Resolution of National Expert Council on prevention and treatment of iron deficiency anemia in pregnant women in the light of FIGO good practice recommendations on anemia in pregnancy (2025). Changing the paradigm of dosing. Priority of safety and tolerability. Treatment of iron deficiency anemia according to the "minimum effective dose" model
Changing the paradigm of dosing. Priority of safety and tolerability.
Treatment of iron deficiency anemia based on the "minimum effective dose" model
For citation: Resolution of National Expert Council on prevention and treatment of iron deficiency anemia in pregnant women in the light of FIGO good practice recommendations on anemia in pregnancy (2025). Changing the paradigm of dosing. Priority of safety and tolerability.
Treatment of iron deficiency anemia according to the "minimum effective dose" model.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (5): 197-204 (in Russian)
https://dx.doi.org/10.18565/aig.2026.152
References
- FIGO Working Group on Good Clinical Practice in Maternal-Fetal Medicine. Good clinical practice advice: Iron deficiency anemia in pregnancy. Int. J. Gynaecol. Obstet. 2019; 144(3): 322-4. https://dx.doi.org/10.1002/ijgo.12740
- Ubom A.E., Begum F., Ramasauskaite D., Nieto-Calvache A.J., Oguttu M., Nunes I. et al. FIGO good practice recommendations on anemia in pregnancy, to reduce the incidence and impact of postpartum hemorrhage (PPH). Int. J. Gynaecol. Obstet. 2025; 171(3): 993-1007. https://dx.doi.org/10.1002/ijgo.70529
- Duca L., Di Pierro E., Scaramellini N., Granata F., Graziadei G. The relationship between non-transferrin-bound iron (NTBI), labile plasma iron (LPI), and iron toxicity. Int. J. Mol. Sci. 2025; 26(13): 6433. https://dx.doi.org/10.3390/ijms26136433
- Министерство здравоохранения Российской Федерации. Клинические рекомендации. Железодефицитная анемия. 2024. [Ministry of Health of the Russian Federation. Clinical guidelines. Iron deficiency anemia. 2024 (in Russian)].
- Драпкина О.М., Авалуева Е.Б., Бакулин И.Г., Бакиров Б.А., Баранов И.И., Виноградова Н.Г., Виноградова М.А., Гапонова Т.В., Гаус О.В., Гиляревский С.Р., Голшмид М.В., Дроздова Л.Ю., Дудина Г.А., Жарова М.Е., Жибурт Е.Б., Журина О.Н., Иванова Е.В., Котовская Ю.В., Кохно А.В., Куликов И.А., Купряшов А.А., Ливзан М.А., Луговская С.А., Лукина Е.А., Наумов А.В., Павлюченко Е.С., Паровичникова Е.Н., Пономарев Р.В., Рунихина Н.К., Скаржинская Н.С., Стародубова А.В., Тарасова И.С., Тихомирова Е.В., Теплых Б.А., Ткачева О.Н., Троицкая В.В., Федоров Е.Д., Федорова Т.А., Ховасова Н.О., Чернов В.М., Чесникова А.И., Шепель Р.Н., Ших Е.В. Ведение пациентов с железодефицитной анемией на этапе оказания первичной медико-санитарной помощи. Методические рекомендации. Первичная медико-санитарная помощь. 2025; 2(3): 55-114. [Drapkina O.M., Avalueva E.B., Bakulin I.G., Bakirov B.А., Baranov I.I., Vinogradova N.G., Vinogradova M.A., Gaponova T.V., Gaus O.V., Gilyarevsky S.R., Golshmid M.V., Drozdova L.Y., Dudina G.A., Zharova M.E., Zhiburt E.B., Zhurina O.N., Ivanova E.V., Kotovskaya Y.V., Kohno A.V., Kulikov I.A., Kupryashov A.A., Livzan M.A., Lugovskaya S.A., Lukina E.A., Naumov A.V., Pavlyuchenko E.S., Parovichnikova E.N., Ponomarev R.V., Runikhina N.K., Skarzhinskaya N.S., Starodubova A.V., Tarasova I.S., Tikhomirova E.V., Teplykh B.A., Tkacheva O.N., Troitskaya V.V., Fedorov E.D., Fedorova T.A., Khovasova N.O., Chernov V.M., Chesnikova A.I., Shepel R.N., Shikh E.V. Management of patients with iron deficiency anemia in the context of primary health care. Guidelines. Primary Health Care (Russian Federation). 2025; 2(3): 55-114 (in Russian)]. https://dx.doi.org/10.15829/3034-4123-2025-61
- Pavord S., Daru J., Prasannan N., Robinson S., Stanworth S., Girling J. UK guidelines on the management of iron deficiency in pregnancy. Br. J. Haematol. 2020; 188(6): 819-30. https://dx.doi.org/10.1111/bjh.16221
- Turck D., Bohn T., Castenmiller J., de Henauw S., Hirsch-Ernst K.I., Knutsen H.K. et al. Scientific opinion on the tolerable upper intake level for iron. EFSA J. 2024; 22(6): e8819. https://dx.doi.org/10.2903/j.efsa.2024.8819
