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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2022№8
Gut and genital microbiota in...

Gut and genital microbiota in endometriosis

DOI
https://dx.doi.org/10.18565/aig.2022.8.22-29

Chernukha G.E., Pronina V.A., Priputnevich T.V.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia
Endometriosis is a hormone-dependent disease associated with the development of chronic inflammation. The prevalence of this disease does not tend to decrease. The absence of a unified generally accepted theory on the origin of endometriosis is the basis for continuing investigations aimed at searching for possible mechanisms for the development of the disease in order to improve the principles of diagnosis and therapy of this pathological process. One of the theories of endometriosis is the hypothesis of bacterial infection, in which the bacterial endotoxin lipopolysaccharide is supposed to be a triggering factor for the onset and progression of endometriosis. Current data indicate that changes in the composition of gut microbiota and/or different stages of the female reproductive tract can be used prognostically as a tool for diagnosing the disease, whereas a number of microorganisms can be marker for assessing its form and prevalence. This review considers the present-day ideas on the relationship between the gut and genital microbiotas and endometriosis, on possible mechanisms and diagnostic approaches to this pathological condition.
Conclusion: To study the composition of the microbiota seems to be a fairly new and very promising area from both scientific and practical point of view.

Keywords

endometriosis
microorganisms
microbiome
microbiota
gut microbiota
genital microbiota
lipopolysaccharide
16S rRNA gene sequencing
Full text (in Russian)

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Received 11.04.2022

Accepted 10.06.2022

About the Authors

Galina E. Chernukha, Dr. Med. Sci., Professor, Chief Researcher, obstetrician-gynecologist at the Department of Gynecological Endocrinology, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian Federation, +7(985)999-60-00, c-galina1@yandex.ru,
117997, Russia, Moscow, Ac. Oparin str., 4.
Veronika A. Pronina, obstetrician-gynecologist, PhD student, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology,
Ministry of Health of Russian Federation, +7(916)025-86-26, ver22595@yandex.ru, https://orcid.org/0000-0003-4566-4065, 117997, Russia, Moscow, Ac. Oparin str., 4.
Tatiana V. Priputnevich, Dr. Med. Sci., Associate Professor, Director of the Institute of microbiology, antimicrobial therapy and epidemiology, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian Federation, +7(910)414-56-16, priput1@gmail.com,
117997, Russia, Moscow, Ac. Oparin str., 4.
Corresponding author: Galina E. Chernukha, c-galina1@yandex.ru

Authors' contributions: Pronina V.A., Chernukha G.E. – material collection and processing; writing the text; Chernukha G.E., Priputnevich T.V. – editing.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation has been conducted within the research “Elaboration of an integrated approach to diagnosing hormone-related diseases and endometrial functional disorders on the basis of a microbiota study” 122020900123-4.
For citation: Chernukha G.E., Pronina V.A., Priputnevich T.V.
Gut and genital microbiota in endometriosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 8: 22-29 (in Russian)
http://dx.doi.org/10.18565/aig.2022.8.22-29

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