Androgen receptors and their uniqueness
Androgens and their receptors play an important role in female reproductive function. The potential role of androgens in the female body is determined by the presence of a significant pool of androgen receptors in the tissues of the reproductive system, including the endometrium, ovaries, fallopian tubes, and myometrium. The most impressive advances in the study of androgen receptors have recently been achieved due to an increasing growing attention to androgens, their role in human physiology in both men and women, the expediency of combined hormone therapy with androgens for various conditions accompanied by their deficiency, including for infertility and reproductive failures, in patients with a poor response and a low ovarian reserve and in the postmenopausal period.Tskhovrebova L.T., Shevtsova M.A., Aksenenko A.A., Durinyan E.R., Gavisova A.A.
Conclusion. Thanks to modern biotechnology, the mechanisms underlying the activation of androgen receptors are becoming known, and their potential properties given in this paper are revealed. Discovering the details of the mechanism of action of androgen receptors and their effectors will help search for new methods of diagnosis, prediction, and introduction of personalized treatment regimens.
Keywords
androgen receptors
androgens
testosterone
dihydrotestosterone
dehydroepiandrosterone
dehydroepiandrosterone sulfate
infertility
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Received 01.06.2020
Accepted 18.10.2020
About the Authors
Linda T. Tskhovrebova, clinical resident of the 2nd year of study, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. E-mail: linda.tskhovrebova@mail.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.Marina A. Shevtsova, clinical resident of the 2nd year of study, Academician V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. E-mail: marina_981995@mail.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.
Artem A. Aksenenko, Researcher of the 1st Gynecology Department, Academician V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. E-mail: a_axenenko@oparina4.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.
Evelina R. Durinyan, Ph.D., Researcher of the 1st Gynecology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. E-mail: e_durinyan@oparina4.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.
Alla A. Gavisova, Ph.D., Senior Researcher of the 1st Gynecology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. E-mail: gavialla@yandex.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.
For citation: Tskhovrebova L.T., Shevtsova M.A., Aksenenko A.A., Durinyan E.R., Gavisova A.A. Androgen receptors and their uniqueness.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 12: 62-66 (in Russian)
https://dx.doi.org/10.18565/aig.2020.12.62-66
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