Critical near-miss conditions in obstetrics: difficulties in diagnosis and therapy

Pyregov A.V., Shmakov R.G., Fеdorova Т.А., Yurova M.V., Rogachevsky О.V., Grishchuk К.А., Strelnikova E.V.

1) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia
Background. A near-miss (NM) woman is a pregnant or puerperal woman in the critical condition - near death during pregnancy, childbirth, or within 42 days after delivery and who has survived the specified period. The management of obstetric patients who are on the verge of life and death (near miss) always presents great difficulties and requires a multidisciplinary approach, the use of modern diagnostic and treatment methods, and the mobilization of significant material investments. Analysis of obstetric near misses is the subject of a systematic study, which can assess the quality and level of organization of the work at the health care facilities providing specialized obstetric/gynecological care.
Case report. The paper analyzes the management and treatment of a patient from the near-miss category with HELLP syndrome, sepsis, secondary thrombotic microangiopathy, and acute kidney injury, which are manifested after operative delivery.
Conclusion. The timely and rapid routing of a patient to a third-level obstetric health care facility, the use of modern high-tech diagnostic and treatment methods contributed to the preservation of life in the patient and her hospital discharge in satisfactory condition.

Keywords

pregnancy
near-miss
HELLP syndrome
sepsis
thrombotic microangiopathy
extracorporeal hemocorrection methods

