Endometriosis, adenomyosis, chronic endometritis: clinical and pathogenetic relationships and reproductive failure
The article highlights the clinical and pathogenetic relationships between endometriosis/adenomyosis and chronic endometritis (CE) within reproductive failures. It describes a cause-and-effect relationship between endometriosis/adenomyosis and CE by the example of its clinical symptomatology and the pathogenic mechanisms involving an autoimmune process, aseptic inflammation, and altered endometrial receptivity. Endometriosis/adenomyosis and CE have a number of common pathogenetic mechanisms of development and clinical manifestations (infertility, recurrent miscarriages, and assisted reproductive program failures). This implies the necessity to qualitatively assess the endometrium in women with endometriosis and adenomyosis during pregravid preparation, as well as the search for new therapeutic ways to correct autoimmune disorders. The use of sodium desoxyribonucleate (derinat) showing the pharmacological properties of an activator of the cellular and humoral immune system and a stimulator of reparative and regenerative processes is a promising approach to drug therapy.Unanyan A.L., Sidorova I.S., Kogan E.A., Belogubova S.Yu., Demura T.A., Elisavetskaya A.M., Sizova N.M.
Keywords
chronic endometritis
endometriosis
adenomyosis
infertility
miscarriage
reproductive disorders
sodium desoxyribonucleate
derinat
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Received 10.08.2018
Accepted 21.09.2018
About the Authors
Unanyan, Ara L., MD, Professor of the Department of Obstetrics and Gynecology № 1 of the Faculty of Medicine, Head of the Clinical Base of the Department of Obstetrics and Gynecology № 1 of the Faculty of Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, (Sechenov University).119991, Russia, Moscow, Trubetskaya str. 8/2. Tel.: +79039603526. E-mail: 9603526@mail.ru
Sidorova, Iraida S., Academician of RAS, Honored Scientist of the Russian Federation, Honored Doctor of the Russian Federation, Professor, MD, Professor of the Department of Obstetrics and Gynecology № 1 of the Faculty of Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia,
(Sechenov University). 119991, Russia, Moscow, Trubetskaya str. 8/2. E-mail: sidorovais@yandex.ru
Kogan, Evgenia A., MD, professor, full member of the Russian division of the International Academy of Pathology, Head of the Department, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, (Sechenov University). 119991, Russia, Moscow, Trubetskaya str. 8/2
Belogubova, Sofiya Yu., a 6th year student of the International School “Medicine of the Future” of the Faculty of Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, (Sechenov University). 119991, Russia, Moscow, Trubetskaya str. 8/2. Tel.: +79266004619. E-mail: belogubovasofia@gmail.com
Demura, Tatyana A., MD, professor of the Department of Pathology, I.M. Sechenov First Moscow State Medical University,
Ministry of Health of Russia, (Sechenov University). 119991, Russia, Moscow, Trubetskaya str. 8/2
Elisavetskaya, Aleksandra M., head of the Women’s consultation office № 7, Women’s Consultation Clinic Seven, Branch, Maternity Hospital Twenty-Five, N.I. Pirogov
City Clinical Hospital One, Moscow Healthcare Department. 117049, Russia, Moscow, Leninsky Prospect, 8. E-mail: gkb1@zdrav.mos.ru
Sizova, Natalia M., obstetrics and gynecology resident doctor, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named
after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: sizova-natasha@yandex.ru
For citations: Unanyan A.L., Sidorova I.S., Kogan E.A., Belogubova S.Yu., Demura T.A., Elisavetskaya A.M., Sizova N.M. Endometriosis, adenomyosis, chronic endometritis: clinical and pathogenetic relationships and reproductive failures. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (10): 136-40. (in Russian)
https://dx.doi.org/10.18565/aig.2018.10.136-140
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