Experience in preparing obese patients for infertility treatment

Zhuk T.V., Yavorskaya S.D., Vostrikov V.V., Nagaitsev V.M., Kotov A.O.

1) Altai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia; 2) Siberian Institute of Human Reproduction and Genetics, Barnaul, Russia
Objective. To study whether Reduxin Forte can be used in obese patients planning IVF.
Subjects and methods. Thirty women with grade 1 obesity were examined and treated. Along with physical exercises and diet, Reduxin Forte (sibutramine 10-15 mg/day + metformin 850 mg/day) was used in the patients for 3 months. Anthropometric and carbohydrate metabolic parameters and the oxidative stress marker 8-OH-deoxyguanosine (8-OHdG) were estimated before and after treatment.
Results. Prior to and following treatment, there were reductions in weight by 10.8% (90.597±5.79 vs. 80.773±5.58 kg; p = 0.017), BMI (33.324±1.53 vs. 29.719±1.55; p = 0.002), waist (96.733±3.92 vs. 89.133±3.91 cm; p = 0.008) and hip (114.067±4.40 vs. 107.733±3.54 cm; p = 0.028) circumferences. It should be emphasized that there were also decreases in insulin levels (15.271±2.67 vs. 10.049±1.72 μU/ml; p = 0.002), HOMA index (3.673±0.67 vs. 2.28±0.41; p < 0.001), and the levels of the oxidative stress marker 8-OHdG (0.361±0.082 vs. 0.240±0.029 ng/ml; p = 0.007).
Conclusion. Three-month use of Reduxin Forte in patients with grade I obesity, who planned IVF, improved anthropometric parameters, normalized carbohydrate metabolism, and decreased 8-OHdG levels. Pregnancy after VF and in a natural cycle occurred in 8/18 (44.4%) and 8/26 (30.7%) of women, respectively.

Keywords

infertility
IVF
oxidative stress
antioxidant system

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Received 05.02.2020

Accepted 07.02.2020

About the Authors

Tamara V. Zhuk, Department of Obstetrics and Gynecology with a course DPO FSBEI HE AGMU Russian Ministry of Health.
656038, Russian Federation, Altai Territory, Barnaul, Lenin Avenue, d. 40.
Svetlana D. Yavorskaya, MD, Associate Professor, Professor, Altai State Medical University, Ministry of Health of the Russian Federation, Barnaul.
656038, Russian Federation, Altai Territory, Barnaul, Lenin Avenue, d. 40.
Vyacheslav V. Vostrikov, candidate of medical sciences, obstetrician-gynecologist, assistant at the Department of Obstetrics and Gynecology No. 1 of Altai State Medical University; ch. Doctor of the Siberian Institute of Reproduction and Human Genetics. Tel .: +7 (3852) 50-10-88. E-mail: wkoctar@mail.ru
656006, Russian Federation, Barnaul, Malakhova St., 123, room N6.
Vladimir M. Nagaytsev, candidate of medical sciences, doctor of clinical laboratory diagnostics, laboratory geneticist, doctor embryologist, head of the laboratory of the Siberian Institute of Human Reproduction and Genetics. Tel .: +7 (3852) 50-10-88. E-mail: ivfaltai@mail.ru
656006, Russian Federation, Barnaul, Malakhova St., 123, room N6.
Alexey O. Kotov, doctor of clinical laboratory diagnostics, deputy head of the laboratory of the Siberian Institute of Human Reproduction and Genetics.
Tel .: +7 (3852) 50-10-77. E-mail: 501077@bk.ru
656006, Russian Federation, Barnaul, Malakhova St., 123, room N6.

For citation: Zhuk T.V., Yavorskaya S.D., Vostrikov V.V., Nagaitsev V.M., Kotov A.O. Experience in preparing obese patients for infertility treatment.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 3: 191-96. (In Russian).
https://dx.doi.org/10.18565/aig.2020.3.191-196

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