References

  1. Аудит критических акушерских состояний в Российской Федерации в 2016 году. Методическое письмо МЗ РФ от 23 октября 2017 года N 15-4/10/2-7340). [Audit kriticheskikh akusherskikh sostoyaniy v Rossiyskoy Federatsii v 2016 godu. Metodicheskoye pis’mo MZ RF ot 23 oktyabrya 2017 goda N 15-4/10/2-7340). (In Russ.)].
  2. Abdou H.F.A., Abbas A.M., Omar A.M. Audit for quality of care and fate of maternal critical cases at Women’s Health Hospital. Applied Nursing Research. 2017; 39. doi:10.1016/j.apnr.2017.11.003
  3. Oliveira Neto A.F., Parpinelli M.A., Costa M.L., Souza R.T., Ribeiro do Valle C., Cecatti J.G. Exploring Epidemiological Aspects, Distribution of WHO Maternal Near Miss Criteria, and Organ Dysfunction Defined by SOFA in Cases of Severe Maternal Outcome Admitted to Obstetric ICU: A Cross-Sectional Study. Biomed Res Int. 2018; 2018: 5714890. doi:10.1155/2018/5714890
  4. Say L., Pattinson R.C., Gülmezoglu A.M. WHO systematic review of maternal morbidity and mortality: the prevalence of severe acute maternal morbidity (near miss). Reprod Health. 2015; 1(3): 3. doi: 10.1186/1742-4755-1-3
  5. Мамонтова И.К., Шевлякова Т.В., Петрова Е.И. “Near miss” в акушерстве: место в оценке технологий здравоохранения, подходы к классификации и оценке. Фармакоэкономика. Современная фармакоэкономика и фармакоэпидемиология. 2018; 11(4): 92–6. [Мamontova I.K., Shevlyakovа T.V., Petrova E.I. “Near miss” in obstetrics: classification, evaluation, and significance for healthcare technology assessment. Farmakoekonomika. Modern Pharmacoeconomic and Pharmacoepidemiology. 2018;11(4): 92–6. (In Russ.)]. https://doi.org/10.17749/2313-7347.2018.11.4.092-096
  6. Улучшение качества акушерской и перинатальной помощи. Внедрение цикла анализа критических случаев в акушерской практике на уровне стационара. Пособие и практические инструменты. Европейское региональное бюро ВОЗ. 2016; 104 с. [Электронный ресурс]URL: http://www.euro.who.int/_data/assets/pdf_file/0004/324391/NMCR-manual-ru.pdf. [Uluchsheniye kachestva akusherskoy i perinatal’noy pomoshchi. Vnedreniye tsikla analiza kriticheskikh sluchayev v akusherskoy praktike na urovne statsionara. Posobiye i prakticheskiye instrumenty. Yevropeyskoye regional’noye byuro VOZ. 2016; 104 s. [Elektronnyy resurs] URL: http://www.euro.who.int/_data/assets/pdf_file/0004/324391/NMCR-manual-ru.pdf.
  7. Приказ Минздрава России от 1 ноября 2012 г. № 572н «Об утверждении Порядка оказания медицинской помощи по профилю “акушерство и гинекология (за исключением использования вспомогательных репродуктивных технологий). [Order of the Ministry of Health of Russia of November 1, 2012 No. 572n “On approval of the Procedure for the provision of medical care in the profile” obstetrics and gynecology (except for the use of assisted reproductive technologies). (In Russ.)]
  8. Standards and Guidelines. Intensive Care Society.http://www.ics.ac.uk/intensive_care_professional/standards_and_guidelines/levels_of_adult_patients Accessed 09 March, 2014
  9. Аудит критических акушерских состояний в Российской Федерации в 2016 году. Методическое письмо МЗРФ от 23 октября 2017 года N 15-4/10/2-7340. [Audit kriticheskikh akusherskikh sostoyaniy v Rossiyskoy Federatsii v 2016 godu. Metodicheskoye pis’mo MZRF ot 23 oktyabrya 2017 goda N 15-4/10/2-7340. (In Russ.)]. http://docs.cntd.ru/document/556168785
  10. Oliveira Neto A.F., Parpinelli M.A., Costa M.L., Souza R.T., Ribeiro do Valle C., Cecatti J.G. Exploring Epidemiological Aspects, Distribution of WHO Maternal Near Miss Criteria, and Organ Dysfunction Defined by SOFA in Cases of Severe Maternal Outcome Admitted to Obstetric ICU: A Cross-Sectional Study. BioMed Res Int. 2018; 2018: 5714890. doi:10.1155/2018/5714890
  11. Souza I.P., Cecatti I.G., Faundes A. Maternal near miss and Maternal death in the World. Health Organisation’ s 2005 global survery on maternal and perinatal health. Bull World Healtu Organ. 2010; 88(23): 113–9. doi: 10.2471/BLT.08.057828.
  12. Souza I.P., Cecatti I.G., Haddad S.M. The WHO Maternal near miss approach ant the material severity index model (msi): tools for assessing the management of severe material morbidity. Plos One. 2012; 7(8): 137. doi: 10.1371/journal.pone.004412924
  13. Тутынина О.В., Егорова А. Т., Виноградов К.А. Тяжелые акушерские осложнения («near miss»): проблемы, поиски, решения. Медицинский вестник Северного Кавказа. 2016; 11 (4): 609–12. [Tutynina O.V., Egorova A.T., Vinogradov K.A. Severe obstetric complications («near miss»): problems, searches, solutions. Meditsinskii vestnik Severnogo Kavkaza. 2016;11(4):606-612. (In Russ.)]. doi: 10.14300/mnnc.2016.11149.
