The effectiveness of non-invasive prenatal testing in multiple pregnancy: a systematic review and a meta-analysis

Bespalova O.N., Butenko M.G., Pachulia O.V., Glotov A.S., Kogan I.Yu.

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, Saint Petersburg, Russia
Objective. To study the effectiveness of non-invasive prenatal testing (NIPT) for trisomy 21, 18, and 13 in twin pregnancy, by using a meta-analysis.
Materials and methods. The meta-analysis was carried out in accordance with the user’s guide for writing a meta-analysis, which had been recommended by the Cochrane community 2016. The investigators analyzed the literature found in the largest databases: MEDLINE via PubMed, EMBASE, CENTRAL (Cochrane Library), ClinicalTrials.gov, and the World Health Organization International Clinical Trials Registry Platform (ICTRP). The indicators were estimated by the meta-analysis using Review Manager 5.4.1 (Cochrane col., UK).
Results. A total of 19 trials were selected and analyzed. A total of 7138 pregnant women were included in the meta-analysis. The latter revealed that the sensitivity and specificity of NIPT for trisomy 21, 18, and
13 in the fetus were 0.98 (95% CI 0.75–1.00), 0.99 (95% CI 0.99–1.00), and 0.97 (95% CI 0.5–1.00), and
0.99 (95% CI 0.99–1.00), 0.875 (95% CI 0–1.00), and 0.99 (95% CI 0.99–1.00), respectively.
Conclusion. NIPT demonstrates the high efficiency of detecting trisomy 21 and 18, which is comparable to singlet pregnancy. The authors could not significantly evaluate the effectiveness of NIPT for trisomy 13, due to the insufficient number of trials, in which the pregnancies at increased risk for trisomy 13 were identified.

Keywords

non-invasive prenatal test
non-invasive prenatal diagnosis
fetal DNA
fetal fraction
twin pregnancy

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Received 04.05.2021

Accepted 21.06.2021

About the Authors

Olesya N. Bespalova, PhD, Deputy Director, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology.
Tel.: +7(812)328-98-68. E-mail: bespalova.olesya.0308@gmail.com. ORCID: 0000-0002-6542-5953. 199034, Russia, St. Petersburg, Mendeleyevskaya Liniya, 3.
Maria G. Butenko, resident, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology. Tel.: +7(981)963-67-17. E-mail: butenkomariabutenko@gmail.com.
ORCID: 0000-0002-1404-371X. 199034, Russia, St. Petersburg, Mendeleyevskaya Liniya, 3.
Olga V. Pachuliya, obstetrician-gynecologist, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology. Tel.: +7(952)268-73-36.
E-mail: for.olga.kosyakova@gmail.com. ORCID: 0000-0003-4116-0222. 199034, Russia, St. Petersburg, Mendeleyevskaya Liniya, 3.
Andrey S. Glotov, PhD, Senior Researcher, Head of Department of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology.
Tel.: +7(812)679-55-51. E-mail: anglotov@mail.ru. ORCID: 0000-0002-7465-4504. 199034, Russia, St. Petersburg, Mendeleyevskaya Liniya, 3.
Igor Yu. Kogan, Corresponding Member of RAS, Dr. Med. Sci., Professor, Director of D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology.
Tel.: +7(812)32-98-22. E-mail: ovrt@ott.ru. ORCID: 0000-0002-7351-6900. 199034, Russia, St. Petersburg, Mendeleyevskaya Liniya, 3.

For citation: Bespalova O.N., Butenko M.G., Pachulia O.V., Glotov A.S., Kogan I.Yu. The effectiveness of non-invasive prenatal testing in multiple pregnancy: a systematic review and a meta-analysis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 7: 10-18 (in Russian)
https://dx.doi.org/10.18565/aig.2021.7.10-18

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