- Martínez Francés A., Martínez-Bujanda J.L. Efficacy and tolerability of oral iron protein succinylate: a systematic review of three decades of research. Curr. Med. Res. Opin. 2020; 36(4): 613-23. https://dx.doi.org/10.1080/03007995.2020.1716702
- Martinez-Frances A. Efficacy and tolerability of oral iron protein succinylate in the treatment of iron deficiency anemia in adults with diverse pathologies. Am. J. Int. Med. 2021; 9(4): 171-85. https://dx.doi.org/10.11648/j.ajim.20210904.13
- Urso K., Leal Martínez-Bujanda J., Del Prado J.M. Iron protein succinylate in the management of iron deficiency anemia: a comparative study with ferrous sulphate at low and high herapeutic doses. Nutrients. 2021; 13(3): 968. https://dx.doi.org/10.3390/nu13030968
- Huo C., Li G., Hu Y., Sun H. The impacts of iron overload and ferroptosis on intestinal mucosal homeostasis and inflammation. Int. J. Mol. Sci. 2022; 23(22): 14195. https://dx.doi.org/10.3390/ijms232214195
- Onorati M., Nicola M., Renda A., Lancia M., Di Nuovo F. Iron overload in gastric mucosa: underdiagnosed condition rarely documented in clinical and pathology reports. Cureus. 2020; 12(5): e8234. https://dx.doi.org/10.7759/cureus.8234
- Lichtenstern C.R., Akhtar N. The irony of iron pill gastritis: a case of delayed recognition and persistent injury in an elderly patient. Cureus. 2024; 16(10): e71565. https://dx.doi.org/10.7759/cureus.71565
- Bloor S.R., Schutte R., Hobson A.R. Oral iron supplementation—gastrointestinal side effects and the impact on the gut microbiota. Microbiol. Res. 2021; 12(2): 491-502. https://dx.doi.org/10.3390/microbiolres12020033
- Yousefi M.H., Masoudi A., Saberi Rounkian M., Mansouri M., Hojat B., Kaveh Samani M. et al. An overview of the current evidences on the role of iron in colorectal cancer: a review. Front. Oncol. 2025; 15: 1499094. https://dx.doi.org/10.3389/fonc.2025.1499094
- Sohal A., Kowdley K.V. A review of new concepts in iron overload. Gastroenterol. Hepatol. (N Y). 2024; 20(2): 98-107.
- Zhang Y., Lu Y., Jin L. Iron metabolism and ferroptosis in physiological and pathological pregnancy. Int. J. Mol. Sci. 2022; 23(16): 9395. https://dx.doi.org/10.3390/ijms23169395
- Ng S.W., Norwitz S.G., Norwitz E.R. The impact of iron overload and ferroptosis on reproductive disorders in humans: implications for preeclampsia. Int. J. Mol. Sci. 2019; 20(13): 3283. https://dx.doi.org/10.3390/ijms20133283
- Dentand A.L., Schubert M.G., Krayenbuehl P.A. Current iron therapy in the light of regulation, intestinal microbiome, and toxicity: are we prescribing too much iron? Crit. Rev. Clin. Lab. Sci. 2024; 61(7): 546-58. https://dx.doi.org/10.1080/10408363.2024.2331477
- Cancelo-Hidalgo M.J., Castelo-Branco C., Palacios S., Haya-Palazuelos J., Ciria-Recasens M., Manasanch J. et al. Tolerability of different oral iron supplements: a systematic review. Curr. Med. Res. Opin. 2013; 29(4): 291-303. https://dx.doi.org/10.1185/03007995.2012.761599
- Карахалис Л.Ю., Андреева М.Д., Ахиджак А.Н. Влияние воспаления на уровень железа у беременных. Фармакология & Фармакотерапия. 2023; (1): 26-32. [Karakhalis L.Yu., Andreeva M.D., Akhidzhak A.N. Influence of inflammation on iron levels in pregnant women. Pharmacology & Pharmacotherapy. 2023; (1): 26-32 (in Russian)]. https://dx.doi.org/10.46393/27132129_2023_1_26
- Хабаров С.В. Коррекция железодефицитного состояния у женщин в период беременности. Акушерство и гинекология. 2023; 6: 115-22. [Khabarov S.V. Correction of iron deficiency in women during pregnancy. Obstetrics and Gynecology. 2023; (6): 115-22 (in Russian)]. https://dx.doi.org/10.18565/aig.2023.146
- Михайлова О.И., Мирзабекова Д.Д., Тютюнник В.Л., Кан Н.Е. Терапия железодефицитной анемии в послеродовом периоде. Фармакология & Фармакотерапия. 2022; (3): 60-3. [Mikhailova O.I., Mirzabekova D.D., Tyutyunnik V.L., Kan N.E. Treatment of iron deficiency anemia in the postpartum period. Pharmacology & Pharmacotherapy. 2022; (3): 60-3 (in Russian)]. https://dx.doi.org/10.46393/27132129_2022_3_60
- Izquierdo L. Efficacy and tolerability of oral iron protein succinylate in the treatment of iron deficiency anemia in adults with gastrointestinal diseases. Int. J. Gastroenterol. 2021; 5(2): 40-7. https://dx.doi.org/10.11648/j.ijg.20210502.11