  14. Nates J. L., Nunnally M., Kleinpell R., Blosser S., Goldner J., Birriel B., et al ICU Admission, Discharge, and Triage Guidelines. Critical Care Medicine. 2016; 44(8): 1553–1602. doi:10.1097/ccm.0000000000001856
  15. Заболотских И.Б., Мусаева Т.С. Денисова Е.А. Валидность шкал APACHE II, APACHE III, SAPS 2, SAPS 3 и SOFA у акушерских больных с сепсисом. Анестезиология и реаниматология. 2012; 6: 55–7. [Zabolotskyh I.B., Musaeva T.S., Denisova E.A. Validity of APACHE II, APACHE III, SAPS 2, SAPS 3 and SOFA scales in obstetric patients with sepsis. Anesteziologiya i reanimatologiya. 2012; 6: 55–7. (In Russ.)].
  16. Singer M., Deutschman C.S., Seymour C.W., Shankar-Hari M., Annane D., Bauer M., et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315(8): 801–10. doi: 10.1001/jama.2016.0287.
  17. Fakhouri F., Vercel C., Frémeaux-Bacchi V. Obstetric nephrology: AKI and thrombotic microangiopathies in pregnancy. Clin J Am. Soc Nephrol. 2012; 7(12): 2100–6. doi: 10.2215/CJN.13121211.
  18. Gupta M., Feinberg, B.B., Burwick R.M. Thrombotic microangiopathies of pregnancy: Differential diagnosis. Pregnancy Hypertension. 2018; 12: 29–34. doi:10.1016/j.preghy.2018.02.007
  19. Pourrat O., Coudroy R., Pierre F. Differentiation between severe HELLP syndrome and thromboticmicroangiopathy, thrombotic thrombocytopenic purpura and other imitators. Eur J Obstet Gynecol Reprod Biol. 2015; 189: 68–72. doi: 10.1016/j.ejogrb.2015.03.017.
  20. Калачин К.А., Пырегов А.В., Федорова Т.А., Грищук К.И., Шмаков Р.Г. «Нетипичный» HELLP-синдром или атипичный гемолитико-уремический синдром? Акушерство и гинекология. 2017; 1: 5–11. [Kalachin K.A., Pyregov A.V., Fedorova T.A., Grishchuk K.I., Shmakov R.G. Atypical HELLP syndrome or atypical hemolytic uremic syndrome? Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (1): 94-102. (in Russ.)].http://dx.doi.org/10.18565/aig.2017.1.94-102.
  21. Пырегов А.В., Федорова Т.А., Королев А.Ю., Грищук К.И. Атипичный гемолитико-уремический синдром у пациентки с менометроррагией (клиническое наблюдение). Вестник анестезиологии и реаниматологии. 2016; 13(3): 63–70. [Pyregov A.V., Fedorova T.A., Korolev A.YU., Grischuk K.I.Atypical hemolytic-uremic syndrome in the female patient with concurrent menometrorrhagia (clinical case). Messenger of Anesthesiology and Resuscitation. 2016; 13(3): 63–70. (In Russ.)]. https://doi.org/10.21292/2078-5658-2016-13-3-63-70
  22. Козловская Н.Л., Прокопенко Е.И., Эмирова Х.М., Серикова С.Ю. Клинические рекомендации по диагностике и лечению атипичного гемолитико-уремического синдрома. Нефрология и диализ. 2015; 17(3): 242–64. [Kozlovskaya N.L., Prokopenko E.I., Emirova H.M., Serikova S.Yu. Clinical recommendations for the diagnosis and treatment of atypical hemolytic uremic syndrome. Nephrology and dialysis. 2015; 17 (3): 242–64. (In Russ.)].
  23. Краснопольский В.И., Шифман Е.М., Куликов А.В, Козловская Н.Л., Артымук Н.В., Белокриницкая Т.Е., Гурьева В.М., Упрямова Е.Ю., Смирнов Г.А., Степанюк В.А., Матковский А.А., Коротчаева Ю.В. Отчет о проведении Форума экспертов «Тромботические микроангиопатии и атипичный гемолитико-уремический синдром в акушерстве. Первый шаг к междисциплинарному консенсусу». Российский вестник акушера-гинеколога. 2017; 17(1): 118–25. [Krasnopolsky V.I., Shifman E.M., Kulikov A.V., Kozlovskaya N.L., Artymuk N.V., Belokrinitskaya T.E., Guryeva V.M., Upryamova E.Yu., Smirnov G.A., Stepanyuk V.A., Matkovsky A.A., Korotchaeva Yu.V. Report on Experts Forum «Thrombotic microangiopathies and atypical hemolytic-uremic syndrome in obstetrics. The first step to cross-disciplinary consensus». Russian Bulletin of Obstetrician-Gynecologist/Rossiyskiy vestnik akushera-ginekologa. 2017; 17(1): 118–25. (In Russ.)]. doi: 10.17116/rosakush2017171118-125
  24. Пырегов А.В., Калачин К.А. Акценты интенсивной терапии тяжелой преэклампсии/эклампсии и осложнений. Экстренная медицина. 2018; 7(2): 280–5. [Pyregov A.V., Kalachin K.A.Accents of intensive care of severe preeclampsia/eclampsia and complications. Ekstrennaya meditsina/Emergency medicine. 2018; 7(2): 280–5.(In Russ.)].
