., Dehtjarenko J.V., Bulgakova V.P. Complex therapy recidive genital herpes of the women. RUDN Journal of Medicine. 2012; 5: 334–41. (in Russian)].
  13. Шульженко А.Е., Зуйкова И.Н. Персистирующая папилломавирусная инфекция: цитокиновый дисбаланс и подходы к терапии. Эффективная фармакотерапия. Акушерство и гинекология. 2013; 2: 54–60. [Shulzhenko A.E., Zuikova I.N. Persistent human papillomavirus infection: a cytokine imbalance and approaches to therapy. Effective pharmacotherapy. Obstetrics and gynecology. 2013; 2: 54–60. (in Russian)].
  14. Kuczer M., Dziubasik K., Midak-Siewirska A., Zahorska R., Łuczak M., Konopińska D. Studies of insect peptides alloferon, Any-GS and their analogues. Synthesis and antiherpes activity. J Pept Sci. 2010; 16(4): 186–9. doi: https://doi.org/10.1002/psc.1219
  15. Annual Report «Evaluation of the Effect of Alloferon In vivo and In Vitro», Seoul National University College of Medicine, 2008.

Received 27.11.2019

Accepted 29.11.2019

About the Authors

Olga V. Epifanova, Assistant of the Department of Obstetrics and Gynecology, Penza Institute for the Advancement of Doctors - a branch of the Russian Medical Academy
of Postgraduate Education of the Russian Ministry of Health.
Address: 440060 Russia, Penza, st. Stasova, 8A.
Olga P. Vinogradova, MD, professor of the Department of Obstetrics and Gynecology, Penza Institute for the Advancement of Doctors - a branch of the Russian Medical Academy of Postgraduate Education of the Russian Ministry of Health.
Address: 440060 Russia, Penza, st. Stasova, 8A.
Natalya A. Andreeva, candidate of medical sciences, associate professor of the Department of Obstetrics and Gynecology, National Research Mordovian State University named after N.P. Ogaryova.
Address: 430005 Russia, Saransk, Republic of Mordovia, ul. Bolshevik, d. 68.

For citation: Epifanova O.V., Vinogradova O.P., Andreeva N.A. Immune antiviral drug therapy in patients with HPV-associated cervical intraepithelial neoplasia grade I.
Akusherstvo i Ginekologiya/Obstetrics and gynecology. 2020;3: 174-80.(In Russian).
https://dx.doi.org/10.18565/aig.2020.3.174-180

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