Epigenetic aspects of the pathogenesis of preeclampsia

Kan N.E., Mirzabekova D.D., Tyutyunnik V.L., Krasnyi A.M.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Preeclampsia is a serious pregnancy complication that is a leading cause of maternal and perinatal morbidity and mortality. Of great interest is the study of new approaches to preventing, predicting, and treating this syndrome; however, it is difficult without understanding the basics of pathogenesis. The paper considers modern ideas about the mechanisms of preeclampsia. Fundamental significance is attached to the activation of the immune system; the cells of both innate and adaptive immunity are assumed to play a key role. It is known that epigenetic mechanisms, such as DNA methylation and the action of non-coding RNAs (ncRNAs), regulate many genes, including those involved in inflammation and immune response, and can serve as prognostic biomarkers and therapeutic targets in preeclampsia.
Conclusion: The study of etiopathogenesis can become the basis for revealing the mechanism of this pregnancy complication, which directly facilitates the search for new markers for the early diagnosis of preeclampsia.


innate immunity
monocyte-macrophage response
epigenetic mechanisms


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Received 23.08.2022

Accepted 14.09.2022

About the Authors

Natalia E. Kan, Professor, MD, PhD; Deputy Director of Science; Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(926)220-86-55, kan-med@mail.ru, Researcher ID: B-2370-2015, SPIN-код: 5378-8437, Authors ID: 624900,
Scopus Author ID: 57008835600, https://orcid.org/0000-0001-5087-5946, 117997, Russia, Moscow, Ac. Oparina str., 4.
Dzhamilia D. Mirzabekova, graduate student, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health
of Russia, +7(906)110-51-13, +7(920)984-94-07, Jamilya1705@yandex.ru, https://orcid.org/0000-0002-2391-3334, 117997, Russia, Moscow, Ac. Oparina str., 4.
Victor L. Tyutyunnik, Professor, MD, PhD, Leading Researcher of Research and Development Service, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(903)969-50-41, tioutiounnik@mail.ru, Researcher ID: B-2364-2015,
SPIN-код: 1963-1359, Authors ID: 213217, Scopus Author ID: 56190621500, https://orcid.org/0000-0002-5830-5099, 117997, Russia, Moscow, Ac. Oparina str., 4.
Aleksey M. Krasnyi, PhD, Head of the Cytology Laboratory, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia, +7(495)438-22-72, alexred@list.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.

Authors’ contributions: Kan N.E., Mirzabekova D.D., Tyutyunnik V.L., Krasnyi A.M. – concept and development of the design of the investigation, obtaining the data to be analyzed, collection of publications, processing and analyzing the material on the topic, writing the text of the manuscript, editing the article.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has not been sponsored.
For citation: Kan N.E., Mirzabekova D.D., Tyutyunnik V.L., Krasnyi A.M.
Epigenetic aspects of the pathogenesis of preeclampsia.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 12: 5-10 (in Russian)

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