  25. Go R.S., Winters J.L., Leung N., Murray D.L., Willrich M.A., Abraham R.S., Botero, J.P. Thrombotic Microangiopathy Care Pathway: A Consensus Statement for the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease-Oriented Group. Mayo Clinic Proceedings. 2016; 91(9): 1189–1211. https://doi.org/10.1016/j.mayocp.2016.05.015
  26. Claes K., Massart A., Collard L., Weeker L., Goffin E., Pochet Jean-M., Dahan K., Morelle J., Adams Br., Broeders N., et al. Belgian consensus statement on the diagnosis and management of patients with atypical hemolytic uremic syndrome. Acta Clinica Belgica. 2018; 73(1): 80–9. doi: 10.1080/17843286.2017.1345185.
  27. Федорова Т.А., Стрельникова Е.В., Рогачевский О.В., Пырегов А.В., Пучко Т.К., Виноградова М.А., и др. Роль и место плазмообмена в терапии синдрома тромботической микроангиопатии в акушерстве. Акушерство и гинекология. 2018; 8: 5–11. [Fedorova T.A., Strelnikova E.V.,Rogachevsky O.V., Pyregov A.V., Puchko T.K., Vinogradova M.A., Kirsanova T.V. The role and place of plasma exchange in the therapy of thrombotic microangiopathy syndrome in obstetrics. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (8): 5-11. (in Russ.)]. https://dx.doi.org/10.18565/aig.2018.8.5-11
  28. Ярустовский М.Б., Рей С.И., Белых А.Н., Захаров М.В., Кулабухов В.В., Хорошилов С.Е., Яковлева И.И. Современные методы экстракорпоральной детоксикации в комплексном лечении сепсиса. В книге: Сепсис: классификация, клинико-диагностическая концепция и лечение. Под ред. акад. РАН Б.Р. Гельфанда. 4-е изд., доп. и перераб. М.: ООО «Медицинское информационное агентство», 2017. 408 с. [Yarustovskiy M.B.,Rey S.I., Belykh A.N., Zakharov M.V., Kulabukhov V.V.,Khoroshilov S.Ye., Yakovleva I.I. Sovremennyye metody ekstrakorporal’noy detoksikatsii v kompleksnom lechenii sepsisa. V knige: Sepsis: klassifikatsiya, kliniko-diagnosticheskaya kontseptsiya i lecheniye. Pod red. akad. RAN B.R. Gel’fanda. 4-ye izd., dop. i pererab. M.: OOO «Meditsinskoye informatsionnoye agentstvo», 2017. 408 s. (In Russ.)]. ISBN 978-5-8948-1797-2
  29. Knaup H., Stahl K., Schmidt B.M.W., Idowu T.O., et al. Early therapeutic plasma exchange in septic shock: a prospective open-label nonrandomized pilot study focusing on safety, hemodynamics, vascular barrier function, and biologic markers. Crit Care. 2018; 22(285): 357. https://doi.org/10.1186/s13054-018-2220-9
  30. David S., Hoeper M.M., Kielstein J.T. Plasma exchange in treatment refractory septic shock: presentation of a therapeutic add-on strategy. Med Klin Intensivmed Notfmed. 2017; 112: 42–6. doi: 10.1007/s00063-015-0117-9.
  31. David S., Thamm K., Falk C.S., Kielstein J.T. Effect of extracorporeal cytokine removal on vascular barrier function in a septic shock patient. J. Intensive Care. 2017; 21(5):12–6. doi: 10.1186/s40560-017-0208-1.
  32. Berlot G., Agbedjro A., Tomasini A., et al. Effects of the volume of processed plasma on the outcome, arterial pressure and blood procalcitonin levels in patients with severe sepsis and septic shock treated with coupled plasma filtration and adsorption . Blood Purif. 2014; 37(2): 146–51. doi: 10.1159/000360268.
  33. Протокол «Организация медицинской эвакуации беременных женщин, рожениц и родильниц при неотложных состояниях». Минздрав РФ, 2015 г. [Protocol “Organization of medical evacuation of pregnant women, women in childbirth and puerperas in emergency conditions”. Ministry of Health of the Russian Federation, 2015. (in Russ.)]. https://www.garant.ru/products/ipo/prime/doc/71137474/
  34. Uriol R.M.G., Cabello P.S., Ballester R.C., et al. Impact of a multidisciplinary team for the management of thrombotic microangiopathy. PLoS One. 2018; 13(11): e0206558. doi:10.1371/journal.pone.0206558
  35. Башмакова Н.В., Давыденко Н.Б., Мальгина Г.Б. Мониторинг акушерских «near miss» в стратегии развития службы родовспоможения. Российский вестник акушера-гинеколога. 2019; 19(3): 5-10. [Bashmakova NV, Davydenko NB, Malgina GB. Maternal near-miss monitoring as part of a strategy for the improvement of obstetric care. Russian Bulletin of Obstetrician-Gynecologist. 2019; 19(3): 5–10. (In Russ.)]. https://doi.org/10.17116/rosakush2019190315
  36. Dias A, Panda S., Singh S. Maternal near miss: a bigger challenge. Obstet Gynecol Int J. 2016; 4: 2 https://doi.org/10.15406/ogij.2016.04.00099
  37. Farr A., Lenz-Gebhart A., Einig S., Ortner C., Holzer I., Elhenicky M., Husslein P.W., Lehner R. Outcomes and trends of peripartum maternal admission to the intensive care unit. Wien Klin Wochenschr. 2017; 129: 605–11. doi:10.1007/s00508-016-1161-z

