Functional disorders of the liver in the first trimester of pregnancy

Kryshnia M.A., Mozgovaya E.V.

1) Multidisciplinary Medical Holding “SM-Clinic”, St. Petersburg, Russia; 2) D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russia; 3) St. Petersburg State University, St. Petersburg, Russia
Any abnormal liver function can simultaneously present with the onset of pregnancy. This may be a pre-existing chronic liver disease or liver dysfunction associated with pregnancy. Consultation for liver disease in pregnancy is a challenge for both the hepatologist and gynecologist, since the normal physiological changes during pregnancy can mimic chronic liver disease. Pregnancy-specific liver diseases are the main causes of abnormal tests of the hepatic panel. In this case, as much as 3% of all pregnant women in developed countries suffer from liver diseases to unrelated pregnancy. The main factors determining the prognosis of the course of pregnancy for the mother are the type of liver disease and the degree of synthetic, metabolic, and excretory liver dysfunctions. This paper deals with a systematic approach to diagnosing and treating pregnancy-specific liver diseases in the first trimester, which includes an understanding of normal outcomes during pregnancy, exclusion of liver diseases nonspecific to pregnancy, consideration of the early onset of blood biochemical changes, and use of clinical data for early diagnosis and timely treatment.
Conclusion: The studied data on the etiology and pathogenesis, diagnosis and principles of treatment of functional disorders of the liver in the first trimester of pregnancy can serve as a reason for further in-depth studies of hepatopathy in order to expand the understanding of the prevalence and etiopathogenesis, prediction and drug correction of this pathology for the prevention of maternal and perinatal morbidity.


liver diseases
hyperemesis gravidarum
drug-induced hepatopathies
non-alcoholic fatty liver disease


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Received 24.05.2022

Accepted 13.09.2022

About the Authors

Marina A. Kryshnia, obstetrician-gynecologist, multidisciplinary medical holding «SM-Clinic», +7(963)317-10-70,,
192288, Russia, St. Petersburg, Dunaiskiy Ave, 47.
Elena V. Mozgovaya, Dr. Med. Sci., Head of the Department of Obstetrics and Perinatology, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 199034, Mendeleevskaya linia, 3, St. Petersburg, Russia; Professor at the Department of Obstetrics, Gynecology and Reproductology, Medical Faculty, St. Petersburg State University, Russia, St. Petersburg, V.O., 21 Line, 8а, +7(911)929-99-47, elmozg@, WOS Research ID L-1432-2017,
Scopus Author ID 24822403200,, SPIN 5622-5674.

Authors’ contributions: Mozgovaya E.V., Kryshnia M.A. – concept and design of the investigation; material collection and processing, writing the text; Mozgovaya E.V. – editing.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has been performed at the D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology within the framework of state funding on Federal Tax Office topic No. FGWN-2022-0004.
For citation: Kryshnia M.A., Mozgovaya E.V.
Functional disorders of the liver in the first trimester of pregnancy.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 11: 14-22 (in Russian)

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