Received 25.10.2019

Accepted 29.11.2019

About the Authors

Aleksey V. Pyregov, MD, associate professor, head of the Department of Anesthesiology and Resuscitation of FSBI NMRC for OG&P named after Acad. V.I. Kulakov
Ministry of Health of Russia. Phone:+74954387777. E-mail: a_pyregov@oparina4.ru
Adress:117997, Russia, Moscow, Ac. Oparin str. 4.
Roman G. Shmakov, MD, professor, Director of the Institute of obstetrics of FSBI NMRC for OG&P named after Acad. V.I. Kulakov Ministry of Health of Russia. Phone:+74954382489. E-mail: r_shmakov@oparina4.ru
Adress:117997, Russia, Moscow, Ac. Oparin str. 4.
Tatiana A. Fedorova, MD. professor, Chief of transfusional department of FSBI NMRC for OG&P named after Acad. V.I. Kulakov Ministry of Health of Russia.
Phone: +7(495) 438-71-35 E-mail: t_fyodorova@oparina4.ru https://orcid.org/0000-0001-6714-6344
Adress:117485, Russia , Moscow , acad. Oparin st. 4.
Maria V. Yurova, Postgraduate Student of the Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), resident of FSBI NMRC for OG&P named after Acad. V.I. Kulakov Ministry of Health of Russia.
E-mail: m_yurova@oparina4.ru; https://orcid.org/0000-0002-0179-7635. Address:117485, Russia, Moscow, Acad. Oparin, 4.
Oleg V. Rogachevskiy, MD, professor, head of the Department of extracorporeal methods of treatment and detoxification, Professor Department of Anesthesiology and Resuscitation of FSBI NMRC for OG&P named after Acad. V.I. Kulakov Ministry of Health of Russia. Phone: +7(495)438-71-35.
E-mail: о_rogachevskiy@oparina4.ru4. https://orcid.org/0000-0002-4332-430X
Address:117485, Russia, Moscow, Acad. Oparin, 4.
Konstantin I. Grischuk, physician of the Department of Anesthesiology and Resuscitation of FSBI NMRC for OG&P named after Acad. V.I. Kulakov Ministry of Health of Russia. Phone: +7(495) 438-77-77. E-mail: k_grishuk@oparina4.ru
Address: 117485, Russia, Moscow, st. Acad. Oparina , 4.
Elena V. Strelnikova, MD, doctor of transfusional department of FSBI NMRC for OG&P named after Acad. V.I. Kulakov Ministry of Health of Russia.
Теl.: +7(495) 438-71-35. E-mail: е_strelnikova@oparina4.ru
Address: 117997, Russia, Moscow, acad. Oparin st. 4.

For citation: Pyregov A.V., Shmakov R.G., Fеdorova Т.А. Yurova M.V., Rogachevsky О.V., Grishchuk К.А., Strelnikova E.V. Critical near-miss conditions in obstetrics: difficulties in diagnosis and therapy.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 3: 228-37. (In Russian).
https://dx.doi.org/10.18565/aig.2020.3.228-237

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.